慢性阻塞性肺疾病患者采取抗氧化剂治疗对营养状态、抗氧化指标的影响
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摘要
目的观察慢性阻塞性肺疾病患者采取抗氧化剂治疗对营养状态、抗氧化指标的影响。方法采用随机数字表法将方便选取该院2017年3月—2018年3月收入的110例慢性阻塞性肺疾病患者分为采取常规治疗的对照组及加用抗氧化剂治疗的观察组各55例,对两组营养状态、抗氧化状态、不良反应发生率进行比较。结果治疗后观察组体质量指数(24.91±1.01)kg/m~2、白蛋白(43.25±1.25)g/L、球蛋白(30.30±1.35)g/L、总抗氧化能力(560.89±7.22)μm、血浆还原型谷胱甘肽(1.34±0.21)μm,对照组体质量指数(24.10±1.04)kg/m~2、白蛋白(40.20±1.20)g/L、球蛋白(27.33±1.33)g/L、总抗氧化能力(535.41±7.29)μm、血浆还原型谷胱甘肽(0.98±0.22)μM,两组相比较,观察组均高于对照组,差异有统计学意义(t=0.697、1.021、1.020、1.789、0.691,P<0.05);观察组不良反应发生率9.09%,与对照组不良反应发生率7.27%差异无统计学意义(χ~2=0.221,P>0.05)。结论给予慢性阻塞性肺疾病患者抗氧化剂治疗有助于进一步改善其营养状态和抗氧化指标,值得推广使用。
Objective To observe the effects of antioxidant treatment on nutritional status and antioxidant index in patients with chronic obstructive pulmonary disease. Methods A total of 110 patients with chronic obstructive pulmonary disease who were admitted to our hospital from March 2017 to March 2018 were convenient selected and randomly divided into the control group with conventional treatment and the observation group with antioxidant treatment. The nutritional status, antioxidant status, and incidence of adverse reactions were compared between the two groups. Results After treatment, the body mass index(24.91 ±1.01) kg/m~2, albumin(43.25 ±1.25) g/L, globulin(30.30 ±1.35) g/L, total antioxidant capacity(560.89±7.22)μm, Plasma-reduced glutathione(1.34±0.21)μm, control group body mass index(24.10±1.04) kg/m~2, albumin(40.20 ±1.20) g/L, globulin(27.33 ±1.33) g/L, the total antioxidant capacity(535.41 ±7.29)μm and plasma-reduced glutathione(0.98±0.22)μm were compared between the two groups. The difference was statistically significant(t=0.697, 1.021,1.020, 1.789, 0.691, P<0.05); the incidence of adverse reactions in the observation group was 9.09%, and the incidence of adverse reactions in the control group was 7.27%(χ~2=0.221, P >0.05). Conclusion Antioxidant therapy for patients with chronic obstructive pulmonary disease can further improve their nutritional status and antioxidant index, which is worthy of promotion.
Objective To observe the effects of antioxidant treatment on nutritional status and antioxidant index in patients with chronic obstructive pulmonary disease. Methods A total of 110 patients with chronic obstructive pulmonary disease who were admitted to our hospital from March 2017 to March 2018 were convenient selected and randomly divided into the control group with conventional treatment and the observation group with antioxidant treatment. The nutritional status, antioxidant status, and incidence of adverse reactions were compared between the two groups. Results After treatment, the body mass index(24.91 ±1.01) kg/m~2, albumin(43.25 ±1.25) g/L, globulin(30.30 ±1.35) g/L, total antioxidant capacity(560.89±7.22)μm, Plasma-reduced glutathione(1.34±0.21)μm, control group body mass index(24.10±1.04) kg/m~2, albumin(40.20 ±1.20) g/L, globulin(27.33 ±1.33) g/L, the total antioxidant capacity(535.41 ±7.29)μm and plasma-reduced glutathione(0.98±0.22)μm were compared between the two groups. The difference was statistically significant(t=0.697, 1.021,1.020, 1.789, 0.691, P<0.05); the incidence of adverse reactions in the observation group was 9.09%, and the incidence of adverse reactions in the control group was 7.27%(χ~2=0.221, P >0.05). Conclusion Antioxidant therapy for patients with chronic obstructive pulmonary disease can further improve their nutritional status and antioxidant index, which is worthy of promotion.
引文
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[2]嘉婷,缑剑,翟梅,等.抗氧化剂治疗对慢性阻塞性肺病患者的营养和抗氧化状态的影响[J].临床肺科杂志,2017,22(11):2009-2013.
[3]蒋雪莲,钟萍,黄成亮,等.氧化应激反应标志物在慢性阻塞性肺疾病稳定期患者血清中的表达及意义[J].中国呼吸与危重监护杂志,2016,15(6):542-547.
[4]杜强,朱成华,沈立,等.慢性阻塞性肺疾病患者SIRT1表达与氧化应激的相关性研究[J].临床肺科杂志,2016,21(7):1213-1215.
[5]钟兴峰.维生素C对慢性阻塞性肺疾病急性加重患者氧化应激及肺功能的影响[J].中外医疗,2017,36(6):113-114-117.
[6]陈敏,金志贤,毕虹,等.维生素C在慢阻肺疾病急性加重患者治疗中的研究[J].临床肺科杂志,2016,21(3):456-459.
[7]肖佛义,张庆.N-乙酰半胱氨酸对慢阻肺患者血清CRP、PCT表达及肺功能指标的影响[J].海南医学院学报,2018,24(21):1881-1884.
[8]樊有,顾晓燕,蒋德升,等.噻托溴铵联合N-乙酰半胱氨酸及呼吸训练治疗稳定期中度慢阻肺的临床观察[J].临床肺科杂志,2016,21(3):498-501.