LncRNA与结直肠癌诊断治疗的研究进展
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摘要
结直肠癌(CRC)是常见的恶性肿瘤之一,严重威胁着人类的健康。目前大量的研究表明异常表达的长链非编码RNA(lnc RNA)通过影响肿瘤细胞的增殖、凋亡、迁移及侵袭等生物学行为参与了CRC的发生发展,并且发现lnc RNA的单核苷酸多态性(SNPs)与CRC的易感性密切相关。因此,针对lnc RNA的深入研究有望为CRC的诊断和治疗提供新的手段。
Colorectal cancer(CRC) is one of the most common malignant diseases. At present,studies have indicated that dysregulated long non-coding RNA(lnc RNA) are involved in the tumorigenesis and progression of CRC by affecting on various biological behavior,including the proliferation,apoptosis,migration and invasion of tumor cells. Moreover,emerging evidence has revealed that single nucleotide polymorphisms(SNPs) of lnc RNA are closely related to the susceptibility of CRC. Further study on lnc RNA may provide a new approach for diagnosis and treatment of CRC.
Colorectal cancer(CRC) is one of the most common malignant diseases. At present,studies have indicated that dysregulated long non-coding RNA(lnc RNA) are involved in the tumorigenesis and progression of CRC by affecting on various biological behavior,including the proliferation,apoptosis,migration and invasion of tumor cells. Moreover,emerging evidence has revealed that single nucleotide polymorphisms(SNPs) of lnc RNA are closely related to the susceptibility of CRC. Further study on lnc RNA may provide a new approach for diagnosis and treatment of CRC.
引文
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[28]Li L,Sun R,Liang Y,et al.Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer[J].J Exp Clin Cancer Res,2013,32:104.
[29]Xue Y,Gu D,Ma G,et al.Genetic variants in lnc RNA HOTAIR are associated with risk of colorectal cancer[J].Mutagenesis,2015,30(2):303-310.
[30]Yin DD,Liu ZJ,Zhang E,et al.Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer[J].Tumour Biol,2015,36(6):4851-4859.
[31]Cao X,Zhuang S,Hu Y,et al.Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese[J].Oncotarget,2016,7(14):19054-19059.
[32]Li S,Hua Y,Jin J,et al.Association of genetic variants in lnc RNA H19 with risk of colorectal cancer in a Chinese population[J].Oncotarget,2016,7(18):25470-25477.
[2]Xie X,Tang B,Xiao Y F,et al.Long non-coding RNAs in colorectal cancer[J].Oncotarget,2016,7(5):5226-5239.
[3]Liz J,Esteller M.lnc RNAs and micro RNAs with a role in cancer development[J].Biochim Biophys Acta,2016,1859(1):169-176.
[4]Han D,Wang M,Ma N,et al.Long noncoding RNAs:novel players in colorectal cancer[J].Cancer Lett,2015,361(1):13-21.
[5]Zhao Y,Li H,Fang S,et al.NONCODE 2016:an informative and valuable data source of long non-coding RNAs[J].Nucleic Acids Res,2016,44(D1):D203-D208.
[6]He X,Tan X,Wang X,et al.C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion[J].Tumour Biol,2014,35(12):12181-12188.
[7]Ye Z,Zhou M,Tian B,et al.Expression of lnc RNACCAT1,E-cadherin and N-cadherin in colorectal cancer and its clinical significance[J].Int J Clin Exp Med,2015,8(3):3707-15.
[8]Nissan A,Stojadinovic A,Mitrani-Rosenbaum S,et al.Colon cancer associated transcript-1:a novel RNA expressed in malignant and pre-malignant human tissues[J].Int J Cancer,2012,130(7):1598-606.
[9]Kam Y,Rubinstein A,Naik S,et al.Detection of a long non-coding RNA(CCAT1)in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons[J].Cancer Lett,2014,352(1):90-96.
[10]Hajjari M,Salavaty A.HOTAIR:an oncogenic long noncoding RNA in different cancers[J].Cancer Biol Med,2015,12(1):1-9.
