比索洛尔联合苯那普利对脑出血后室性心律失常的疗效观察
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摘要
目的分析比索洛尔联合苯那普利对脑出血后室性心律失常的治疗效果。方法选取2016年5月至2017年6月荣成市人民医院收治的60例脑出血后室性心律失常患者,按随机数表法分为对照组与研究组。对照组患者接受比索洛尔治疗,研究组患者接受比索洛尔联合苯那普利治疗。采用24 h动态心电图对患者用药治疗前后心率、室性期前收缩次数进行监测,于治疗前后进行NIHSS评分。结果治疗后,两组患者心率均较治疗前降低(P <0. 05),研究组患者心率低于对照组(P <0. 05)。研究组患者治疗后室性期前收缩的发生次数低于对照组,差异有统计学意义(P <0. 05)。治疗后,两组患者NIHSS评分均较治疗前降低(P <0. 05);观察组治疗后NIHSS评分低于对照组(P <0. 05)。结论比索洛尔联合苯那普利可以减少脑出血后室性心律失常患者室性期前收缩发生次数,有效治疗脑出血后室性心律失常,有利于神经功能的改善,可以进一步推广应用。
Objective To analyze the effect of bisoprolol combined with benazepril on ventricular arrhythmia after intracerebral hemorrhage. Methods Sixty patients with ventricular arrhythmia after intracerebral hemorrhage admitted to Rongcheng People 's Hospital from May of 2016 to June of 2017 were randomly divided into control group and research group. The control group was treated with bisoprolol and the study group was treated with bisoprolol combined with benazepril. The heart rate and the number of ventricular premature contractions were monitored by 24-hour dynamic electrocardiogram before and after treatment. The NIHSS score was evaluated before and after treatment. Results After treatment,the heart rate of the two groups was lower than that before treatment( P < 0. 05),and the heart rate of the study group was lower than that of the control group( P < 0. 05). The incidence of ventricular premature contraction in the study group was lower than that in the control group after treatment( P < 0. 05). After treatment,the NIHSS scores of the two groups were lower than those before treatment( P < 0. 05); the NIHSS scores of the observation group were lower than those of the control group after treatment( P < 0. 05). Conclusion Bisoprolol combined with benazepril can reduce the occurrence of ventricular premature contraction in patients with ventricular arrhythmia after intracerebral hemorrhage,effectively treat ventricular arrhythmia after intracerebral hemorrhage,which is conducive to the improvement of nerve function,and can be further popularized and applied.
Objective To analyze the effect of bisoprolol combined with benazepril on ventricular arrhythmia after intracerebral hemorrhage. Methods Sixty patients with ventricular arrhythmia after intracerebral hemorrhage admitted to Rongcheng People 's Hospital from May of 2016 to June of 2017 were randomly divided into control group and research group. The control group was treated with bisoprolol and the study group was treated with bisoprolol combined with benazepril. The heart rate and the number of ventricular premature contractions were monitored by 24-hour dynamic electrocardiogram before and after treatment. The NIHSS score was evaluated before and after treatment. Results After treatment,the heart rate of the two groups was lower than that before treatment( P < 0. 05),and the heart rate of the study group was lower than that of the control group( P < 0. 05). The incidence of ventricular premature contraction in the study group was lower than that in the control group after treatment( P < 0. 05). After treatment,the NIHSS scores of the two groups were lower than those before treatment( P < 0. 05); the NIHSS scores of the observation group were lower than those of the control group after treatment( P < 0. 05). Conclusion Bisoprolol combined with benazepril can reduce the occurrence of ventricular premature contraction in patients with ventricular arrhythmia after intracerebral hemorrhage,effectively treat ventricular arrhythmia after intracerebral hemorrhage,which is conducive to the improvement of nerve function,and can be further popularized and applied.
引文
[1]蒋芳萍,宁靓,杨波.比索洛尔联合常规三联疗法对风湿性心脏瓣膜病合并慢性心力衰竭患者疗效及相关指标的影响[J].中国药房,2016,27(18):2511-2513.
[2]Tran T V,Cortez D. Clinical Application of the QRS-T Angle for the Prediction of Ventricular Arrhythmias in Patients with the Fontan Palliation[J]. Pediatr Cardiol,2017,38(5):1-8.
