灯盏细辛注射液联合神经节苷脂对脑梗死患者神经功能及血液流变学的影响
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摘要
目的探讨灯盏细辛注射液联合神经节苷脂对脑梗死患者神经功能及血液流变学的影响。方法选择2016年10月至2018年6月收治的脑梗死患者104例,按随机双盲法分为两组,各52例。对照组给予神经节苷脂静脉滴注,观察组在此基础上给予灯盏细辛注射液静脉滴注。比较两组患者临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力评分(Barthel)、血液流变学指标及不良反应情况。结果治疗2周后,观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后1个月,两组NIHSS评分较治疗前降低,Barthel评分较治疗前升高,观察组优于对照组,差异有统计学意义(P<0.001);治疗2周后,两组血浆黏度、全血黏度(高切、中切、低切)及红细胞聚集指数均降低,观察组低于对照组,差异有统计学意义(P<0.05);治疗2周期间,观察组不良反应发生率略高于对照组,但差异无统计学意义(P>0.05)。结论灯盏细辛注射液联合神经节苷脂治疗脑梗死可有效提高临床疗效,改善神经功能,提高日常生活能力,降低血液黏稠度,且不增加不良反应,值得临床推广。
Objective To investigate the effect of Dengzhanxixin injection combined with ganglioside on nerve function and hemorheology in patients with cerebral infarction. Methods 104 patients with cerebral infarction admitted to hospital from October 2016 to June 2018 were selected,and they were divided into two groups by randomized double blind method,with 52 cases in each group.Control group were given intravenous drip of ganglioside,and observation group were given intravenous drip of Dengzhanxixin injection on the basis of the control group. And then,clinical efficacy,National Institutes of Health Stroke Scale( NIHSS) scores,daily life ability scores( Barthel),hemorheology indexes and adverse reactions were compared between the two groups.Results After 2 weeks of treatment,the total effective rate of the observation group was higher than that of the control group,difference was statistically significant( P<0.05).After 1 month of treatment,the NIHSS scores of the two groups were lower than those before treatment,and the Barthel indexes of the two groups were higher than those before treatment,and observation group was better than control group,difference was statistically significant( P < 0. 001). After 2 weeks of treatment,plasma viscosity,whole blood viscosity( high shear,middle shear and low shear) and erythrocyte aggregation indexes in the two groups all decreased,and those of the observation group were lower than those of the control group,difference was statistically significant( P<0.05).During 2 weeks of treatment,the incidence of adverse reactions in the observation group was slightly higher than that in the control group,but the difference was not statistically significant( P> 0.05).Conclusion Dengzhanxixin injection combined with ganglioside in the treatment of cerebral infarction can increase clinical efficacy,improve nerve function,enhance daily life ability,reduce blood viscosity,and does not increase adverse reactions,which is worthy of clinical promotion.
Objective To investigate the effect of Dengzhanxixin injection combined with ganglioside on nerve function and hemorheology in patients with cerebral infarction. Methods 104 patients with cerebral infarction admitted to hospital from October 2016 to June 2018 were selected,and they were divided into two groups by randomized double blind method,with 52 cases in each group.Control group were given intravenous drip of ganglioside,and observation group were given intravenous drip of Dengzhanxixin injection on the basis of the control group. And then,clinical efficacy,National Institutes of Health Stroke Scale( NIHSS) scores,daily life ability scores( Barthel),hemorheology indexes and adverse reactions were compared between the two groups.Results After 2 weeks of treatment,the total effective rate of the observation group was higher than that of the control group,difference was statistically significant( P<0.05).After 1 month of treatment,the NIHSS scores of the two groups were lower than those before treatment,and the Barthel indexes of the two groups were higher than those before treatment,and observation group was better than control group,difference was statistically significant( P < 0. 001). After 2 weeks of treatment,plasma viscosity,whole blood viscosity( high shear,middle shear and low shear) and erythrocyte aggregation indexes in the two groups all decreased,and those of the observation group were lower than those of the control group,difference was statistically significant( P<0.05).During 2 weeks of treatment,the incidence of adverse reactions in the observation group was slightly higher than that in the control group,but the difference was not statistically significant( P> 0.05).Conclusion Dengzhanxixin injection combined with ganglioside in the treatment of cerebral infarction can increase clinical efficacy,improve nerve function,enhance daily life ability,reduce blood viscosity,and does not increase adverse reactions,which is worthy of clinical promotion.
引文
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[2]孟学刚,吴波,王明远,等.神经节苷脂辅助治疗脑梗死效果及其对认知功能恢复情况分析[J].解放军医药杂志,2018,30(5):113-116.
[3]张綦慧,张丽,牛焕敏,等.灯盏细辛制剂在脑血管病治疗中的应用[J].吉林中医药,2016,36(9):941-944.
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[8]刘佳,闫建齐.急性脑梗死患者血浆内皮素及血液流变学指标检测分析[J].解放军预防医学杂志,2015,33(2):187-188.
[9]杜衍捷,金醒昉.脑梗死患者神经细胞凋亡研究进展[J].中国老年学杂志,2016,36(14):3600-3602.
[10]王以翠.神经节苷脂对超急性期脑梗死患者脑缺血再灌注损伤的保护作用[J].兰州大学学报(医学版),2015,41(5):17-21.
[11]钟兴继,程静.灯盏细辛对脑梗死患者短期氧化反应、血液流变学及神经功能缺损的影响分析[J].临床和实验医学杂志,2018,17(2):144-147.
[12]梁红霞.灯盏细辛注射液对急性脑梗死患者神经功能状态及脑血流的影响[J].海南医学院学报,2014,20(7):926-929.
[2]孟学刚,吴波,王明远,等.神经节苷脂辅助治疗脑梗死效果及其对认知功能恢复情况分析[J].解放军医药杂志,2018,30(5):113-116.
[3]张綦慧,张丽,牛焕敏,等.灯盏细辛制剂在脑血管病治疗中的应用[J].吉林中医药,2016,36(9):941-944.
[4]中华神经学会,中华神经外科学会.各类脑血管疾病诊断要点(1995)[J].临床和实验医学杂志,2013,12(7):559.
[5]蒋嘉能,刘倩,赵锋.急性脑梗死与NIHSS评分、MRA的相关性研究[J].中国现代医生,2014,52(5):31-32.
[6]陈秀玲,刘明.Barthel指数评定量表在临床康复患者中的应用[J].医药前沿,2016,6(16):100-101.
[7]皮成慧,王君,张荣举,等.颅内侧支循环对急性脑梗死患者预后影响的研究进展[J].中国脑血管病杂志,2018,15(4):212-215.
[8]刘佳,闫建齐.急性脑梗死患者血浆内皮素及血液流变学指标检测分析[J].解放军预防医学杂志,2015,33(2):187-188.
[9]杜衍捷,金醒昉.脑梗死患者神经细胞凋亡研究进展[J].中国老年学杂志,2016,36(14):3600-3602.
[10]王以翠.神经节苷脂对超急性期脑梗死患者脑缺血再灌注损伤的保护作用[J].兰州大学学报(医学版),2015,41(5):17-21.
[11]钟兴继,程静.灯盏细辛对脑梗死患者短期氧化反应、血液流变学及神经功能缺损的影响分析[J].临床和实验医学杂志,2018,17(2):144-147.
[12]梁红霞.灯盏细辛注射液对急性脑梗死患者神经功能状态及脑血流的影响[J].海南医学院学报,2014,20(7):926-929.