环糊精及其衍生物在手性药物分离中的应用
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摘要
手性药物的对映体由于空间结构不同,在生物体内结合的受体不同,导致其在药理和药效上有很大的差异,因此对手性药物进行手性拆分分析研究有着非常重要的现实意义。本文综述了2000年来环糊精及其衍生物作为手性流动相添加剂在高效液相色谱法中分离手性药物的应用情况。
Different enantiomers of asymmetric drugs possess significant differences in the pharmacology and pharmacodynamics because of the various biological receptors binding with the various space structures of the drug molecules in organisms.Thus,it is very important to carry on the chiral resolution of corresponding isomer.In this paper,the applications of cyclodextrin and its derivatives used as chiral mobile phase additives in separation of chiral drugs by high performance liquid chromatography after 2000 were summarized.
Different enantiomers of asymmetric drugs possess significant differences in the pharmacology and pharmacodynamics because of the various biological receptors binding with the various space structures of the drug molecules in organisms.Thus,it is very important to carry on the chiral resolution of corresponding isomer.In this paper,the applications of cyclodextrin and its derivatives used as chiral mobile phase additives in separation of chiral drugs by high performance liquid chromatography after 2000 were summarized.
引文
[1]谭思师,王朝阳.非手性柱高效液相色谱法拆分盐酸西布曲明[J].安徽化工,2007,33(4):33-35.
[2]詹少卿,何振伟,张冬梅等.高效液相色谱手性添加剂法测定特布他林对映体血药浓度[J].药学与临床研究,2008,16(8): 460-462.
[3]Sakalgaonkar A A.Mirgane S R.Pawar R P.Validated LC Method with a Chiral Mobile Phase,for Separation of the Isomers of Fexofenadine Hydrochloride[J].Chromatography,2008,68(1-2):143-146.
[4]El-Gindy A.Emara S,Mesbah M K et al.Liquid Chromatography Determination of Citalopram Enantiomers Using Beta-Cyclodextrin as a Chiral Mobile Phase Additive[J].J AOAC 7ni.2006,89(1):65-70.
[5]胡珊珊,吴怡祖,史美仁.β-环糊精手性流动相HPLC法拆分α-环己基扁桃酸对映体[J].精细化工,2004,21(i0): 731-732,740.
[6]李成平,施介华,单伟光.高效液相色谱手性流动相添加剂法拆分麻黄碱对映体[J].华西药学杂志,2004,19(5):333-335.
[7]徐颖,邓小燕,李树刚等.β环糊精手性流动相添加剂法拆分佐匹克隆对映体[J].药学进展,2006,30(9):418-421.
[8]张丹丹,郭兴杰,袁波等.高效液相色谱手性流动相舔加剂分离西孟坦对映体[J].分析化学.2004,32(2):229-231.
[9]哈婧,杨丽荣,张炳烛.手性流动相HPLC法拆分对羟基苯甘氨酸对映体的研究[刀.分析试验室,2008,27(2):70-72.
[10]李成平,严小平,许惠英等.高效液相色谱手性流动相添加剂法拆分酪氨酸甲酯对映体[J].理化检验(化学分册),2004,40 (6):329-330,333.
[11]陈磊,万谦宏.雌马醇对映体的高效液相色谱分离[J].药物分析杂志,2006,26(6):795-798
[12]Yeole R D,Jadhav A S.Patil K R et al.Validated Chiral High-Performance Liquid Chromatography Method for a Novel AntiMethicillin -Resistant Staphylococcus Aureus Fluoroquinolone WCK 77l[J].J.Chromatogr.A,2006,1108(1),38-42.
[13]杨丽,江树人,廖勇.流动相添加剂法与手性固定相法对己唑醇光学异构体的拆分[J].农药学学报,2004,6(2):90-92.
[14]于金刚,黄可龙,刘素琴等.高效液相色谱手性流动相添加剂法拆分氯噻酮对映体[J].分析试验室,2005,24(11):22-24.
[15]宁凤容,黄可龙,焦飞鹏.HP-β-CD手性流动相HPLC法拆分萘普生对映体的色谱保留机制和拆分机理研究[J].化学通报, 2006,69(6):425-429.
[16]郭娜,高新星,徐国防等.高效液相色谱手性流动相添加法拆分奥昔布宁对映体[J].色谱,2008,26(2):259-261.
[17]高玉玲,吴照义,苏立强.HPLC手性流动相添加剂法拆分盐酸美西律对映体[J].化学工程师,2008,157(10):9-11.
[18]李成平,施青红,李立等.高效液相色谱手性流动相法拆分布洛芬对映体[J].药物分析杂志,2005,25(4):426-428.
[19]Ye J C.Chen G S.Zeng S.Enantiomeric Separation Of Norgestrel by Reversed Phase High-Performance Liquid Chromatography Using Eluents Containing Hydroxylpropyl Beta-Cyclodextrin in Stereoselective Skin Permeation Study[J].J.Chromatogr.5,2006, 843(2):289-294.
[20]李成平,施介华,单伟光等.美托洛尔对映体的高效液相色谱拆分[J].药物分析杂志,2006,2S(5):493-495.
[21]阮源萍,郑子达,张雪曼等.手性流动相添加剂高效液相色谱法分离苯基琥珀酸对映体[J].分析测试学报,2004,23(1): 55-57.
[22]杨青,唐瑞仁,曾莎莎.高效液相色谱手性流动相法拆分酮基布洛芬对映体[J].分析试验室,2007,26(8):84-86.
