间皮素对卵巢癌诊断价值的Meta分析
|
摘要
目的:通过Meta分析评估血清间皮素对卵巢癌的诊断价值。方法:全面检索Pub Med、Embase、Web of Science、CBMdisc、万方和中国知网等数据库应用间皮素诊断卵巢癌的文献,采用Rev Man 5.3、Stata 12.0和Meta-disc 1.4等统计软件进行分析。结果:有9篇文献共计1 068例患者纳入本次Meta分析,其中卵巢癌患者451例,非卵巢癌患者617例,合并灵敏度为0.80(95%CI:0.76~0.83),合并特异度为0.81(95%CI:0.78~0.84),合并阳性似然比为6.93(95%CI:3.32~14.46),合并阴性似然比为0.24(95%CI:0.16~0.35),合并诊断比值比为45.69(95%CI:17.49~119.35),SROC曲线下面积为0.90,Q=0.83。结论:血清间皮素对于卵巢癌诊断有较高的敏感度及特异度,与其他肿瘤标志物进行联合检测,可作为临床辅助诊断卵巢癌的有效方法。
Objective:To evaluate the diagnostic value of serum mesothelin level on ovarian cancer. Methods:Relevant studies were identified by systematically searching Pub Med,Embase,Web of Science,CBMdisc,WANFANG,CNKI and so on,articles related to the diagnostic value of serum mesothelin on ovarian cancer were selected. Data analysis was conducted by Rev Man 5.3,Stata 12.0and Meta-Disc1.4. Results:Nine studies with a total of 451 ovarian cancer cases and 617 controls were included. The results of metaanalysis showed that sensitivity and specificity were 0.80(95%CI:0.76~0.83) and 0.81 95%CI:0.78~0.84),respectively;positive likelihood ratio and negative likelihood ratio were 6.93(95%CI:3.32~14.46) and 0.24(95%CI:0.16~0.35),respectively;diagnostic odds ratio was 45.69(95%CI:17.49~119.35);the area under curve of the summary receiver operating characteristic(SROC) was 0.90,Q=0.83.Conclusion:Mesothelin shows a high specificity and a low sensitivity in the diagnosis of ovarian cancer,and it can be used as an effective way for diagnosis of ovarian cancer combined detection with other tumor markers.
Objective:To evaluate the diagnostic value of serum mesothelin level on ovarian cancer. Methods:Relevant studies were identified by systematically searching Pub Med,Embase,Web of Science,CBMdisc,WANFANG,CNKI and so on,articles related to the diagnostic value of serum mesothelin on ovarian cancer were selected. Data analysis was conducted by Rev Man 5.3,Stata 12.0and Meta-Disc1.4. Results:Nine studies with a total of 451 ovarian cancer cases and 617 controls were included. The results of metaanalysis showed that sensitivity and specificity were 0.80(95%CI:0.76~0.83) and 0.81 95%CI:0.78~0.84),respectively;positive likelihood ratio and negative likelihood ratio were 6.93(95%CI:3.32~14.46) and 0.24(95%CI:0.16~0.35),respectively;diagnostic odds ratio was 45.69(95%CI:17.49~119.35);the area under curve of the summary receiver operating characteristic(SROC) was 0.90,Q=0.83.Conclusion:Mesothelin shows a high specificity and a low sensitivity in the diagnosis of ovarian cancer,and it can be used as an effective way for diagnosis of ovarian cancer combined detection with other tumor markers.
