放射工作人员淋巴细胞微核异常影响因素的病例对照研究
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摘要
目的探讨广州市放射工作人员淋巴细胞微核异常的发生率及其影响因素。方法采用1∶1配对病例对照研究,将2014年1月1日~12月31日,在某中心进行职业健康检查的1050名放射工作人员中淋巴细胞微核率≥6‰者,共24例作为病例组,按同单位、同性别、年龄相差±5岁进行配对,淋巴细胞微核率正常的放射工作人员,共24例作为对照组。根据《放射工作人员职业健康检查表》收集研究对象的一般基线情况、电离辐射接触情况、混杂因素的接触情况及体检项目指标,使用单因素和多因素条件logistic回归分析方法分析淋巴细胞微核异常的影响因素。结果广州市放射工作人员淋巴细胞微核异常发生率为2.29%,单因素和多因素条件logistic回归有统计学意义的变量为吸烟/被动吸烟情况(OR=3.667)。结论广州市放射工作人员淋巴细胞微核异常情况属正常,其中吸烟/被动吸烟情况是淋巴细胞微核率异常的可能危险因素。
Objective To understand and discuss the incidence and influencing factors of the lymphocyte micronucleus abnormality in the radiation workers in Guangzhou. Methods Using 1: 1 matched case-control study. Case group: from January 1,2014 to December 31,2014,the lymphocyte micronucleus rate is greater than or equal to 6‰ in the 1050 radiation workers who took occupational health examinations in a center,with a total of 24 cases. Control group: 24 cases of radiation workers who had been examined at the same center and were in the same work unit,gender,age difference ± 5 years,and lymphocyte micronucleus rate were normal. According to the occupational health examination form for radiation workers to collect the general baseline,the ionizing radiation exposure,the contact of confounding factors and the physical examination project indicators of research object. And single factor and multifactor conditional logistic regression analysis was respectively used to analyze the influencing factors of the abnormal lymphocyte micronucleus rate. Results The incidence of the lymphocyte micronucleus abnormality of radiation workers in Guangzhou was 2. 29 ﹪. Smoking or passive smoking was the only statistically significant variable( OR = 3. 667). Conclusion The abnormal condition of lymphocyte micronucleus of the radiation workers in Guangzhou is normal,Smoking or passive smoking is the possible risk factor for the exceeded lymphocyte micronucleus rate.
Objective To understand and discuss the incidence and influencing factors of the lymphocyte micronucleus abnormality in the radiation workers in Guangzhou. Methods Using 1: 1 matched case-control study. Case group: from January 1,2014 to December 31,2014,the lymphocyte micronucleus rate is greater than or equal to 6‰ in the 1050 radiation workers who took occupational health examinations in a center,with a total of 24 cases. Control group: 24 cases of radiation workers who had been examined at the same center and were in the same work unit,gender,age difference ± 5 years,and lymphocyte micronucleus rate were normal. According to the occupational health examination form for radiation workers to collect the general baseline,the ionizing radiation exposure,the contact of confounding factors and the physical examination project indicators of research object. And single factor and multifactor conditional logistic regression analysis was respectively used to analyze the influencing factors of the abnormal lymphocyte micronucleus rate. Results The incidence of the lymphocyte micronucleus abnormality of radiation workers in Guangzhou was 2. 29 ﹪. Smoking or passive smoking was the only statistically significant variable( OR = 3. 667). Conclusion The abnormal condition of lymphocyte micronucleus of the radiation workers in Guangzhou is normal,Smoking or passive smoking is the possible risk factor for the exceeded lymphocyte micronucleus rate.
引文
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[11]崔吉茂,冯雷,李尚琴.达州地区258例放射工作人员外周血淋巴细胞微核率分析[J].中国优生与遗传杂志,2016,24(10):63-64.
[2]魏爱丽,孟紫强,牛瑞芳.沙尘暴细颗粒物对人外周血淋巴细胞微核形成的影响[J].环境科学学报,2006,26(3):509-514.
[3]Thierens H,Vral A,De Ridder L.A cytogenetic study of radiological workers:effect of age,smoking and radiation burden on the micronucleus frequency[J].Mutat Res,1996,360(2):75-82.
[4]吴含恬,郭孔荣,方延,等.慢性苯中毒患者脱离苯接触后外周血淋巴细胞微核率与血常规指标变化特征[J].环境与职业医学,2017,34(5):392-397.
[5]Lin D,Guo Y,Yi J,et al.Occupational exposure to formaldehyde and genetic damage in the peripheral blood lymphocytes of plywood workers[J].J Occup Health,2013,55(4):284-291.
[6]周冀武,王学兵,陈军.烹调油烟对职业接触者外周血微核及免疫功能的影响[J].宁夏医科大学学报,2009,31(4):480-481.
[7]中华人民共和国卫生部.WS/T 187-1999淋巴细胞微核估算受照剂量方法[S].北京:中国标准出版社,1999.
[8]牛惠芳,刘静,赵可辉,等.我国放射工作人员外周血淋巴细胞微核检查结果分析[J].中国辐射卫生,2016,25(3):308-310.
[9]胡世杰,黄伟旭,杨浩贤,等.广东省介入放射工作人员健康状况调查分析[J].中国辐射卫生,2011,20(1):65-67.
[10]董雪梅,陈松银,黄流宽,等.低剂量电离辐射对放射工作人员血像和淋巴细胞微核的影响[J].中国辐射卫生,2012,21(2):185-186.
[11]崔吉茂,冯雷,李尚琴.达州地区258例放射工作人员外周血淋巴细胞微核率分析[J].中国优生与遗传杂志,2016,24(10):63-64.