重庆市2805例健康女性DXA法骨密度现况分析
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摘要
目的:通过测量重庆市2 805人次健康女性骨密度,初步建立重庆地区各年龄段骨密度数据库及骨峰值,并探讨年龄、体质量指数对骨密度变化的影响。方法:选取2011年6月至2015年11月在重庆市妇幼保健院体检的健康女性,采用双能X线骨密度仪测量腰椎1~4和股骨颈骨密度。结果:2 805例健康女性骨质疏松症发生率为11.44%;随着年龄增长,骨质疏松症比例增加(趋势卡方检验:χ2=403.800,P=0.000);50岁以上骨质疏松症发生率为26.04%,50岁前后的正常骨量和骨质疏松症比例均有统计学差异(P=0.000);35~39岁达到腰椎1~4骨密度峰值(1.116±0.120)g/cm2,17~19岁达到股骨颈骨密度峰值(0.935±0.146)g/cm2。结论:本研究建立了重庆市经DXA法测量腰椎及股骨颈骨密度的大数据。
Objective:To establish a preliminary bone mineral density(BMD)database and the peak BMD of people from different age groups in Chongqing,China,through the measurement of BMD in 2 805 healthy women in Chongqing,and to investigate the effect of age and body mass index on BMD. Methods:Dual-energy X-ray absorptiometry(DXA)was used to determine the BMD of the lumbar vertebrae(L1-4)and the femoral neck of healthy women who had physical examinations in Chongqing Health Center for Women and Children from June 2011 to November 2015. Results:The prevalence rate of osteoporosis in 2 805 healthy women was 11.44%,and it increased with age(χ2=403.800,P=0.000). The prevalence rate of osteoporosis in women over 50 years of age was 26.04%;there were significant differences in the proportions of women with normal bone mass and osteoporosis before and after the age of 50 years(P=0.000). The peak BMD(1.116±0.120)g/cm2 of lumbar vertebrae was reached at the age of 35 to 39 years,and the peak BMD(0.935±0.146)g/cm2 of femoral neck was reached at the age of 17 to 19 years. Conclusion:In this study,a DXA-measured BMD database of lumbar vertebrae and femoral neck of people in Chongqing was established.
Objective:To establish a preliminary bone mineral density(BMD)database and the peak BMD of people from different age groups in Chongqing,China,through the measurement of BMD in 2 805 healthy women in Chongqing,and to investigate the effect of age and body mass index on BMD. Methods:Dual-energy X-ray absorptiometry(DXA)was used to determine the BMD of the lumbar vertebrae(L1-4)and the femoral neck of healthy women who had physical examinations in Chongqing Health Center for Women and Children from June 2011 to November 2015. Results:The prevalence rate of osteoporosis in 2 805 healthy women was 11.44%,and it increased with age(χ2=403.800,P=0.000). The prevalence rate of osteoporosis in women over 50 years of age was 26.04%;there were significant differences in the proportions of women with normal bone mass and osteoporosis before and after the age of 50 years(P=0.000). The peak BMD(1.116±0.120)g/cm2 of lumbar vertebrae was reached at the age of 35 to 39 years,and the peak BMD(0.935±0.146)g/cm2 of femoral neck was reached at the age of 17 to 19 years. Conclusion:In this study,a DXA-measured BMD database of lumbar vertebrae and femoral neck of people in Chongqing was established.
引文
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[8]van Leeuwen J,Koes BW,Paulis WD,et al.Differences in bone mineral density between normal-weight children and children with overweight and obesity:a systematic review and meta-analysis[J].Obes Rev,2017,18(5):526-546.
[9]Grgurevic A,Gledovic Z,Vujasinovic-Stupar N.Factor associated with postmenopausal osteoporosis:a case-control study of Belgrade women[J].Women Health,2010,50(5):475-490.
[10]Bijelic R,Balaban M,Milicevic S.Gender representation of osteoporosis in patients with Urolithiasis[J].Med Arch,2015,69(5):331-333.
[11]Lee N,Kim J.A review of the effect of swim training and nutrition on bone mineral density in female athletes[J].J Exerc Nutrition Biochem,2015,19(4):273-279.
[12]Di Monaco M,Castiglioni C,Tappero R,et al.Parathyroid hormone response to severe vitamin D deficiency is associated with femoral neck bone mineral density:an observational study of 405 women with hipfracture[J].Hormones(Athens),2016,15(4):527-533.
[13]Pompe E,Bartstra J,Verhaar HJ,et al.Bone density loss on computed tomography at 3-year follow-up in current compared to former male smokers[J].Eur J Radiol,2017,89(4):177-181.
[2]伍贤平,廖二元,刘忠厚.不同国家和地区各种族人群骨密度参考值及其相互比较[J].中国骨质疏松杂志,2007,13(1):1-21.
[3]Si L,Winzenberg TM,Jiang Q,et al.Projection of osteoporosis-related fractures and costs in China:2010-2050[J].Osteoporos Int,2015,26(7):1929-1937.
[4]Veronese N,Stubbs B,Crepaldi G,et al.Relationship between low bone mineral density and fractures with incident cardiovascular disease:a systematic review and meta-analysis[J].J Bone Miner Res,2017,32(5):1126-1135.
[5]Bijelic R,Balaban J,Milicevic S.Correlation of the lipid profile,BMI and bone mineral density in postmenopausal women[J].Mater Sociomed,2016,28(6):412-415.
[6]Fornari R,Francomano D,Greco EA,et al.Lean mass in obese adult subjects correlates with higher levels of vitamin D,insulin sensitivity and lower inflammation[J].J Endocrinol Invest,2015,38(3):367-372.
[7]Asokan AG,Jaganathan J,Philip R,et al.Evaluation of bone mineral density among type 2 diabetes mellitus patients in South Karnataka[J].J Nat Sci Biol Med,2017,8(1):94-98.
[8]van Leeuwen J,Koes BW,Paulis WD,et al.Differences in bone mineral density between normal-weight children and children with overweight and obesity:a systematic review and meta-analysis[J].Obes Rev,2017,18(5):526-546.
[9]Grgurevic A,Gledovic Z,Vujasinovic-Stupar N.Factor associated with postmenopausal osteoporosis:a case-control study of Belgrade women[J].Women Health,2010,50(5):475-490.
[10]Bijelic R,Balaban M,Milicevic S.Gender representation of osteoporosis in patients with Urolithiasis[J].Med Arch,2015,69(5):331-333.
[11]Lee N,Kim J.A review of the effect of swim training and nutrition on bone mineral density in female athletes[J].J Exerc Nutrition Biochem,2015,19(4):273-279.
[12]Di Monaco M,Castiglioni C,Tappero R,et al.Parathyroid hormone response to severe vitamin D deficiency is associated with femoral neck bone mineral density:an observational study of 405 women with hipfracture[J].Hormones(Athens),2016,15(4):527-533.
[13]Pompe E,Bartstra J,Verhaar HJ,et al.Bone density loss on computed tomography at 3-year follow-up in current compared to former male smokers[J].Eur J Radiol,2017,89(4):177-181.