鳖甲煎丸治疗获得性免疫缺陷综合征药物性肝损伤可行性分析
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摘要
获得性免疫缺陷综合征(Acquired immunodeficiency syndrome,AIDS),是感染人类免疫病毒缺陷病毒(Human immunodeficiency virus,HIV)引起的传染性疾病。目前,西药并未有确切有效的治疗HIV/AIDS药物性肝损伤的药物,中医药治疗HIV/AIDS药物性肝损伤具有一定疗效,但缺乏多中心、大数据的中医辨证治疗临床观察研究及从分子生物学角度出发的基础研究~([1])。近年来,随着研究者们对HIV/AIDS药物性肝损伤的关注越来越多,大规模AIDS合并肝损伤的临床实验研究也随之增加,中医药治疗研究有更积极的意义。
Acquired immunodeficiency syndrome(AIDS) is an infectious disease induced by the infection of human immunodeficiency virus(HIV). At present, there is no definitely effective western medicine for liver injury. Chinese medicine has certain curative effect in treating drug-induced liver injury caused by AIDS, while multicenter clinical observation study of Chinese medicine based on syndrome differentiation and treatment with huge data and basic research which starts from the aspect of molecular biology are inadequate. In recent years, with the increasing concern of researchers on drug-induced liver injury caused by AIDS,large-scaled clinical experimental study becomes greater in number, so the treatment of Chinese medicine has more significance in the research.
Acquired immunodeficiency syndrome(AIDS) is an infectious disease induced by the infection of human immunodeficiency virus(HIV). At present, there is no definitely effective western medicine for liver injury. Chinese medicine has certain curative effect in treating drug-induced liver injury caused by AIDS, while multicenter clinical observation study of Chinese medicine based on syndrome differentiation and treatment with huge data and basic research which starts from the aspect of molecular biology are inadequate. In recent years, with the increasing concern of researchers on drug-induced liver injury caused by AIDS,large-scaled clinical experimental study becomes greater in number, so the treatment of Chinese medicine has more significance in the research.
引文
[1]杨君洋,齐唐凯,张仁芳,等.119例艾滋病患者并发药物性肝损伤的临床特点及预后分析[J].临床肝胆杂志,2017,33(8):1537-1542.
[2]中华医学会感染并学会艾滋病学组.艾滋病诊疗指南[J].中华传染病杂志,2006,24(2):133-144.
[3]中华医学会感染病学会艾滋病学组.艾滋病诊疗指南(2011版)[J].中华传染病杂志,2011,29(10):634-635.
[4] Moyle G.Clinical manifestations and management of antiretro-viral nucleoside analog-related mitochondrial toxicity[J].ClinTher,2000,22(8):911-936.
[5]刘靖,王林.抗逆转录病毒药物的肝毒性[J].国外医学:药学分册,2005,32(5):335-336.
[6] Wit FW,Weverling GI,Weel J,et al.Incidence of and riskfactors for severe hepatotoxicity associated with antiretroviralcombination therapy[J].J Infect Dis,2002,86(1):23-31.
[7]王爱霞.HIV/AIDS诊断标准及处理原则[J].中国性病艾滋病防治,1998,4(2):85-87.
[8]汪亚玲,祁燕伟,白劲松,等.AIDS/HIV药物性肝损伤的临床分析[J].昆明医学院学报,2009,30(3):129-132.
[9]李健.抗艾滋病病毒药物的肝损伤[J].胃肠病学和肝病杂志,2008,17(8):616-621.
[10]宋巍.双环醇预防奈韦拉平致艾滋病患者药物性肝损伤的随机对照研究[J].中国实用医药,2014,9(35):110-111.
[11]李燕.双环醇片的药理研究和临床应用[J].传染病信息,2002,15(2):60.
[12]李烨,戴围炜,李燕,等.双环醇对对乙酰氨基酚引起小鼠肝脏能量代谢和线粒体功能障碍的影响[J].药学学报,2001,36(10):723-726.
[13]熊卫标,伍兰萼.中西医结合治疗艾滋病抗病毒治疗后肝损伤疗效观察[J].实用中西医结合临床,2011,11(5):59-60.
[14]邱荃,徐立然,李亮平,等.论肝主疏泄与艾滋病的关系[J].中医杂志,2016,57(15):1271-1274.
[15]沈志平.艾滋病肝细胞的电镜研究[J].日本医学介绍,1988,9(3):142.
[16]李耀烨,文乐敏,杨升.艾滋病肝脾肿大门静脉血流速度与CD4+T淋巴细胞计数相关性的研究[J].中国社区医师,2016,32(27):133-134.
[17] Tshibwabwa ET, Mwaba P, Bogle-Taylor J, et al.Four-year study of abdominal ultrasound in 900 Central Africanadults with AIDS referred for diagnostic imaging[J].AbdomImaging,2000,25(3):290-296.
[18]康文臻,李媛,庄严,等.87例CD4+T淋巴细胞低水平AIDS患者机会性感染临床分析[J].传染病信息,2010,23(6):347-351.
[19]姚光弼.临床肝脏病学[M].2版.上海:上海科教出版社,2011:482-486.
