清热化瘀散联合微生态制剂对重症肺炎患儿合并胃肠功能障碍的疗效观察
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摘要
目的:观察清热化瘀散联合微生态制剂对重症肺炎合并胃肠功能障碍患儿的治疗效果。方法:选择2014年至2017年河北省儿童医院收治的100例重症肺炎合并胃肠功能障碍患儿作为研究对象,随机分为对照组和观察组,每组50例。其中对照组给予常规综合治疗,观察组在常规综合治疗基础上给予清热化瘀散联合双歧杆菌三联活菌胶囊,比较两组患儿的胃肠道临床症状、治疗前后胃肠相关功能指标、胃肠功能障碍与衰竭(GIDF)评分以及氧合指数(PiO_2/FiO_2)变化,观察两组患儿的临床疗效差异。结果:观察组患儿治疗后其中医症状消失时间、返流呕吐消失时间以及平均住院时间显著低于对照组(P<0.01)。与治疗前比较,治疗后两组患儿的胃泌素(GAS)、二胺氧化酶(DAO)、D-乳酸、GIDF评分均显著降低(P<0.01),胃动素(MOT)含量及PiO_2/FiO_2显著升高(P<0.05,P<0.01),且观察组患儿上述指标改善更为显著(P<0.01)。观察组患儿的治疗总有效率为96.00%,显著高于对照组(84.00%)(P<0.05)。结论:清热化瘀散联合双歧杆菌三联活菌胶囊治疗重症肺炎合并胃肠功能障碍患儿,可以有效改善胃肠道功能,同时起到对重症肺炎的治疗作用。
Objective: To observe the therapeutic effect of Qingre Huayu Powder combined with microecological preparations on children with severe pneumonia complicated with gastrointestinal dysfunction. Methods: A total of 100 children with severe pneumonia complicated with gastrointestinal dysfunction admitted to Children's Hospital of Hebei Province from2014 to 2017 were selected as random subjects. Divided into control group and observation group, 50 cases each. The control group was given conventional comprehensive treatment. The observation group was given Qingre Huayu Powder combined with Bifid-triple Viable Capsule on the above basis. The clinical symptoms of gastrointestinal tract of the two groups were compared,and the changes of gastrointestinal dysfunction and failure(GIDF) score and oxygenation index(PiO_2/FiO_2) before and after treatment were compared, so as to observe the differences in clinical efficacy between the two groups. Results: After treatment,TCM symptoms disappear time, reflux vomiting disappear time, and the average length of hospital stay of children in observation group were significantly lower than in the control group(P<0.01). After treatment, two groups of children with stomach gastrinreleasing(GAS), diamine oxidase(DAO), D-lactic acid, GIDF scores were significantly lower(P<0.01), moving element(MOT)content and PiO_2/FiO_2 increased significantly(P<0.05, P<0.01), while the observation group the above indicators improved more significantly(P<0.01). The treatment efficiency of the observation group was 96.00%, significantly higher than that of the control group which was 84.00%(P<0.05). Conclusion: Qingre Huayu Powder combined with Bifid-triple Viable Capsule in the treatment of severe pneumonia complicated with gastrointestinal dysfunction, can effectively improve the function of the gastrointestinal tract and at the same time play a therapeutic role in severe pneumonia.
Objective: To observe the therapeutic effect of Qingre Huayu Powder combined with microecological preparations on children with severe pneumonia complicated with gastrointestinal dysfunction. Methods: A total of 100 children with severe pneumonia complicated with gastrointestinal dysfunction admitted to Children's Hospital of Hebei Province from2014 to 2017 were selected as random subjects. Divided into control group and observation group, 50 cases each. The control group was given conventional comprehensive treatment. The observation group was given Qingre Huayu Powder combined with Bifid-triple Viable Capsule on the above basis. The clinical symptoms of gastrointestinal tract of the two groups were compared,and the changes of gastrointestinal dysfunction and failure(GIDF) score and oxygenation index(PiO_2/FiO_2) before and after treatment were compared, so as to observe the differences in clinical efficacy between the two groups. Results: After treatment,TCM symptoms disappear time, reflux vomiting disappear time, and the average length of hospital stay of children in observation group were significantly lower than in the control group(P<0.01). After treatment, two groups of children with stomach gastrinreleasing(GAS), diamine oxidase(DAO), D-lactic acid, GIDF scores were significantly lower(P<0.01), moving element(MOT)content and PiO_2/FiO_2 increased significantly(P<0.05, P<0.01), while the observation group the above indicators improved more significantly(P<0.01). The treatment efficiency of the observation group was 96.00%, significantly higher than that of the control group which was 84.00%(P<0.05). Conclusion: Qingre Huayu Powder combined with Bifid-triple Viable Capsule in the treatment of severe pneumonia complicated with gastrointestinal dysfunction, can effectively improve the function of the gastrointestinal tract and at the same time play a therapeutic role in severe pneumonia.
引文
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[10]莫芳芳,马师雷,李鸿涛,等.基于中医古籍研究的“肺与大肠相表里”理论源流及其内涵探讨.环球中医药,2015,8(2):165-168
[11]华华,王军,胡鑫,等.基于物质相关性探讨“肺与大肠相表里”理论研究进展.辽宁中医药大学学报,2015,17(5):164-166
[12]Jroundi I,Mahraoui C,Benmessaoud R,et al.A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children.Epidemiology&Infection,2016,144(3):516-526
[2]0thman H T,Abu Elhamed W A,Hassan D M,et al.Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two.J Infect Dev ctries,2016,10(3):283-289
[3]Ntuli S T,Malangu N,Alberts M.Causes of deaths in children underfive years old at a tertiary hospital in Limpopo province of south Africa.Glob J Health Sci,2013,5(3):95-100
[4]Ho M C,Ker C R,Hsu J H,et al.Usefulness of lung ultrasound in the diagnosis of community-acquired pneumonia in children.Pediatrics&Neonatology,2015,56(1):40-45
[5]Pac M,Bernatowska E A,Kierku?J,et al.Gastrointestinal disorders next to respiratory infections as leading symptoms of X-linked agammaglobulinemia in children-34-year experience of a single center.Archives of Medical Science Ams,2017,13(2):412-417
[6]张英谦,郝京霞,郭鹏,等.依据中医“肺与大肠相表里”采用中西医结合治疗重症肺炎患儿疗效观察.中国中医急症,2017,26(3):487-490
[7]朱桂松,吴同启,傅元冬,等.芎黄合剂治疗重症肺炎合并胃肠功能障碍临床观察.中国中西医结合杂志,2017,37(8):909-912
[8]郑秀丽,杨宇,王宝家,等.从病理状态下肺功能与胃肠功能的变化探讨“肺与大肠相表里”.中华中医药杂志,2014,29(1):120-123
[9]郝京霞,张英谦,黄波,等.肺与大肠相表里应用到肺疾病治疗中的理论研究进展.中华中医药杂志,2017,32(4):1688-1690
[10]莫芳芳,马师雷,李鸿涛,等.基于中医古籍研究的“肺与大肠相表里”理论源流及其内涵探讨.环球中医药,2015,8(2):165-168
[11]华华,王军,胡鑫,等.基于物质相关性探讨“肺与大肠相表里”理论研究进展.辽宁中医药大学学报,2015,17(5):164-166
[12]Jroundi I,Mahraoui C,Benmessaoud R,et al.A comparison of human metapneumovirus and respiratory syncytial virus WHO-defined severe pneumonia in Moroccan children.Epidemiology&Infection,2016,144(3):516-526