瑞舒伐他汀治疗急性脑梗死146例颈动脉粥样硬化斑块的效果
摘要
目的观察瑞舒伐他汀治疗急性脑梗死患者颈动脉粥样硬化斑块的效果。方法选取2016年9月至2017年9月该院经颈动脉超声检查发现有颈动脉粥样硬化斑块的急性脑梗死患者146例,均予瑞舒伐他汀钙片口服,每日10mg,观察治疗前和治疗6个月后颈动脉粥样硬化斑块面积及血低密度脂蛋白(LDL)水平变化。结果治疗后颈动脉粥样硬化斑块面积由治疗前的(22.5±8.7)mm~2缩小到(10.1±4.4)mm~2;血LDL水平由治疗前的(2.6±0.8)mmol/L下降到治疗后的(1.8±0.6)mmol/L;差异有统计学意义(P<0.01)。治疗6个月后斑块消退38例(26.0%)。两组均未出现不良反应。结论瑞舒伐他汀治疗可有效减小急性脑梗死患者的颈动脉粥样硬化斑块,未见不良反应发生。
引文
[1]陈瑞英,高素玲,郑清存.颈动脉粥样硬化斑块与急性脑梗死患者血脂、血压的相关性研究[J].中国老年学杂志,2011,3(12):2220.
[2]Smith SC Jr,Benjamin EJ,Bonow RO,et al.AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients With Coronary and Other Atherosclerotic Vascular Disease:2011Update:A Guideline From the American Heart Association and American College of Cardiology Foundation[J].J Am Coll Cardiol,2011,58(23):2432.
[3]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国缺血性脑卒中和短暂性脑缺血发作二级预防指南2014[J].中华神经科杂志,2015,48(4):258.
[4]Dormuth CR,Hemmelgam BR,Paterson JM,et al. Use of high potency statins and rates of admission for acute kidney injury:multicenter,retrospective observational analy sis of administra tive databases[J].BMJ,2013(346):f880.
[5]Nakamura H,Arakawa K,Itakura H,et al.Primary prevention of cardiovascular disease with pravas tatin in Japan(MEGA Study):a prospective randomised controlled trial[J].Lancet,2006,368(9542):1155.
[2]Smith SC Jr,Benjamin EJ,Bonow RO,et al.AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients With Coronary and Other Atherosclerotic Vascular Disease:2011Update:A Guideline From the American Heart Association and American College of Cardiology Foundation[J].J Am Coll Cardiol,2011,58(23):2432.
[3]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国缺血性脑卒中和短暂性脑缺血发作二级预防指南2014[J].中华神经科杂志,2015,48(4):258.
[4]Dormuth CR,Hemmelgam BR,Paterson JM,et al. Use of high potency statins and rates of admission for acute kidney injury:multicenter,retrospective observational analy sis of administra tive databases[J].BMJ,2013(346):f880.
[5]Nakamura H,Arakawa K,Itakura H,et al.Primary prevention of cardiovascular disease with pravas tatin in Japan(MEGA Study):a prospective randomised controlled trial[J].Lancet,2006,368(9542):1155.