骨髓液中微小RNA系列指标表达水平与多发性骨髓瘤病情进展的相关性分析
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摘要
<正>多发性骨髓瘤(multiple myeloma,MM)是指B淋巴细胞发生浆细胞恶性病理改变,以浆细胞出现异常侵袭性增殖,诱发免疫球蛋白出现异常性升高,从而形成单克隆免疫球蛋白为主要临床表现~([1-3])。微小RNA(microRNA,miRNA)属于非编码型小分子RNA的一种。能够经由直接性降解靶基因以及抑制特异性靶基因的转录翻译而发挥控制基因转录的功能。miRNA的过表达可能与MM疾病引发的细胞耐药、异常增殖、凋亡与分化等病理演进过程具有密切关系。部分miRNA已经成为MM靶向治疗的关键性靶点。本研究选取miRNA系列指标中的miRNA-21、miRNA-16、miRNA-15a作为观察指标,
引文
[1]耿传营,陈文明.《中国多发性骨髓瘤诊治指南(2015年修订)》治疗部分解读[J].临床血液学杂志,2016,29(11):923-926.
[2]李兴,马丽娜,彭大为,等.多发性骨髓瘤患者免疫表型及循环血miRNA表达情况研究[J].重庆医学,2017,46(4):534-536.
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[6]李艳杰,李振宇,徐开林.miRNA是多发性骨髓瘤基因治疗潜在的靶标(英文)[J].中国实验血液学杂志,2013,21(5):1318-1325.
[7]Azmi AS,Bao B,Sarkar FH.Exosomes in cancer development,metastasis,and drug resistance:a comprehensive review[J].Cancer Metastasis Rev,2013,32(3-4):623-642.
[8]严笑,张艳丽,欧阳桂芳,等.miRNA-181a对多发性骨髓瘤细胞增殖和迁移的作用[J].中国病理生理杂志,2017,33(1):33-37.
[9]Kouroukis TC,Baldassarre FG,Haynes AE,et al.Bortezomib in multiple myeloma:systematic review and clinical considerations[J].Curr Oncol,2014,21(4):e573-603.
[2]李兴,马丽娜,彭大为,等.多发性骨髓瘤患者免疫表型及循环血miRNA表达情况研究[J].重庆医学,2017,46(4):534-536.
[3]骆小闯,丰茂晓,古春明,等.minRNA-21种子序列反义核酸及抗多发性骨髓瘤应用[J].生命科学研究,2013,17(6):502.
[4]Rajkumar SV,Dimopoulos MA,Palumbo A,et al.International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma[J].Lancet Oncol,2014,15(12):e538-548.
[5]Intermational Myeloma working Group.Criteria for the classifica-tion of monoclonal gammopathies,multiple myeloma and relateddisorders:a report of the International Myeloma Working Group[J].Br J Haematol,2003,121(5):749-957.
[6]李艳杰,李振宇,徐开林.miRNA是多发性骨髓瘤基因治疗潜在的靶标(英文)[J].中国实验血液学杂志,2013,21(5):1318-1325.
[7]Azmi AS,Bao B,Sarkar FH.Exosomes in cancer development,metastasis,and drug resistance:a comprehensive review[J].Cancer Metastasis Rev,2013,32(3-4):623-642.
[8]严笑,张艳丽,欧阳桂芳,等.miRNA-181a对多发性骨髓瘤细胞增殖和迁移的作用[J].中国病理生理杂志,2017,33(1):33-37.
[9]Kouroukis TC,Baldassarre FG,Haynes AE,et al.Bortezomib in multiple myeloma:systematic review and clinical considerations[J].Curr Oncol,2014,21(4):e573-603.