头孢克肟治疗急性细菌性肠炎患者的临床效果及其对血清IL-8、PCT、TNF-α水平的影响
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摘要
目的探讨头孢克肟治疗急性细菌性肠炎患者的临床效果及其对血清白介素-8(IL-8)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)水平的影响。方法选取2017年4月至2018年7月在我院治疗的急性细菌性肠炎患者96例作为研究对象,随机分为观察组与对照组,每组48例。两组患者均进行常规治疗。在此基础上,对照组患者口服头孢克洛治疗,观察组患者口服头孢克肟治疗。两组患者均连续治疗7 d。比较两组患者的临床疗效以及腹泻情况;检测比较治疗前后两组患者的血清IL-8、PCT、TNF-α水平。结果治疗7 d后,观察组患者的治疗总有效率(97. 92%)显著高于对照组(72. 92%),腹泻次数显著少于对照组,血清IL-8、PCT以及TNF-α水平显著低于对照组,差异均有统计学意义(P <0. 05)。结论在常规治疗的基础上,应用头孢克肟治疗急性细菌性肠炎患者临床疗效确切,可有效改善患者腹泻症状,同时降低患者血清炎症因子水平。
Objective To explore the clinical efficacy of cefixime in patients with acute bacterial enteritis and its effect on serum Interleukin-8( IL-8),procalcitonin( PCT) and tumor necrosis factor-α( TNF-α) levels. Methods 96 patients with acute bacterial enteritis who were admitted to our hospital from April 2017 to July 2018 were selected as the research objects and randomly divided into observation group and control group,with 48 cases in each group. On the basis of conventional treatment,the observation group was treated with cefixime and control group was treated with cefaclor. Both groups were treated for 7 days. The clinical effects and diarrhea were compared between the two groups. The serum IL-8,PCT and TNF-α levels before and after treatment in the two groups were detected and compared. Results After 7 days of treatment,the total effective rate of observation group( 97. 92%) was significantly higher than that of the control group( 72. 92%),the diarrhea frequency was significantly less than that in the control group and the levels of serum IL-8,PCT and TNF-α were significantly lower than those in the control group,the difference was statistically significant( P < 0. 05).Conclusion On the basis of conventional treatment,cefixime is definite in clinical efficacy in treating patients with acute bacterial enteritis,which can effectively improve the symptoms of diarrhea and reduce the level of serum inflammatory factors.
Objective To explore the clinical efficacy of cefixime in patients with acute bacterial enteritis and its effect on serum Interleukin-8( IL-8),procalcitonin( PCT) and tumor necrosis factor-α( TNF-α) levels. Methods 96 patients with acute bacterial enteritis who were admitted to our hospital from April 2017 to July 2018 were selected as the research objects and randomly divided into observation group and control group,with 48 cases in each group. On the basis of conventional treatment,the observation group was treated with cefixime and control group was treated with cefaclor. Both groups were treated for 7 days. The clinical effects and diarrhea were compared between the two groups. The serum IL-8,PCT and TNF-α levels before and after treatment in the two groups were detected and compared. Results After 7 days of treatment,the total effective rate of observation group( 97. 92%) was significantly higher than that of the control group( 72. 92%),the diarrhea frequency was significantly less than that in the control group and the levels of serum IL-8,PCT and TNF-α were significantly lower than those in the control group,the difference was statistically significant( P < 0. 05).Conclusion On the basis of conventional treatment,cefixime is definite in clinical efficacy in treating patients with acute bacterial enteritis,which can effectively improve the symptoms of diarrhea and reduce the level of serum inflammatory factors.
引文
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[12]王川林,刘娇,古雪,等.血清炎症因子水平在血流感染性疾病中的表达及与病原菌、病情程度及预后的相关性研究[J].中国现代医学杂志,2017,27(21):61-65.
[13]薛艳,林黎娟,邵田,等.头孢克肟与头孢克洛治疗急性细菌性肠炎患儿的临床疗效及对TNF-α、IL-8、PCT的影响[J].疑难病杂志,2016,15(11):1174-1177.
[2]张展,吴勇,胡芳琴,等.感染性肠炎的病原学特点与耐药性分析[J].中华医院感染学杂志,2017,27(16):3677-3680.
[3]刘玉敏,杜世超,王海生,等.头孢菌素类抗生素溶剂化物研究进展[J].中国抗生素杂志,2016,41(3):161-165.
[4]李太峰.分析第三代头孢菌素类抗菌药物药理作用及临床合理应用[J].中国实用医药,2017,12(20):194-196.
[5]陈灏珠,林果为.实用内科学[M].北京:人民卫生出版社,2009.
[6]缪晓辉,冉陆,张文宏,等.成人急性感染性腹泻诊疗专家共识[J].中华消化杂志,2013,33(12):793-802.
[7]王建青,刘丽萍,杨琍琦.我院2010-2014年头孢菌素类药物使用分析[J].中国药房,2016,27(5):583-586.
[8]谢玲,翁晓珊,周娜.抗菌类西药的药理药性及合理用药的临床研究[J].海峡药学,2017,29(2):282-283.
[9]尹梅,刘振国,孟静茹,等.口服头孢菌素类药物对肺炎链球菌肺炎大鼠肠道菌群的影响[J].中国医药导报,2015,12(28):9-13.
[10]蔡春燕,庹玉平.不同头孢类抗生素治疗急性细菌性肠炎的疗效及药理分析[J].北方药学,2015,12(1):120-121.
[11]姜云达,岳德永,顾立华,等.头孢克肟治疗急性细菌性肠炎患者临床效果及对血清炎症因子的影响研究[J].国际检验医学杂志,2017,38(23):3225-3227.
[12]王川林,刘娇,古雪,等.血清炎症因子水平在血流感染性疾病中的表达及与病原菌、病情程度及预后的相关性研究[J].中国现代医学杂志,2017,27(21):61-65.
[13]薛艳,林黎娟,邵田,等.头孢克肟与头孢克洛治疗急性细菌性肠炎患儿的临床疗效及对TNF-α、IL-8、PCT的影响[J].疑难病杂志,2016,15(11):1174-1177.