[23]白冬梅,赵学明,胡宗定.高效液相色谱手性流动相添加剂分离乳酸对映体[J].分析化学,2001,29(4):413-415.
[24]关瑾,杨晶,石爽等.磺丁基醚-β-环糊精手性流动相添加剂法分离兰索拉唑对映体[J].分析试验室,2009,28(2):91-93.
[25]卢铁刚,杨茂俊.羧甲基-β-环糊精手性流动相添加剂法拆分帕罗西汀及其中间体对映体[J].色谱,2007,25(6):830-833.
[26]牛长群,任雷鸣.3种新型α-受体阻断剂的手性流动相HPLC分离与制备[J].药学学报,2002,37(6):450-453.
[2]詹少卿,何振伟,张冬梅等.高效液相色谱手性添加剂法测定特布他林对映体血药浓度[J].药学与临床研究,2008,16(8): 460-462.
[3]Sakalgaonkar A A.Mirgane S R.Pawar R P.Validated LC Method with a Chiral Mobile Phase,for Separation of the Isomers of Fexofenadine Hydrochloride[J].Chromatography,2008,68(1-2):143-146.
[4]El-Gindy A.Emara S,Mesbah M K et al.Liquid Chromatography Determination of Citalopram Enantiomers Using Beta-Cyclodextrin as a Chiral Mobile Phase Additive[J].J AOAC 7ni.2006,89(1):65-70.
[5]胡珊珊,吴怡祖,史美仁.β-环糊精手性流动相HPLC法拆分α-环己基扁桃酸对映体[J].精细化工,2004,21(i0): 731-732,740.
[6]李成平,施介华,单伟光.高效液相色谱手性流动相添加剂法拆分麻黄碱对映体[J].华西药学杂志,2004,19(5):333-335.
[7]徐颖,邓小燕,李树刚等.β环糊精手性流动相添加剂法拆分佐匹克隆对映体[J].药学进展,2006,30(9):418-421.
[8]张丹丹,郭兴杰,袁波等.高效液相色谱手性流动相舔加剂分离西孟坦对映体[J].分析化学.2004,32(2):229-231.
[9]哈婧,杨丽荣,张炳烛.手性流动相HPLC法拆分对羟基苯甘氨酸对映体的研究[刀.分析试验室,2008,27(2):70-72.
[10]李成平,严小平,许惠英等.高效液相色谱手性流动相添加剂法拆分酪氨酸甲酯对映体[J].理化检验(化学分册),2004,40 (6):329-330,333.
[11]陈磊,万谦宏.雌马醇对映体的高效液相色谱分离[J].药物分析杂志,2006,26(6):795-798
[12]Yeole R D,Jadhav A S.Patil K R et al.Validated Chiral High-Performance Liquid Chromatography Method for a Novel AntiMethicillin -Resistant Staphylococcus Aureus Fluoroquinolone WCK 77l[J].J.Chromatogr.A,2006,1108(1),38-42.
[13]杨丽,江树人,廖勇.流动相添加剂法与手性固定相法对己唑醇光学异构体的拆分[J].农药学学报,2004,6(2):90-92.
[14]于金刚,黄可龙,刘素琴等.高效液相色谱手性流动相添加剂法拆分氯噻酮对映体[J].分析试验室,2005,24(11):22-24.
[15]宁凤容,黄可龙,焦飞鹏.HP-β-CD手性流动相HPLC法拆分萘普生对映体的色谱保留机制和拆分机理研究[J].化学通报, 2006,69(6):425-429.
[16]郭娜,高新星,徐国防等.高效液相色谱手性流动相添加法拆分奥昔布宁对映体[J].色谱,2008,26(2):259-261.
[17]高玉玲,吴照义,苏立强.HPLC手性流动相添加剂法拆分盐酸美西律对映体[J].化学工程师,2008,157(10):9-11.
[18]李成平,施青红,李立等.高效液相色谱手性流动相法拆分布洛芬对映体[J].药物分析杂志,2005,25(4):426-428.
[19]Ye J C.Chen G S.Zeng S.Enantiomeric Separation Of Norgestrel by Reversed Phase High-Performance Liquid Chromatography Using Eluents Containing Hydroxylpropyl Beta-Cyclodextrin in Stereoselective Skin Permeation Study[J].J.Chromatogr.5,2006, 843(2):289-294.
[20]李成平,施介华,单伟光等.美托洛尔对映体的高效液相色谱拆分[J].药物分析杂志,2006,2S(5):493-495.
[21]阮源萍,郑子达,张雪曼等.手性流动相添加剂高效液相色谱法分离苯基琥珀酸对映体[J].分析测试学报,2004,23(1): 55-57.
[22]杨青,唐瑞仁,曾莎莎.高效液相色谱手性流动相法拆分酮基布洛芬对映体[J].分析试验室,2007,26(8):84-86.
[23]白冬梅,赵学明,胡宗定.高效液相色谱手性流动相添加剂分离乳酸对映体[J].分析化学,2001,29(4):413-415.
[24]关瑾,杨晶,石爽等.磺丁基醚-β-环糊精手性流动相添加剂法分离兰索拉唑对映体[J].分析试验室,2009,28(2):91-93.
[25]卢铁刚,杨茂俊.羧甲基-β-环糊精手性流动相添加剂法拆分帕罗西汀及其中间体对映体[J].色谱,2007,25(6):830-833.
[26]牛长群,任雷鸣.3种新型α-受体阻断剂的手性流动相HPLC分离与制备[J].药学学报,2002,37(6):450-453.