从“三胃火”理论与肠道菌群的相关性探讨藏医防治代谢综合征的机制
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摘要
"三胃火"理论是藏医的核心理论之一,"三胃火"作用于膳食形成"三化味",阐释了食物及药物在人体内部消化、吸收、代谢等过程,其理论贯穿了生理、病理、诊断、治疗等整个藏医学防病养生和疾病诊治过程。"三胃火"紊乱可影响人体的消化、吸收、代谢等生理过程,与代谢综合征及其并发症的发生、发展有密切关系。研究发现,肠道菌群代谢近年来也被认为是人体重要代谢方式,而且肠道菌群的调节对改善代谢综合征及其并发症有着良好的作用。因此文章探讨藏医"三胃火"与肠道菌群的相关性以及两者对代谢综合征发生、发展的影响,结合藏医理论与现代方法,为防治代谢综合征及并发症提供新的思路与方法。
‘Three Gastropyretie' theory is the core of Tibetan medicine theory, acting on dietary form ‘Three After Digestion' and explaining the food and drug in the body internal process such as digestion, absorption, and metabolism. The theory runs through the physiology, pathology, diagnosis, treatment, prevention and management of the whole Tibetan medicine keeping in good health and disease diagnosis and treatment process. The disordering of ‘Three Gastropyretie' can affect the human body's physiological processes such as digestion, absorption and metabolism, which is closely related to the occurrence and development of metabolic syndrome and its complications. It has been found that intestinal flora metabolism has been regarded as an important metabolic mode in recent years, and the regulation of intestinal flora has a good effect on improving metabolic syndrome and its complications. Therefore, this paper researching Tibetan medicine of ‘Three Gastropyretie' and intestinal flora influence on the occurrence and development of metabolic syndrome. Combined with the theory of Tibetan medicine and modern methods,this paper provides a theoretical reference for exploring the combination of Tibetan and Western medicine in the treatment of metabolic syndrome and complications.
‘Three Gastropyretie' theory is the core of Tibetan medicine theory, acting on dietary form ‘Three After Digestion' and explaining the food and drug in the body internal process such as digestion, absorption, and metabolism. The theory runs through the physiology, pathology, diagnosis, treatment, prevention and management of the whole Tibetan medicine keeping in good health and disease diagnosis and treatment process. The disordering of ‘Three Gastropyretie' can affect the human body's physiological processes such as digestion, absorption and metabolism, which is closely related to the occurrence and development of metabolic syndrome and its complications. It has been found that intestinal flora metabolism has been regarded as an important metabolic mode in recent years, and the regulation of intestinal flora has a good effect on improving metabolic syndrome and its complications. Therefore, this paper researching Tibetan medicine of ‘Three Gastropyretie' and intestinal flora influence on the occurrence and development of metabolic syndrome. Combined with the theory of Tibetan medicine and modern methods,this paper provides a theoretical reference for exploring the combination of Tibetan and Western medicine in the treatment of metabolic syndrome and complications.
引文
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[30]东改措.藏医辛味饮食对“普胃酶灼”干预的机理研究.西宁:青海大学,2017
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[34]Claesson M J,Cusack S,O’Sullivan O,et al.Composition,variability,and temporal stability of the intestinal microbiota of theelderly.Proc Natl Acad Sci USA,2011,108:4586-4591
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[36]齐占朋,杨宏艳,王玉春.双歧杆菌的保健作用饥.齐齐哈尔医学院学报,2007,(2)185-187
[37]李森,盛蕾.成年人肥胖及其影响因素的纵向研究.中国体育科技,2014,50(2):71-77
[38]刘道燕,余争平,张刚,等.重庆地区代谢综合征的环境和遗传因素危险性分析.重庆医学,2005,34(1):51-53
[39]Collins S M,Surette M,Bercik P.The interplay between the intestinalmicrobiota and the brain.Nat Rev Microbiol,2012,10(11):735-742
[40]韩蕊,李耘,钱玉英,等.老年代谢综合征患者胰岛素抵抗与认知功能的关系.疑难病杂志,2017,16(5):473-476
[41]胡睿.代谢综合征患者炎性因子与认知功能的关系研究.天津:天津医科大学,2013
[42]陈洁瑜,罗仁,余克强,等.肠道微生物在抑郁症发病中的作用及其研究进展.中华中医药杂志,2017,32(11):5011-5014
[43]文成当智,尕玛措尼,斗周才让,等.藏医五源学说与现代物理学认识物质本质的哲学思考.中华中医药杂志,2017,32(4):1483-1485