[11]Svoboda M,Slyskova J,Schneiderova M,et al.HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors,but also in the blood of colorectal cancer patients[J].Carcinogenesis,2014,35(7):1510-1515.
[12]Zhao W,Song M,Zhang J,et al.Combined identification of long non-coding RNA CCAT1 and HOTAIR in serum as an effective screening for colorectal carcinoma[J].Int J Clin Exp Pathol,2015,8(11):14131-14140.
[13]Yang L,Qiu M,Xu Y,et al.Upregulation of long noncoding RNA PRNCR1 in colorectal cancer promotes cell proliferation and cell cycle progression[J].Oncol Rep,2016,35(1):318-324.
[14]Ellis BC,Graham LD,Molloy PL.CRNDE,a long noncoding RNA responsive to insulin/IGF signaling,regulates genes involved in central metabolism[J].Biochim Biophys Acta,2014,1843(2):372-386.
[15]Graham LD,Pedersen SK,Brown GS,et al.Colorectal neoplasia differentially expressed(CRNDE),a novel gene with elevated expression in colorectal adenomas and adenocarcinomas[J].Genes Cancer,2011,2(8):829-840.
[16]Liu T,Zhang X,Yang YM,et al.Increased expression of the long noncoding RNA CRNDE-h indicates a poor prognosis in colorectal cancer,and is positively correlated with IRX5 m RNA expression[J].Oncol Targets Ther,2016,9:1437-1448.
[17]Han D,Gao X,Wang M,et al.Long noncoding RNA H19indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to e IF4A3[J].Oncotarget,2016,7(16):22159-22173.
[18]Wang G,Li Z,Zhao Q,et al.Linc RNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/beta-catenin signaling pathway[J].Oncol Rep,2014,31(4):1839-1845.
[19]Wang J,Lei ZJ,Guo Y,et al.mi RNA-regulated delivery of linc RNA-p21 suppresses beta-catenin signaling and tumorigenicity of colorectal cancer stem cells[J].Oncotarget,2015,6(35):37852-37870.
[20]Yoshimoto R,Mayeda A,Yoshida M,et al.MALAT1 long non-coding RNA in cancer[J].Biochim Biophys Acta,2016,1859(1):192-199.
[21]Tang R,Jiang M,Liang L,et al.Long noncoding RNA MALAT-1 can predict poor prognosis:a Meta-analysis[J].Med Sci Monit,2016,22:302-309.
[22]Ji Q,Zhang L,Liu X,et al.Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex[J].Br J Cancer,2014,111(4):736-748.
[23]Yang MH,Hu ZY,Xu C,et al.MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9[J].Biochim Biophys Acta,2015,1852(1):166-174.
[24]Hu ZY,Wang XY,Guo WB,et al.Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells[J].Oncotarget,2016,7(10):11733-11743.
[25]Mccleland ML,Mesh K,Lorenzana E,et al.CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer[J].J Clin Invest,2016,126(2):639-652.
[26]Yang XD,Xu HT,Xu XH,et al.Knockdown of long noncoding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer[J].Oncol Rep,2016,35(1):479-487.
[27]Bian Z,Jin L,Zhang J,et al.Lnc RNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting mi R-204-5p[J].Sci Rep,2016,6:23892.
[28]Li L,Sun R,Liang Y,et al.Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer[J].J Exp Clin Cancer Res,2013,32:104.
[29]Xue Y,Gu D,Ma G,et al.Genetic variants in lnc RNA HOTAIR are associated with risk of colorectal cancer[J].Mutagenesis,2015,30(2):303-310.
[30]Yin DD,Liu ZJ,Zhang E,et al.Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer[J].Tumour Biol,2015,36(6):4851-4859.
[31]Cao X,Zhuang S,Hu Y,et al.Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese[J].Oncotarget,2016,7(14):19054-19059.
[32]Li S,Hua Y,Jin J,et al.Association of genetic variants in lnc RNA H19 with risk of colorectal cancer in a Chinese population[J].Oncotarget,2016,7(18):25470-25477.