[20] Kerr JF,Wylie AH,Currie AR.Apoptosis:a basic biologi-cal phenomenon with wide-ranging implications in tissue ki-netics[J].Br J Cancer,1972,26(4):239-257.
[21]张国民,王鑫,赵新辉.肝纤维化形成机制的研究进展[J].中国健康月刊,2011,30(8):56-58.
[22]樊尔艳,贺松其,文彬,等.鳖甲煎丸对大鼠肝星状细胞增殖与凋亡的影响[J].中国中西医结合杂志,2016,36(8):8-15.
[23]徐文洋,鲁玉辉,吴若云.虫类药与肝纤维化证治研究[J].光明中医,2016,31(7):1032-1034.
[24]缪京翔.鳖甲煎丸治疗24例乙肝后肝纤维化疗效观察[J].实用中西医结合临床,2010,10(2):29-30.
[25]李学斌.利肝宁对肝纤维化大鼠血清HA、PC-Ⅲ、Ⅳ-C、LN含量的影响[J].中国中医急症, 2003, 12(5):453-454.
[2]中华医学会感染并学会艾滋病学组.艾滋病诊疗指南[J].中华传染病杂志,2006,24(2):133-144.
[3]中华医学会感染病学会艾滋病学组.艾滋病诊疗指南(2011版)[J].中华传染病杂志,2011,29(10):634-635.
[4] Moyle G.Clinical manifestations and management of antiretro-viral nucleoside analog-related mitochondrial toxicity[J].ClinTher,2000,22(8):911-936.
[5]刘靖,王林.抗逆转录病毒药物的肝毒性[J].国外医学:药学分册,2005,32(5):335-336.
[6] Wit FW,Weverling GI,Weel J,et al.Incidence of and riskfactors for severe hepatotoxicity associated with antiretroviralcombination therapy[J].J Infect Dis,2002,86(1):23-31.
[7]王爱霞.HIV/AIDS诊断标准及处理原则[J].中国性病艾滋病防治,1998,4(2):85-87.
[8]汪亚玲,祁燕伟,白劲松,等.AIDS/HIV药物性肝损伤的临床分析[J].昆明医学院学报,2009,30(3):129-132.
[9]李健.抗艾滋病病毒药物的肝损伤[J].胃肠病学和肝病杂志,2008,17(8):616-621.
[10]宋巍.双环醇预防奈韦拉平致艾滋病患者药物性肝损伤的随机对照研究[J].中国实用医药,2014,9(35):110-111.
[11]李燕.双环醇片的药理研究和临床应用[J].传染病信息,2002,15(2):60.
[12]李烨,戴围炜,李燕,等.双环醇对对乙酰氨基酚引起小鼠肝脏能量代谢和线粒体功能障碍的影响[J].药学学报,2001,36(10):723-726.
[13]熊卫标,伍兰萼.中西医结合治疗艾滋病抗病毒治疗后肝损伤疗效观察[J].实用中西医结合临床,2011,11(5):59-60.
[14]邱荃,徐立然,李亮平,等.论肝主疏泄与艾滋病的关系[J].中医杂志,2016,57(15):1271-1274.
[15]沈志平.艾滋病肝细胞的电镜研究[J].日本医学介绍,1988,9(3):142.
[16]李耀烨,文乐敏,杨升.艾滋病肝脾肿大门静脉血流速度与CD4+T淋巴细胞计数相关性的研究[J].中国社区医师,2016,32(27):133-134.
[17] Tshibwabwa ET, Mwaba P, Bogle-Taylor J, et al.Four-year study of abdominal ultrasound in 900 Central Africanadults with AIDS referred for diagnostic imaging[J].AbdomImaging,2000,25(3):290-296.
[18]康文臻,李媛,庄严,等.87例CD4+T淋巴细胞低水平AIDS患者机会性感染临床分析[J].传染病信息,2010,23(6):347-351.
[19]姚光弼.临床肝脏病学[M].2版.上海:上海科教出版社,2011:482-486.
[20] Kerr JF,Wylie AH,Currie AR.Apoptosis:a basic biologi-cal phenomenon with wide-ranging implications in tissue ki-netics[J].Br J Cancer,1972,26(4):239-257.
[21]张国民,王鑫,赵新辉.肝纤维化形成机制的研究进展[J].中国健康月刊,2011,30(8):56-58.
[22]樊尔艳,贺松其,文彬,等.鳖甲煎丸对大鼠肝星状细胞增殖与凋亡的影响[J].中国中西医结合杂志,2016,36(8):8-15.
[23]徐文洋,鲁玉辉,吴若云.虫类药与肝纤维化证治研究[J].光明中医,2016,31(7):1032-1034.
[24]缪京翔.鳖甲煎丸治疗24例乙肝后肝纤维化疗效观察[J].实用中西医结合临床,2010,10(2):29-30.
[25]李学斌.利肝宁对肝纤维化大鼠血清HA、PC-Ⅲ、Ⅳ-C、LN含量的影响[J].中国中医急症, 2003, 12(5):453-454.