[3]张冬梅,张后民.胺碘酮联用比索洛尔对左室肥厚的高血压患者QTd及VA的影响研究[J].重庆医学,2016,45(25):3546-3548.
[4]刘军.富马酸比索洛尔对慢性肺源性心脏病心律失常患者脑钠肽和C反应蛋白水平的影响[J].中国老年学杂志,2016,36(9):7-9.
[5]师帅,耿彦婷,胡元会,等.稳心颗粒联合比索洛尔治疗心力衰竭合并心律失常的系统评价[J].中国实验方剂学杂志,2016,64(15):216-219.
[6]王云鹏,张云,孙一荣,等.尼可地尔对急性ST段抬高型心肌梗死患者行急诊经皮冠状动脉介入治疗后室性心律失常的影响[J].中华心血管病杂志,2017,45(8):701-705.
[7]胥良.美托洛尔应用于高血压性心脏病患者对其QT间期离散度及室性心律失常的影响[J].重庆医学,2017,32(A03):325-327.
[8]陈传俊,韩永生,陈晨,等.早期复极及其形态与STEMI患者发生室性心律失常的关系[J].山东医药,2017,57(17):45-47.
[9]Deniz A,Demir M.[Comments on 2015 ESC Guidelines for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death][J]. Turk Kardiyol Dern Ars,2016,44(1):9-14.
[10]双跃华,毛振立,于林.醒脑静注射液在高血压脑出血患者微创血肿清除术后康复中的应用效果观察[J].山东医药,2017,57(12):93-95.
[11]Kautzner J,Osmancˇík P. Summary of the 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Prepared by the Czech Society of Cardiology[J]. Revista Espa1ola De Cardiologiía,2016,69(2):176-177.
[12]刘吉园,牛小伟,张益铭,等.急性ST段抬高型心肌梗死患者介入治疗前后T波峰末间期的变化过程及其与恶性室性心律失常的关系[J].中国循环杂志,2017,32(2):132-136.
[2]Tran T V,Cortez D. Clinical Application of the QRS-T Angle for the Prediction of Ventricular Arrhythmias in Patients with the Fontan Palliation[J]. Pediatr Cardiol,2017,38(5):1-8.
[3]张冬梅,张后民.胺碘酮联用比索洛尔对左室肥厚的高血压患者QTd及VA的影响研究[J].重庆医学,2016,45(25):3546-3548.
[4]刘军.富马酸比索洛尔对慢性肺源性心脏病心律失常患者脑钠肽和C反应蛋白水平的影响[J].中国老年学杂志,2016,36(9):7-9.
[5]师帅,耿彦婷,胡元会,等.稳心颗粒联合比索洛尔治疗心力衰竭合并心律失常的系统评价[J].中国实验方剂学杂志,2016,64(15):216-219.
[6]王云鹏,张云,孙一荣,等.尼可地尔对急性ST段抬高型心肌梗死患者行急诊经皮冠状动脉介入治疗后室性心律失常的影响[J].中华心血管病杂志,2017,45(8):701-705.
[7]胥良.美托洛尔应用于高血压性心脏病患者对其QT间期离散度及室性心律失常的影响[J].重庆医学,2017,32(A03):325-327.
[8]陈传俊,韩永生,陈晨,等.早期复极及其形态与STEMI患者发生室性心律失常的关系[J].山东医药,2017,57(17):45-47.
[9]Deniz A,Demir M.[Comments on 2015 ESC Guidelines for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death][J]. Turk Kardiyol Dern Ars,2016,44(1):9-14.
[10]双跃华,毛振立,于林.醒脑静注射液在高血压脑出血患者微创血肿清除术后康复中的应用效果观察[J].山东医药,2017,57(12):93-95.
[11]Kautzner J,Osmancˇík P. Summary of the 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Prepared by the Czech Society of Cardiology[J]. Revista Espa1ola De Cardiologiía,2016,69(2):176-177.
[12]刘吉园,牛小伟,张益铭,等.急性ST段抬高型心肌梗死患者介入治疗前后T波峰末间期的变化过程及其与恶性室性心律失常的关系[J].中国循环杂志,2017,32(2):132-136.