抗癌药物多烯紫杉醇载体
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摘要
多烯紫杉醇(docetaxel)是一种具有良好疗效的抗癌药物,由于其低的水溶性和溶媒所带来的严重副作用,使其临床应用受到限制。基于此问题,通过化学合成的方法,构建抗癌药物多烯紫杉醇载体,一直吸引着科学工作者的广泛关注。本文通过检索近十年来国内外相关文献报道,对多烯紫杉醇载体进行分类,综述其研究进展,并对当前面临的问题进行总结探讨,以期对DTX载体的研发和应用提供参考。
Docetaxel is an effective anticancer drug. Due to its lowwater solubility and serious side effects brought about by solvent used,clinical application of docetaxel is restricted. Based on this problem,Establishing the carriers of docetaxel,an anticancer drug,by means of chemical synthesis has been attracting the attention of scientists. This article reviews the research progress of carriers of docetaxel in the past decade and discusses some problems in the current study,providing reference for the development and utilization of carriers of docetaxel.
Docetaxel is an effective anticancer drug. Due to its lowwater solubility and serious side effects brought about by solvent used,clinical application of docetaxel is restricted. Based on this problem,Establishing the carriers of docetaxel,an anticancer drug,by means of chemical synthesis has been attracting the attention of scientists. This article reviews the research progress of carriers of docetaxel in the past decade and discusses some problems in the current study,providing reference for the development and utilization of carriers of docetaxel.
引文
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