牙菌斑生物膜研究模型的进展
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摘要
口腔微生物群落是典型的生物膜,牙菌斑生物膜是多种菌属组成的三维结构,黏附在牙齿表面,具有生物膜结构和微生物生理学的功能。牙菌斑生物膜是龋病和牙周病的主要致病因素,已有多种生物膜模型用于研究龋病的病因、预防和治疗的研究。这些龋病生物膜模型有助于研究者用一种可控、简化的方式来预测龋病的临床进展结果。目前,研究龋病微生物的模型有体外单菌种生物膜模型和多菌种生物膜模型。本文将从研究龋病的生物膜体外模型建立做一综述。
Oral microbial community is a typical biofilm. The dental plaque biofilm possess a threedimensional structure,which is composed of various bacteria and adheres to the surface of the teeth. It has the function of biofilm structure and microbial physiology. Dental plaque biofilm is one of key etiological factors of dental caries and periodontal diseases. A various models have been developed to study the mechanisms and courses of their formation as well as the etiology,prevention and treatment of dental caries. These carious biofilm models help researchers predict the clinical outcome of caries in a controlled and simplified manner. At present,the models for studying caries include single-species biofilm models and multispecies biofilm models in vitro. This review was presented the research progress on establish models of biofilm of dental caries.
Oral microbial community is a typical biofilm. The dental plaque biofilm possess a threedimensional structure,which is composed of various bacteria and adheres to the surface of the teeth. It has the function of biofilm structure and microbial physiology. Dental plaque biofilm is one of key etiological factors of dental caries and periodontal diseases. A various models have been developed to study the mechanisms and courses of their formation as well as the etiology,prevention and treatment of dental caries. These carious biofilm models help researchers predict the clinical outcome of caries in a controlled and simplified manner. At present,the models for studying caries include single-species biofilm models and multispecies biofilm models in vitro. This review was presented the research progress on establish models of biofilm of dental caries.
引文
[1]周学东,施文元.人体口腔微生物组群与牙菌斑生物膜[J].华西口腔医学杂志,2010,28(2):115-118.
[2]Santin GC,Oliveira DS,Galo R,et al.Antimicrobial photodynamic therapy and dental plaque:a systematic review of the literature[J].Scientific World Journal,2014(2014):824538.
[3]Samaranayake L,Matsubara VH.Normal Oral Flora and the Oral Ecosystem[J].Dent Clin North Am,2017,61(2):199-215.
[4]Sampaio-Maia B,Caldas IM,Pereira ML,et al.The Oral Microbiome in Health and Its Implication in Oral and Systemic Diseases[J].Adv Appl Microbiol,2016(97):171-210.
[5]周学东,徐健,施文元.人类口腔微生物组学研究:现状、挑战及机遇[J].微生物学报,2017,57(6):806-821.
[6]凌均棨.牙菌斑生物膜的研究进展[J/CD].中华口腔医学研究杂志(电子版),2008,2(2):103-108.
[7]黎卫兰,徐琼.粪肠球菌生物膜细胞外聚合物的研究进展[J].国际口腔医学杂志,2011,38(4):426-429.
[8]Zhou H,Liu H,Weir MD,et al.Three-dimensional biofilm properties on dental bonding agent with varying quaternary ammonium charge densities[J].J Dent,2016(53):73-81.
[9]董维理,周影虹,李成章,等.自然牙菌斑生物膜模型的构建及应用[J].上海口腔医学,2010,19(2):196-201.
[10]Bourgeois D,David A,Inquimbert C,et al.Quantification of carious pathogens in the interdental microbiota of young cariesfree adults[J].PLo S One,2017,12(10):e0185804.
[11]Wake N,Asahi Y,Noiri Y,et al.Temporal dynamics of bacterial microbiota in the human oral cavity determined using an in situ model of dental biofilms[J].NPJ Biofilms Microbiomes,2016(2):16018.
[12]Salli KM,Ouwehand AC.The use of in vitro model systems to study dental biofilms associated with caries:a short review[J].J Oral Microbiol,2015(7):26149.
[13]Liu Y,Ren Z,Hwang G,et al.Therapeutic Strategies Targeting Cariogenic Biofilm Microenvironment[J].Adv Dent Res,2018,29(1):86-92.
[14]Zhan L.Rebalancing the Caries Microbiome Dysbiosis:Targeted Treatment and Sugar Alcohols[J].Adv Dent Res,2018,29(1):110-116.
[15]Saputo S,Faustoferri RC,Quivey RG Jr.A drug repositioning approach reveals Streptococcus mutans is susceptible to a diverse range of established antimicrobials and nonantibiotics[J].Antimicrob Agents Chemother,2017,62(1).pii:e01674-17.
