苦碟子注射液治疗冠心病不稳定型心绞痛的临床研究
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摘要
目的:研究冠心病不稳定型心绞痛(UA)患者采用苦碟子注射液佐治的疗效及影响。方法:对我院收治的UA患者120例,随机法分为观察组与对照组,每组60例。对照组仅予以心内科常规治疗,观察组则在常规治疗基础上,加用苦碟子注射液治疗,观察和对比两组的临床疗效。结果:治疗2周后,两组的中医证候评分、心绞痛症状(发作频率、发作持续时间)以及硝酸甘油消耗量均与治疗前相比明显降低,且观察组降低幅度高于对照组,组间比较差异显著(P <0.05);观察组综合疗效总有效率为96.67%(58/60),较对照组的78.33%(47/60)明显提高(P <0.05)。结论:UA采用苦碟子注射液佐治能够有效调节血脂水平、改善心电图并提高临床疗效,具有良好的临床推广应用价值。
Objective: To study the effect and influence of the Kudiezi injection( 苦 碟 子 注 射 液) on unstable angina. Methods: 120 patients were randomly divided into the observation group and the control group, 60 cases in each group. The control group was given routine treatment of cardiology; the observation group was treated with the Kudiezi injection more. The effects in two groups were observed and compared. Results: The scores of TCM syndromes, angina pectoris symptoms(attack frequency, attack duration) and nitroglycerin consumption in groups were significantly lower than those before treatment, and the decrease rates in the observation group were higher than the control group; the difference was significant(P<0.05). The total efficiency in the observation group was 96.67%, and significantly higher than 78.33% in the control group(P<0.05). Conclusion: The Kudiezi injection on UA can effectively regulate blood lipid level, improve electrocardiogram and clinical efficacy, and show good application value.
Objective: To study the effect and influence of the Kudiezi injection( 苦 碟 子 注 射 液) on unstable angina. Methods: 120 patients were randomly divided into the observation group and the control group, 60 cases in each group. The control group was given routine treatment of cardiology; the observation group was treated with the Kudiezi injection more. The effects in two groups were observed and compared. Results: The scores of TCM syndromes, angina pectoris symptoms(attack frequency, attack duration) and nitroglycerin consumption in groups were significantly lower than those before treatment, and the decrease rates in the observation group were higher than the control group; the difference was significant(P<0.05). The total efficiency in the observation group was 96.67%, and significantly higher than 78.33% in the control group(P<0.05). Conclusion: The Kudiezi injection on UA can effectively regulate blood lipid level, improve electrocardiogram and clinical efficacy, and show good application value.
引文
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[7]赵涛,赵步长,伍海勤,等.丹红注射液治疗气滞血瘀证的研究进展[J].中医临床研究,2014,6(27):39-41.
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[9]贾德武,罗胜勇,叶寿山,等.苦碟子总黄酮对脑缺血性损伤保护作用的实验研究[J].中国临床药理学与治疗学,2011,16(6):616-620.
[10]陶贵周,李云霞.苦碟子对不稳定型心绞痛患者血脂影响及临床疗效观察[J].广东医学,2010,31(7):910-912.
[2]洪敬党.中西医结合治疗冠心病不稳定型心绞痛临床观察[J].中国中医急症,2014,23(9):1736-1737.
[3]姜志男.不稳定型心绞痛中医证型与CAG结果及血脂水平等因素的相关性研究[D].沈阳:辽宁中医药大学,2017.
[4]中华人民共和国卫生部.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:68-73.
[5]王新安.苦碟子注射液治疗不稳定性心绞痛临床观察[J].中医临床研究,2011,3(9):27-28.
[6]刘珊珊,吴伟,卿立金.中西医结合调节血脂代谢的探讨[J].中国中西医结合杂志,2015,35(2):247-249.
[7]赵涛,赵步长,伍海勤,等.丹红注射液治疗气滞血瘀证的研究进展[J].中医临床研究,2014,6(27):39-41.
[8]梁凤兰,李争,戚丹凤,等.益气化痰通瘀汤对冠心病心绞痛患者血脂的影响[J].中国中医药现代远程教育,2015,13(14):27-29.
[9]贾德武,罗胜勇,叶寿山,等.苦碟子总黄酮对脑缺血性损伤保护作用的实验研究[J].中国临床药理学与治疗学,2011,16(6):616-620.
[10]陶贵周,李云霞.苦碟子对不稳定型心绞痛患者血脂影响及临床疗效观察[J].广东医学,2010,31(7):910-912.