摘要
手性药物的对映体由于空间结构不同,在生物体内结合的受体不同,导致其在药理和药效上有很大的差异,因此对手性药物进行手性拆分分析研究有着非常重要的现实意义。本文综述了2000年来环糊精及其衍生物作为手性流动相添加剂在高效液相色谱法中分离手性药物的应用情况。
Different enantiomers of asymmetric drugs possess significant differences in the pharmacology and pharmacodynamics because of the various biological receptors binding with the various space structures of the drug molecules in organisms.Thus,it is very important to carry on the chiral resolution of corresponding isomer.In this paper,the applications of cyclodextrin and its derivatives used as chiral mobile phase additives in separation of chiral drugs by high performance liquid chromatography after 2000 were summarized.
引文
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