人工胃液中药用炭片对尿毒清颗粒的吸附作用研究
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摘要
目的考察人工胃液中药用炭片对常用配伍药物尿毒清颗粒中有效成分芍药苷的吸附作用。方法利用药物溶出度仪模拟人体内环境,将药用炭片和尿毒清颗粒同时加入人工胃液中,用高效液相色谱法测定尿毒清颗粒中有效成分芍药苷的含量,并与尿毒清颗粒单独投入人工胃液中作比较,计算吸附率。结果在人工胃液中,2.0 h内药用炭片对芍药苷的吸附率达92.62%。结论药用炭片在人工胃液中对常用剂量尿毒清颗粒中有效物质芍药苷有强大的吸附作用,服用尿毒清颗粒与药用炭片应间隔2.0 h以上。
Objective To investigate the adsorption effect of medicinal carbon tablets on the effective components( paeoniflorin) of Niaoduqing Granules in artificial gastric juice. Methods The drug solubility meter was used to simulate the internal environment of the human body, and the medicinal carbon tablets and Niaoduqing Granules were added into the artificial gastric juice at the same time.The content of paeoniflorin of Niaoduqing Granules was determined by HPLC and compared with that of Niaoduqing Granules in artificial gastric juice alone, and the adsorption rate was calculated. Results The adsorption rate of medicinal carbon tablets to paeoniflorin was 92. 62% within 2. 0 h in the artificial gastric juice. Conclusion In the artificial gastric juice,the medicinal carbon tablets have powerful adsorption effect on the effective substance paeoniflorin in the common dosage of the Niaoduqing Granules, and the interval time for taking Niaoduqing Granuks and medicinal charcoal tablets should be more than 2. 0 h.
Objective To investigate the adsorption effect of medicinal carbon tablets on the effective components( paeoniflorin) of Niaoduqing Granules in artificial gastric juice. Methods The drug solubility meter was used to simulate the internal environment of the human body, and the medicinal carbon tablets and Niaoduqing Granules were added into the artificial gastric juice at the same time.The content of paeoniflorin of Niaoduqing Granules was determined by HPLC and compared with that of Niaoduqing Granules in artificial gastric juice alone, and the adsorption rate was calculated. Results The adsorption rate of medicinal carbon tablets to paeoniflorin was 92. 62% within 2. 0 h in the artificial gastric juice. Conclusion In the artificial gastric juice,the medicinal carbon tablets have powerful adsorption effect on the effective substance paeoniflorin in the common dosage of the Niaoduqing Granules, and the interval time for taking Niaoduqing Granuks and medicinal charcoal tablets should be more than 2. 0 h.
引文
[1]陈新谦,金有豫,汤光.新编药物学[M].第17版.北京:人民卫生出版社,2011:501.
[2]王玉,王梅,贾强,等.药用炭剂治疗慢性肾功能不全的随机对照多中心临床研究[J].中国临床药理学杂志,2006,22(3):163-166.
[3]杨波,蒋云生,李军,等.爱西特对小分子尿毒素的吸附作用及其影响因素[J].湖南医科大学学报,2003,28(3):285-287.
[4]孙红娟,吴红梅,王锋.药用炭治疗慢性肾脏疾病的系统评价[J].中国循证医学杂志,2009,9(12):1310-1314.
[5]施善芬,黎良达,单爱琴.药用炭治疗高尿酸血症合并慢性肾功能不全患者的临床研究[J].现代实用医学,2013,25(8):865-866.
[6]付国家,郭庆杰.药用活性炭对硫酸奎宁吸附性能的研究[J].青岛科技大学学报,2011,32(6):610-613.
[7]方风琴,李金伟,王迪.药用炭对乳酸左氧氟沙星葡萄糖注射液含量的影响[J].中国新药杂志,2002,11(8):623-624.
[8]朱增燕.蒙脱石对配伍药物体外吸附的影响[J].儿科药学杂志,2005,11(6):28-29.
[9]向国云.蒙脱石散对6种喹诺酮类药物体外吸附的作用分析[J].临床合理用药,2015,8(3A):5-6.
[10]常威.蒙脱石散对部分喹诺酮类药物的体外吸附作用[J].中国医院药学杂志,2004,24(5):268-269.
[11]李刚,吴骏,肖汉扬.蒙脱石散在人工肠液中对盐酸左氧氟沙星片的吸附作用观察[J].江西医药,2005,40(5):260-261.
[12]李晓冰,郭旭东.高效液相色谱法测定尿毒清胶囊中芍药苷的含量[J].黑龙江医药,2002,25(1):13-14.
[13]黄晓玲,朱荃,郑兆广.尿毒清颗粒HPLC指纹图谱研究[J].中国中医药信息杂志,2013,20(6):45-47.
[14]王一,侯连兵.尿毒清片剂质量标准研究[J].中国处方药,2006,52(7):59-61.
[15]沈小莉,黄樱华.尿毒清胶囊的质量控制方法研究[J].海峡药学,2016,28(7):123-124.
[16]国家药典委员会.中华人民共和国药典(四部)[M].北京:中国医药科技出版社,2015:121.
[2]王玉,王梅,贾强,等.药用炭剂治疗慢性肾功能不全的随机对照多中心临床研究[J].中国临床药理学杂志,2006,22(3):163-166.
[3]杨波,蒋云生,李军,等.爱西特对小分子尿毒素的吸附作用及其影响因素[J].湖南医科大学学报,2003,28(3):285-287.
[4]孙红娟,吴红梅,王锋.药用炭治疗慢性肾脏疾病的系统评价[J].中国循证医学杂志,2009,9(12):1310-1314.
[5]施善芬,黎良达,单爱琴.药用炭治疗高尿酸血症合并慢性肾功能不全患者的临床研究[J].现代实用医学,2013,25(8):865-866.
[6]付国家,郭庆杰.药用活性炭对硫酸奎宁吸附性能的研究[J].青岛科技大学学报,2011,32(6):610-613.
[7]方风琴,李金伟,王迪.药用炭对乳酸左氧氟沙星葡萄糖注射液含量的影响[J].中国新药杂志,2002,11(8):623-624.
[8]朱增燕.蒙脱石对配伍药物体外吸附的影响[J].儿科药学杂志,2005,11(6):28-29.
[9]向国云.蒙脱石散对6种喹诺酮类药物体外吸附的作用分析[J].临床合理用药,2015,8(3A):5-6.
[10]常威.蒙脱石散对部分喹诺酮类药物的体外吸附作用[J].中国医院药学杂志,2004,24(5):268-269.
[11]李刚,吴骏,肖汉扬.蒙脱石散在人工肠液中对盐酸左氧氟沙星片的吸附作用观察[J].江西医药,2005,40(5):260-261.
[12]李晓冰,郭旭东.高效液相色谱法测定尿毒清胶囊中芍药苷的含量[J].黑龙江医药,2002,25(1):13-14.
[13]黄晓玲,朱荃,郑兆广.尿毒清颗粒HPLC指纹图谱研究[J].中国中医药信息杂志,2013,20(6):45-47.
[14]王一,侯连兵.尿毒清片剂质量标准研究[J].中国处方药,2006,52(7):59-61.
[15]沈小莉,黄樱华.尿毒清胶囊的质量控制方法研究[J].海峡药学,2016,28(7):123-124.
[16]国家药典委员会.中华人民共和国药典(四部)[M].北京:中国医药科技出版社,2015:121.