运动对自噬的影响
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摘要
自噬在运动过程中最为关键的是维持细胞内稳态,运动作为自噬诱导剂的一种,可以通过调节Beclin-1、mTOR和p62等调控途径对自噬产生一定的影响。通过综述运动对自噬的调控作用,并探讨运动对自噬的分子机制及生理学意义,同时展望运动与自噬的研究前景,以期为科研人员研究运动对自噬的影响提供参考。
The most key function of autophagy during the exercise process is to maintain cells' inner steady,sports as one of autophagy inducers can produce influence through adjusting Beclin-1, mTOR and p62 and so on.By using the method of document, this paper summarizes adjustment function of sports on autophagy, discusses molecular mechanism and physiology signification of sports on autophagy, meanwhile, forecasts the research prospect of sports and autophagy, in order to provide reference for researchers to study influence of sports on autophagy.
The most key function of autophagy during the exercise process is to maintain cells' inner steady,sports as one of autophagy inducers can produce influence through adjusting Beclin-1, mTOR and p62 and so on.By using the method of document, this paper summarizes adjustment function of sports on autophagy, discusses molecular mechanism and physiology signification of sports on autophagy, meanwhile, forecasts the research prospect of sports and autophagy, in order to provide reference for researchers to study influence of sports on autophagy.
引文
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[27]Dethlefsen Maja M.,Kristensen Caroline M.,T?ndering Anna S.,et al.Impact of liver pgc-1αon exercise and exercise training-induced regulation of hepatic autophagy and mitophagy in mice on hff[J].Physiological Reports,2018,6(13):e13731.
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[29]Youngjeon Lee,Joo-Heon Kim,Hong Yunkyung,et al.Prophylactic effects of swimming exercise on autophagy-induced muscle atrophy in diabetic rats[J].Laboratory Animal Research,2012,28(3):171-179.
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[31]Jamart C,Francaux M,Millet G.Y.,et al.Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running[J].Journal of Applied Physiology,2012,112(9):1529-1537.
[32]Kang R.,Zeh H J,Lotze M T,et al.The beclin-1 network regulates autophagy and apoptosis[J].Cell Death&Differentiation,2011,18(4):571.
[33]Jamart C,Naslain D,Gilson H,et al.Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state[J].Am J Physiol Endocrinol Metab,2013,305(8):E964-E974.
[34]王倩,张珊,牛燕媚,等.高强度间歇运动与中等强度持续运动对小鼠代谢表型及骨骼肌自噬影响的对比研究[J].中国运动医学杂志,2018(2):138-142.
[35]Kou X.,Li J.,Liu X.,et al.Swimming attenuates d-galactose-induced brain aging via suppressing mir-34amediated autophagy impairment and abnormal mitochondrial dynamics[J].Journal of Applied Physiology,2017,122(6):18.
[36]Alex Sheril,Boss Andreas,Heerschap Arend,et al.Exercise training improves liver steatosis in mice[J].Nutrition&Metabolism,2015,12(1):29.
[37]Rosa-Caldwell M.E.,Lee D.E.,Brown J.L.,et al.Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice[J].Appl Physiol Nutr Metab,2017,42(2):148-156.
[2]Singh Rajat,Cuervo Ana Maria.Autophagy in the cellular energetic balance[J].Cell Metabolism,2011,13(5):495-504.
[3]Dong Y.,Undyala V.V.,Gottlieb R.A.,et al.Autophagy:Definition,molecular machinery,and potential role in myocardial ischemia-reperfusion injury[J].J Cardiovasc Pharmacol Ther,2010,15(3):220-230.
[4]Levine Douglas R.Green,Beth.To be or not to be How selective autophagy and cell death govern cell fate[J].Cell,2014,157(1):65-75.
[5]Rahman M,Mofarrahi M,Kristof A.S.,et al.Reactive oxygen species regulation of autophagy in skeletal muscles[J].Antioxid Redox Signal,2014,20(3):443-459.
[6]Medina Diego L.,Paola Simone Di,Peluso Ivana,et al.Lysosomal calcium signalling regulates autophagy through calcineurin and tfeb[J].Nature Cell Biology,2015,17(3):288-299.
[7]Currently.Autophagy is a promoter for aerobic exercise performance during high altitude training[J].Oxidative Medicine&Cellular Longevity,2018(2018):1-11.
[8]Chen Ching Yi,Hsiu-Ching Hsu,Bai-Chin Lee,et al.Exercise training improves cardiac function in infarcted rabbits:Involvement of autophagic function and fatty acid utilization[J].European Journal of Heart Failure,2014,12(4):323-330.
[9]Pierre N,Appriou Z,Arlette G.D.,et al.From physical inactivity to immobilization:Dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy[J].Free Radical Biology&Medicine,2016,98:197-207.
[10]陈佳意,习阳,步世忠.自噬在非酒精性脂肪肝合并糖尿病中的作用[J].生命科学,2017,(11):1156-1160.
[11]张璐璐,张月英,张维东.自噬与肿瘤干细胞的研究进展[J].国际肿瘤学杂志,2014,41(4):248-251.
[12]钱帅伟,漆正堂,支彩霞,等.抑癌基因p53与细胞自噬[J].生命的化学,2011,31(5):640-646.