[44]Gao F,Li M,Liu Y,et al.Intestinal dysbacteriosis induces changesof T lymphocyte subpopulations in Peyer’s patches of mice andorients the immune response towards humoral immunity.GutPathogens,2012,4(1):19
[2]Borges J B,Barros R T,Carvalho S M,et al.Correlation betweenquality of life,functional class and age in patients with cardiacpacemaker.Rev Bras Cir Cardiovasc,2013,28:47-53
[3]姚东升,刘平,胡义扬,等.中医药治疗代谢综合征研究进展.中华中医药学刊,2013,31(5):1113-1115
[4]李坑,朱光发.肠道菌群与代谢综合征.心肺血管病杂志,2014,33(5):742-744
[5]宇妥·元丹贡布.四部医典.马世林,译.上海:上海科技出版社,1987:10
[6]宇妥·云丹贡布.四部医典(藏文).拉萨:西藏人民出版社,1982
[7]杨晓庆.小鼠肠道菌群代谢产物与糖尿病的相关性研究.乌鲁木齐:新疆医科大学,2010
[8]梁仲惠,梅永红.肠道菌群失调与消化系疾病.华南国防医学杂志,2005,19(3):37-40
[9]邓靖,林亲录,赵谋明.酶法脱除蛋白水解产物苦味的研究进展.中国食品添加剂,2004,157(3):67-72
[10]张丽萍,王康宁.多形拟杆菌与宿主营养物质的利用.中国畜牧杂志,2009,45(9):57-61
[11]Turnbaugh P J,Ley R E,Mahowald M A,et al.An obesity-associatedgut microbiome with increased capacity for energy harvest.Nature,2006,444:1027-1031
[12]王子恺,杨云生,孙刚,等.膳食因素对肠道菌群的影响.中国消化杂志,2017,37(2):137-139
[13]张玲.双歧杆菌作用的研究进展.医学综述,2009,15(17):2556-2559
[14]劳文艳,邱红.双歧杆菌微生态调节作用的应用.中国微生态学杂志,2002,14(5):310-311
[15]张卫.“五味”理论溯源及明以前中药“五味”理论系统之研究.北京:中国中医科学院,2012:2-15
[16]门薇,陈颖,李玉洁,等.肠道菌群对中药有效成分的生物转化研究进展.中国实验方剂学杂志,2015,21(2):229-234
[17]昌迪·班旦措谢.四部医典总论·知识明灯(藏文).北京:民族出版社,2013:113-114
[18]贡主·云登嘉措.临床札记·临床精粹(藏文).北京:民族出版社,2005:223-224
[19]Samuel B S,Gordon J I.A humanized gnotobiot ic mouse model ofhost-archaeal-bact erial mutualism.Proceedings of The NationalAcademy of Science,2006,103:10011-10016
[20]Lederberg J.Infectious history.Science,2000,288:287-293
[21]冯睿章.藏医药治疗2型糖尿病临床疗效研究.成都:成都中医药大学,2012
[22]文成当智.藏药药理数据挖掘方法研究.西宁:青海大学,2016
[23]Guarner F,Malagelada J R.Gut flora in health and disease.Lancet,2003,361(9356):512-516
[24]翟齐啸,田丰伟,王刚,等.肠道微生物与人体健康的研究进展.食品科学,2013,34(15):337-341
[25]Mazmanian S K,Round J L,Kasper D L.A microbial symbiosisfactor prevents intestinal inflammatory disease.Nature,2008,453(7195):620-625
[26]Larsen N,Vogensen F K,Fw V D B,et al.Gut microbiota in humanadults with type 2 diabetes differs from non-diabetic adults.Plos One,2010,5(2):e9085
[27]Campbell T C,Campbell T M.The China study:The mostcomprehensive study of nutrition ever conducted and thestartling implications for diet,weight loss and long-term health.Dallas:Benbella Books,2005
[28]Musso G,Gambino R,Cassader M.Interactions Between GutMicrobiota and Host Metabolism Predisposing to Obesity andDiabetes.Annual Review of Medicine,2012,62(1):361-380
[29]赵立平,张晨虹.肥胖相关的肠道微生物群落结构动力学与功能解析研究.生命科学,2010,22(12):1247-1253
[30]东改措.藏医辛味饮食对“普胃酶灼”干预的机理研究.西宁:青海大学,2017
[31]O’Keefe S J,Greer J B.Microbial induction of immunity,inflammation and cancer.Front Physiol,2011,1:168-169
[32]Ley R E,Turnbaugh P J,Klein S,et al.Microbial ecology:humangut microbes associated with obesity.Nature,2006,444(7122):1022-1023
[33] Rafael Tojo,Adolfo Suárez.Intestinal microbiota in health anddisease:Role of bifidobacteria in gut homeostasis.World Journal ofGastroenterology,2014,20(41):15163-15176
[34]Claesson M J,Cusack S,O’Sullivan O,et al.Composition,variability,and temporal stability of the intestinal microbiota of theelderly.Proc Natl Acad Sci USA,2011,108:4586-4591
[35]Claeason M J,Ian B Jeffery,Susana Conde et al,Gut microbiotacomposition correlates with diet and health in the elderly.Nature,2012,488:178-184
[36]齐占朋,杨宏艳,王玉春.双歧杆菌的保健作用饥.齐齐哈尔医学院学报,2007,(2)185-187
[37]李森,盛蕾.成年人肥胖及其影响因素的纵向研究.中国体育科技,2014,50(2):71-77
[38]刘道燕,余争平,张刚,等.重庆地区代谢综合征的环境和遗传因素危险性分析.重庆医学,2005,34(1):51-53
[39]Collins S M,Surette M,Bercik P.The interplay between the intestinalmicrobiota and the brain.Nat Rev Microbiol,2012,10(11):735-742
[40]韩蕊,李耘,钱玉英,等.老年代谢综合征患者胰岛素抵抗与认知功能的关系.疑难病杂志,2017,16(5):473-476
[41]胡睿.代谢综合征患者炎性因子与认知功能的关系研究.天津:天津医科大学,2013
[42]陈洁瑜,罗仁,余克强,等.肠道微生物在抑郁症发病中的作用及其研究进展.中华中医药杂志,2017,32(11):5011-5014
[43]文成当智,尕玛措尼,斗周才让,等.藏医五源学说与现代物理学认识物质本质的哲学思考.中华中医药杂志,2017,32(4):1483-1485
[44]Gao F,Li M,Liu Y,et al.Intestinal dysbacteriosis induces changesof T lymphocyte subpopulations in Peyer’s patches of mice andorients the immune response towards humoral immunity.GutPathogens,2012,4(1):19