引文
[1]Hassan R,Remaley AT,Sampson ML,et al.Detection and quantitation of serum mesothelin,a tumor marker for patients with mesothelioma and ovarian cancer[J].Clin Cancer Res,2006,12(2):447-453
[2]Huang CY,Cheng WF,Lee CN,et al.Serum mesothelin in epithelial ovarian carcinoma:a new screening marker and prognostic factor[J].Anticancer Res,2007,26(6C):4721-4728
[3]冯书君.间皮素在卵巢癌中的研究进展[J].实用妇产科杂志,2013,29(12):900-903
[4]邬兰,张永,曾宪涛.QUADAS-2在诊断准确性研究的质量评价工具中的应用[J].湖北医药学院学报,2013,32(3):201-208
[5]李冬秀,吴小华,刘博君,等.血清间皮素在卵巢上皮性癌诊断和病情监测中的价值[J].中华妇产科杂志,2010,45(4):307-310
[6]刘丽萍,吴小华,梁红霞.卵巢癌患者血清SMRP和HE4的表达及其临床意义[J].中国老年学杂志,2011,31(4):554-557
[7]马娟文,朱天垣,谢秀英.可溶性间皮素相关蛋白和癌抗原125联合检测在卵巢癌诊断中的价值[J].中国医师进修杂志,2011,34(27):50-51
[8]Qiao N,Li H.The value of mesothelin in the diagnosis and follow-up of surgically treated ovarian cancer[J].Eur J Gynaecol Oncol,2013,34(2):163-165
[9]刘畅,王莉.血清间皮素在卵巢上皮性癌诊断中的价值[J].肿瘤研究与临床,2013,25(4):287-288
[10]任玉霞,吴京芳.卵巢癌患者血清可溶性间皮素相关蛋白的检测及其意义[J].中国实验诊断学,2014,18(1):86-89
[11]Ibrahim M,Bahaa A,Ibrahim A,et al.Evaluation of serum mesothelin in malignant and benign ovarian masses[J].Arch Gynecol Obstet,2014,290(1):107-113
[12]毕波,潘逸茹,周慧敏,等.卵巢癌患者血清和肿瘤组织CA125和SMRP表达的临床意义[J].国际检验医学杂志,2015,36(1):22-24
[13]石榴花,任传路,丁磊,等.联合检测血清HE4、SM RP、CEA与CA125在卵巢癌诊断中的应用价值研究[J].检验医学与临床,2016,13(8):1068-1070
[14]李孟达,李志刚.血清CA125,CA199,CA153在卵巢浆,粘液性囊腺癌诊断和动态观察中的价值[J].癌症,1997,16(5):350-352
[15]张淑平,吴梦,柯星,等.卵巢癌患者CD8+T细胞中调节性T细胞相关分子标志物的表达率及临床意义[J].南京医科大学学报(自然科学版),2016,36(4):483-486
[16]李月梅,荆俊鹏,吴蕾,等.SP70在卵巢癌组织中的表达及临床病理意义[J].南京医科大学学报(自然科学版),2016,36(1):65-68
[2]Huang CY,Cheng WF,Lee CN,et al.Serum mesothelin in epithelial ovarian carcinoma:a new screening marker and prognostic factor[J].Anticancer Res,2007,26(6C):4721-4728
[3]冯书君.间皮素在卵巢癌中的研究进展[J].实用妇产科杂志,2013,29(12):900-903
[4]邬兰,张永,曾宪涛.QUADAS-2在诊断准确性研究的质量评价工具中的应用[J].湖北医药学院学报,2013,32(3):201-208
[5]李冬秀,吴小华,刘博君,等.血清间皮素在卵巢上皮性癌诊断和病情监测中的价值[J].中华妇产科杂志,2010,45(4):307-310
[6]刘丽萍,吴小华,梁红霞.卵巢癌患者血清SMRP和HE4的表达及其临床意义[J].中国老年学杂志,2011,31(4):554-557
[7]马娟文,朱天垣,谢秀英.可溶性间皮素相关蛋白和癌抗原125联合检测在卵巢癌诊断中的价值[J].中国医师进修杂志,2011,34(27):50-51
[8]Qiao N,Li H.The value of mesothelin in the diagnosis and follow-up of surgically treated ovarian cancer[J].Eur J Gynaecol Oncol,2013,34(2):163-165
[9]刘畅,王莉.血清间皮素在卵巢上皮性癌诊断中的价值[J].肿瘤研究与临床,2013,25(4):287-288
[10]任玉霞,吴京芳.卵巢癌患者血清可溶性间皮素相关蛋白的检测及其意义[J].中国实验诊断学,2014,18(1):86-89
[11]Ibrahim M,Bahaa A,Ibrahim A,et al.Evaluation of serum mesothelin in malignant and benign ovarian masses[J].Arch Gynecol Obstet,2014,290(1):107-113
[12]毕波,潘逸茹,周慧敏,等.卵巢癌患者血清和肿瘤组织CA125和SMRP表达的临床意义[J].国际检验医学杂志,2015,36(1):22-24
[13]石榴花,任传路,丁磊,等.联合检测血清HE4、SM RP、CEA与CA125在卵巢癌诊断中的应用价值研究[J].检验医学与临床,2016,13(8):1068-1070
[14]李孟达,李志刚.血清CA125,CA199,CA153在卵巢浆,粘液性囊腺癌诊断和动态观察中的价值[J].癌症,1997,16(5):350-352
[15]张淑平,吴梦,柯星,等.卵巢癌患者CD8+T细胞中调节性T细胞相关分子标志物的表达率及临床意义[J].南京医科大学学报(自然科学版),2016,36(4):483-486
[16]李月梅,荆俊鹏,吴蕾,等.SP70在卵巢癌组织中的表达及临床病理意义[J].南京医科大学学报(自然科学版),2016,36(1):65-68