[13]钱帅伟,罗艳蕊,漆正堂,等.细胞自噬的分子学机制及运动训练的调控作用[J].体育科学,2012,32(1):64-70.
[14]石琼.多氯联苯醌诱导细胞发生自噬以及自噬--凋亡转换的机制分析[D].重庆:西南大学,2017.
[15]Zhou Yong,Liang Xinyu,Chang Hui,et al.Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through akt-mtor pathway via endoplasmic reticulum stress[J].Cancer Science,2015,105(10):1279-1287.
[16]王袖和,童红霞,徐浩,等.Mtor信号通路及其对衰老的影响[J].神经解剖学杂志,2018(3):404-408.
[17]Zhao Fei,Huang Weiwei,Zhang Zhe,et al.Triptolide induces protective autophagy through activation of the camkkβ-ampk signaling pathway in prostate cancer cells[J].Oncotarget,2016,7(5):5366-5382.
[18]赵萍萍,要乐,蔚丹丹,等.P62蛋白功能及相关信号通路研究[J].生命科学,2018(1):100-106.
[19]Junghyun Lim,Lenard Lachenmayer M.,Shuai Wu,et al.Proteotoxic stress induces phosphorylation of p62/sqstm1 by ulk1 to regulate selective autophagic clearance of protein aggregates[J].Plos Genetics,2015,11(2):e1004987.
[20]Kraft L.J.,Dowler J,Manral P,et al.Size,organization and dynamics of soluble sqstm1 and lc3-sqstm1 complexes in living cells[J].Autophagy,2016,12(9):1660-1674.
[21]任汐鹰,刘勤献,王海英.P53与细胞死亡[J].中国生物化学与分子生物学报,2018,34(6):588-594.
[22]刘效磊,牛燕媚,傅力.自噬--运动改善胰岛素抵抗的新机制[J].生理科学进展,2013,44(3):237-240.
[23]Li F.H.,Li T.,Ai J.Y.,et al.Beneficial autophagic activities,mitochondrial function,and metabolic phenotype adaptations promoted by high-intensity interval training in a rat model[J].Frontiers in Physiology,2018(9):1-15.
[24]Rocha-Rodrigues S,Gon?§Alves I.O.,Beleza J,et al.Effects of endurance training on autophagy and apoptotic signaling in visceral adipose tissue of prolonged high fat diet-fed rats[J].European Journal of Nutrition,2017(Suppl 2):1-11.
[25]Brandt N,Gunnarsson T.P.,Bangsbo J,et al.Exercise and exercise training-induced increase in autophagy markers in human skeletal muscle[J].Physiol Rep,2018,6(7):e13651.
[26]Mejíaspe?a Y.,Estébanez B.,Rodriguezmiguelez P.,et al.Impact of resistance training on the autophagyinflammation-apoptosis crosstalk in elderly subjects[J].Aging,2017,9(2):408-418.
[27]Dethlefsen Maja M.,Kristensen Caroline M.,T?ndering Anna S.,et al.Impact of liver pgc-1αon exercise and exercise training-induced regulation of hepatic autophagy and mitophagy in mice on hff[J].Physiological Reports,2018,6(13):e13731.
[28]Kim Jeong-Seok,Lee Young-Hee,Yi Ho-Keun.Gradual downhill running improves age-related skeletal muscle and bone weakness:Implication of autophagy and bone morphogenetic proteins[J].Experimental Physiology,2016,101(12):1528.
[29]Youngjeon Lee,Joo-Heon Kim,Hong Yunkyung,et al.Prophylactic effects of swimming exercise on autophagy-induced muscle atrophy in diabetic rats[J].Laboratory Animal Research,2012,28(3):171-179.
[30]Ghareghani P,Shanaki M,Ahmadi S,et al.Aerobic endurance training improves nonalcoholic fatty liver disease(nafld)features via mir-33 dependent autophagy induction in high fat diet fed mice[J].Obesity Research&Clinical Practice,2017,26(5):169-171.
[31]Jamart C,Francaux M,Millet G.Y.,et al.Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running[J].Journal of Applied Physiology,2012,112(9):1529-1537.
[32]Kang R.,Zeh H J,Lotze M T,et al.The beclin-1 network regulates autophagy and apoptosis[J].Cell Death&Differentiation,2011,18(4):571.
[33]Jamart C,Naslain D,Gilson H,et al.Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state[J].Am J Physiol Endocrinol Metab,2013,305(8):E964-E974.
[34]王倩,张珊,牛燕媚,等.高强度间歇运动与中等强度持续运动对小鼠代谢表型及骨骼肌自噬影响的对比研究[J].中国运动医学杂志,2018(2):138-142.
[35]Kou X.,Li J.,Liu X.,et al.Swimming attenuates d-galactose-induced brain aging via suppressing mir-34amediated autophagy impairment and abnormal mitochondrial dynamics[J].Journal of Applied Physiology,2017,122(6):18.
[36]Alex Sheril,Boss Andreas,Heerschap Arend,et al.Exercise training improves liver steatosis in mice[J].Nutrition&Metabolism,2015,12(1):29.
[37]Rosa-Caldwell M.E.,Lee D.E.,Brown J.L.,et al.Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice[J].Appl Physiol Nutr Metab,2017,42(2):148-156.