摘要
从香蕉树皮中提取香蕉纤维素微晶,将甲钴胺、香蕉纤维素微晶和乳酸-羟基乙酸共聚物(PLGA)制备成载甲钴胺香蕉纤维素微晶/PLGA介孔材料。运用SEM、BET、TG-MS和FTIR对产物进行了表征;采用紫外分光光度计对载甲钴胺介孔材料进行了载药率、包封率、体外释放度测定。红外谱图分析表明,所制备的香蕉纤维素微晶的主要成分为纤维素;BET法测定结果表明,载甲钴胺香蕉纤维素微晶/PLGA介孔材料的平均孔径(4V/A)(V为孔体积,A为表面积)为17.89 nm;TG-MS结果表明,载甲钴胺香蕉纤维素微晶/PLGA介孔材料分解温度约为300℃;体外释放实验表明,该材料对甲钴胺有较好的控释作用,药物释放遵循零级释放动力学方程。
A mesoporous material loading mecobalamin was prepared using mecobalamin, banana microcrystalline cellulose extracted from banana fiber and poly(lactic-co-glycolic acid) PLGA. The products were characterized by SEM, specific surface area and pore size analysis(BET), thermogravimetric analysis-mass spectrometry(TG-MS) and FTIR. The drug loading content,encapsulation efficiency, and in vitro release rate of mesoporous material loading mecobalamin were studied by UV spectrophotometry.FTIR analysis showed that the main component of the prepared banana microcrystalline cellulose was cellulose. The BET results showed that the average pore diameter〔4 V(pore volume)/A(surface area)〕of banana microcrystalline cellulose/PLGA mesoporous material loading mecobalamin was 17.89 nm. TG-MS results demonstrated that the decomposition temperature of the mesoporous material loading mecobalamin was about 300 ℃. In addition, the material had a great controlled release for mecobalamin and the drug release followed the zero-order release kinetics.
引文
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