[16]Liu J,Ling JQ,Zhang K,et al.Effect of sodium fluoride,ampicillin,and chlorhexidine on Streptococcus mutans biofilm detachment[J].Antimicrob Agents Chemother,2012,56(8):4532-4535.
[17]Ferrazzano GF,Scioscia E,Sateriale D,et al.In Vitro Antibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria[J].Biomed Res Int,2017(2017):2152749.
[18]Salli KM,Gursoy UK,S?derling EM,et al.Effects of Xylitol and Sucrose Mint Products on Streptococcus mutans Colonization in a Dental Simulator Model[J].Curr Microbiol,2017,74(10):1153-1159.
[19]Mira A.Oral Microbiome Studies:Potential Diagnostic and Therapeutic Implications[J].Adv Dent Res,2018,29(1):71-77.
[20]Filoche SK,Anderson SA,Sissons CH.Biofilm growth of Lactobacillus species is promoted by Actinomyces species and Streptococcus mutans[J].Oral Microbiol Immunol,2004,19(5):322-326.
[21]Cavalcanti YW,Bertolini MM,da Silva WJ,et al.A threespecies biofilm model for the evaluation of enamel and dentin demineralization[J].Biofouling,2014,30(5):579-588.
[22]Zhang K,Wang S,Zhou X,et al.Effect of antibacterial dental adhesive on multispecies biofilms formation[J].J Dent Res,2015,94(4):622-629.
[23]Kim D,Hwang G,Liu Y,et al.Cranberry Flavonoids Modulate Cariogenic Properties of Mixed-Species Biofilm through Exopolysaccharides-Matrix Disruption[J].PLo S One,2015,10(12):e0145844.
[24]Han Q,Li B,Zhou X,et al.Anti-Caries Effects of Dental Adhesives Containing Quaternary Ammonium Methacrylates with Different Chain Lengths[J].Materials(Basel),2017,10(6).pii:E643.
[25]Ge Y,Ren B,Zhou X,et al.Novel Dental Adhesive with BiofilmRegulating and Remineralization Capabilities[J].Materials(Basel),2017,10(1).pii:E26.
[26]Arthur RA,Waeiss RA,Hara AT,et al.A defined-multispecies microbial model for studying enamel caries development[J].Caries Res,2013,47(4):318-324.
[27]Gabrilska RA,Rumbaugh KP.Biofilm models of polymicrobial infection[J].Future Microbiol,2015,10(12):1997-2015.
[28]鲁纯,陈武,刘来奎.牙菌斑生物膜模型的研究进展[J].国际口腔医学杂志,2009,36(4):469-471.
[29]Schlafer S,Raarup MK,Meyer RL,et al.p H landscapes in a novel five-species model of early dental biofilm[J].PLo S one,2011,6(9):e25299.
[30]Blanc V,Isabal S,Sánchez MC,et al.Characterization and application of a flow system for in vitro multispecies oral biofilm formation[J].J Periodontal Res,2014,49(3):323-332.
[31]Marsh PD.In Sickness and in Health-What Does the Oral Microbiome Mean to Us?An Ecological Perspective[J].Adv Dent Res,2018,29(1):60-65.
[32]Darrene LN,Cecile B.Experimental Models of Oral Biofilms Developed on Inert Substrates:A Review of the Literature[J].Biomed Res Int,2016(2016):7461047.
[2]Santin GC,Oliveira DS,Galo R,et al.Antimicrobial photodynamic therapy and dental plaque:a systematic review of the literature[J].Scientific World Journal,2014(2014):824538.
[3]Samaranayake L,Matsubara VH.Normal Oral Flora and the Oral Ecosystem[J].Dent Clin North Am,2017,61(2):199-215.
[4]Sampaio-Maia B,Caldas IM,Pereira ML,et al.The Oral Microbiome in Health and Its Implication in Oral and Systemic Diseases[J].Adv Appl Microbiol,2016(97):171-210.
[5]周学东,徐健,施文元.人类口腔微生物组学研究:现状、挑战及机遇[J].微生物学报,2017,57(6):806-821.
[6]凌均棨.牙菌斑生物膜的研究进展[J/CD].中华口腔医学研究杂志(电子版),2008,2(2):103-108.
[7]黎卫兰,徐琼.粪肠球菌生物膜细胞外聚合物的研究进展[J].国际口腔医学杂志,2011,38(4):426-429.
[8]Zhou H,Liu H,Weir MD,et al.Three-dimensional biofilm properties on dental bonding agent with varying quaternary ammonium charge densities[J].J Dent,2016(53):73-81.
