摘要
目的合成三个手性钌配合物Δ-[Ru(bpy)_2(o-tFPIP)](PF_6)_2、Δ-[Ru(bpy)_2(p-tFPIP)](PF_6)_2、Δ-[Ru(bpy)_2(m-tFPIP)](PF_6)_2,研究这些配合物与DNA相互作用。方法用元素分析、质谱和核磁共振对配合物进行表征,并用电子吸收光谱研究钌配合物与DNA相互作用。结果三个手性钌配合物的电子吸收光谱均发生红移和减色效应,其中三氟甲基在对位取代的手性钌配合物减色效应最大。结论这些手性钌配合物通过插入方式与DNA结合,且三氟甲基在不同取代位置会影响配合物与DNA分子相互作用强弱。
Objective To synthesis three chiral ruthenium complexes Δ-[Ru(bpy)_2(o-tFPIP)](PF_6)_2、Δ-[Ru(bpy)_2(p-tFPIP)](PF_6)_2、Δ-[Ru(bpy)_2(m-tFPIP)](PF_6)_2, and study DNA binding properties of these chiral ruthenium complexes. Methods Three chiral ruthenium complexes has been characterized by elemental analysis, ES-MS and 1 HNMR, and the interactions of these complexes with DNA were investigated by electronic absorption spectra. Results The electronic absorption spectra of three chiral ruthenium complexes show red shift and hypochromic effect, of which Δ-[Ru(bpy)_2(p-tFPIP)](PF_6)_2 is the most effective. Conclusion The chiral ruthenium complex binds to DNA through intercalation mode, and the hypochromic effect of chiral ruthenium complexes is different,when these complexes have same substituent but different substitution position.
引文
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