[9]董维理,周影虹,李成章,等.自然牙菌斑生物膜模型的构建及应用[J].上海口腔医学,2010,19(2):196-201.
[10]Bourgeois D,David A,Inquimbert C,et al.Quantification of carious pathogens in the interdental microbiota of young cariesfree adults[J].PLo S One,2017,12(10):e0185804.
[11]Wake N,Asahi Y,Noiri Y,et al.Temporal dynamics of bacterial microbiota in the human oral cavity determined using an in situ model of dental biofilms[J].NPJ Biofilms Microbiomes,2016(2):16018.
[12]Salli KM,Ouwehand AC.The use of in vitro model systems to study dental biofilms associated with caries:a short review[J].J Oral Microbiol,2015(7):26149.
[13]Liu Y,Ren Z,Hwang G,et al.Therapeutic Strategies Targeting Cariogenic Biofilm Microenvironment[J].Adv Dent Res,2018,29(1):86-92.
[14]Zhan L.Rebalancing the Caries Microbiome Dysbiosis:Targeted Treatment and Sugar Alcohols[J].Adv Dent Res,2018,29(1):110-116.
[15]Saputo S,Faustoferri RC,Quivey RG Jr.A drug repositioning approach reveals Streptococcus mutans is susceptible to a diverse range of established antimicrobials and nonantibiotics[J].Antimicrob Agents Chemother,2017,62(1).pii:e01674-17.
[16]Liu J,Ling JQ,Zhang K,et al.Effect of sodium fluoride,ampicillin,and chlorhexidine on Streptococcus mutans biofilm detachment[J].Antimicrob Agents Chemother,2012,56(8):4532-4535.
[17]Ferrazzano GF,Scioscia E,Sateriale D,et al.In Vitro Antibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria[J].Biomed Res Int,2017(2017):2152749.
[18]Salli KM,Gursoy UK,S?derling EM,et al.Effects of Xylitol and Sucrose Mint Products on Streptococcus mutans Colonization in a Dental Simulator Model[J].Curr Microbiol,2017,74(10):1153-1159.
[19]Mira A.Oral Microbiome Studies:Potential Diagnostic and Therapeutic Implications[J].Adv Dent Res,2018,29(1):71-77.
[20]Filoche SK,Anderson SA,Sissons CH.Biofilm growth of Lactobacillus species is promoted by Actinomyces species and Streptococcus mutans[J].Oral Microbiol Immunol,2004,19(5):322-326.
[21]Cavalcanti YW,Bertolini MM,da Silva WJ,et al.A threespecies biofilm model for the evaluation of enamel and dentin demineralization[J].Biofouling,2014,30(5):579-588.
[22]Zhang K,Wang S,Zhou X,et al.Effect of antibacterial dental adhesive on multispecies biofilms formation[J].J Dent Res,2015,94(4):622-629.
[23]Kim D,Hwang G,Liu Y,et al.Cranberry Flavonoids Modulate Cariogenic Properties of Mixed-Species Biofilm through Exopolysaccharides-Matrix Disruption[J].PLo S One,2015,10(12):e0145844.
[24]Han Q,Li B,Zhou X,et al.Anti-Caries Effects of Dental Adhesives Containing Quaternary Ammonium Methacrylates with Different Chain Lengths[J].Materials(Basel),2017,10(6).pii:E643.
[25]Ge Y,Ren B,Zhou X,et al.Novel Dental Adhesive with BiofilmRegulating and Remineralization Capabilities[J].Materials(Basel),2017,10(1).pii:E26.
[26]Arthur RA,Waeiss RA,Hara AT,et al.A defined-multispecies microbial model for studying enamel caries development[J].Caries Res,2013,47(4):318-324.
[27]Gabrilska RA,Rumbaugh KP.Biofilm models of polymicrobial infection[J].Future Microbiol,2015,10(12):1997-2015.
[28]鲁纯,陈武,刘来奎.牙菌斑生物膜模型的研究进展[J].国际口腔医学杂志,2009,36(4):469-471.
[29]Schlafer S,Raarup MK,Meyer RL,et al.p H landscapes in a novel five-species model of early dental biofilm[J].PLo S one,2011,6(9):e25299.
[30]Blanc V,Isabal S,Sánchez MC,et al.Characterization and application of a flow system for in vitro multispecies oral biofilm formation[J].J Periodontal Res,2014,49(3):323-332.
[31]Marsh PD.In Sickness and in Health-What Does the Oral Microbiome Mean to Us?An Ecological Perspective[J].Adv Dent Res,2018,29(1):60-65.
[32]Darrene LN,Cecile B.Experimental Models of Oral Biofilms Developed on Inert Substrates:A Review of the Literature[J].Biomed Res Int,2016(2016):7461047.