低频超声对牙菌斑生物膜促渗作用的研究进展
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摘要
牙菌斑生物膜是一种细菌性生物膜,为基质包裹的互相粘附,或粘附于牙面、牙间或修复体表面的软而未矿化的细菌性群体,不能被水冲去或漱掉。它是一个具有结构、形态和代谢活动的独立微生态环境,其耐药性是浮游生物的许多倍。研究人员发现,低频率超声可以提高药物在生物膜中的渗透效应,从而更好地发挥杀菌作用。具有很好的临床应用前景。该文对低频超声对牙菌斑生物膜促渗作用的研究进展作一综述。
A plaque biofilm is a bacterial biofilm,which is a soft,unmineralized bacterial population encased in a matrix that adheres to each other,or adheres to the surfaces of teeth,interdentals or prostheses and can not be washed away by water. It is an independent micro-ecological environment with structural,morphological,and metabolic activities,and its resistance is many times that of plankton. The researchers found that low-frequency ultrasound can improve the penetration of drugs in biofilms,so as to better play a bactericidal effect. It has a good clinical application prospects. This article reviews the research progress of low-frequency ultrasound on the permeation of dental plaque.
A plaque biofilm is a bacterial biofilm,which is a soft,unmineralized bacterial population encased in a matrix that adheres to each other,or adheres to the surfaces of teeth,interdentals or prostheses and can not be washed away by water. It is an independent micro-ecological environment with structural,morphological,and metabolic activities,and its resistance is many times that of plankton. The researchers found that low-frequency ultrasound can improve the penetration of drugs in biofilms,so as to better play a bactericidal effect. It has a good clinical application prospects. This article reviews the research progress of low-frequency ultrasound on the permeation of dental plaque.
引文
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[3]周东学,施文元.微生物生物膜与感染[M].北京:人民卫生出版社,2012:4.
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[12] Xiong F,Nirupama S,Sirsi SR,et al. Ultrasound-stimulated drug delivery using therapeutic reconstituted high-density lipoprotein nanoparticles[J]. Nanotheranostics,2017,1(4):440.
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[14]陈磊.低频超声透皮给药的作用机制和影响因素[J].科技视界,2016(17):241-241.
[15] Hsiao PF,Peng S,Tang TC,et al. Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol)and its oleylamine conjugate[J]. Int J Nanomed,2016,11:1867
[16] Hersh DS,Nguyen BA,Dancy JG,et al. Pulsed ultrasound expands the extracellular and perivascular spaces of the brain[J].Brain Research,2016,1646:543-550.
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[18] Pereira TA,Ramos DN,Lopez RFV. Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment[J].Sci Rep,2017,7:44236.
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[22] Costerton JW,Stewart PS,Greenberg EP. Bacterial biofilms:a common cause of persistent infections[J]. Science,1999,284(5418):1318-1322.
[23] Yu OY,Zhao IS,Mei ML,et al. Dental biofilm and laboratory microbial culture models for cariology research[J]. Dent J,2017,5(2):21.
[24]蒋治楠,王涛,汪滢,等.低频超声对金黄色葡萄球菌生物膜的促渗作用研究[J].现代生物医学进展,2016,16(14):2618-2623.
[25] Shi M,Chen L,Wang Y,et al. Effect of low-frequency pulsed ultrasound on drug delivery,antibacterial efficacy,and bone cement degradation in vancomycin-loaded calcium phosphate cement[J].Med Sci Monit,2018,24:797-802.
[26]徐杰,庄万强,斯海波,等.低频超声联合抗生素对表皮葡萄球菌生物膜渗透性的影响[J].中国抗生素杂志,2014,5(39):390-393.
[27] Gomes LC,Mergulh2o FJ. SEM analysis of surface impact on biofilm antibiotic treatment[J]. Scanning,2017,2017(1):1-7.
[28] Zhang B,Chen M,Zhang Y,et al. An ultrasonic nanobubble-mediated PNP/fludarabine suicide gene system:A new approach for the treatment of hepatocellular carcinoma[J]. PLoS One,2018,13(5):e0196686.
[29]朱晨,方诗元,孔荣,等.超声靶向微泡破坏增强人β-防御素3抑制小鼠体内耐药葡萄球菌生物膜形成[J].生物骨科材料与临床研究,2015,12(5):8-12.
[30] Li F,Wu W,Xiang L,et al. Sustained release of VH and rh BMP-2 from nanoporous magnesium-zinc-silicon xerogels for osteomyelitis treatment and bone repair[J]. Int J Nanomedicine,2015,22(10):4071-4080.
[31] Kluin OS,Busscher HJ,Neut D,et al. Poly(trimethylene carbonate)as a carrier for rifampicin and vancomycin to target therapy‐recalcitrant staphylococcal biofilms[J]. J Orthop Res,2016,34(10):1828-1837.
[32] Lattwein KR,Shekhar H,Wjb VW,et al. An in vitro proof-ofprinciple study of sonobactericide[J]. Sci Repuk, 2018,8(1):3411.
[33]江和逊.低频低强度超声联合抗生素对ESBLs大肠杆菌的协同增效作用研究[D].重庆:重庆医科大学,2016.
[34]刘立婷,余加林,郜向娜,等.低频超声联合环丙沙星对铜绿假单胞菌生物被膜的杀菌作用及其结构的影响[J].中国超声医学杂志,2011,27(7):577-580.
[35]叶银存,余加林,刘立婷,等.低频超声联合盐酸氨溴索对表皮葡萄球菌生物被膜的影响[J].中国超声医学杂志,2012,28(7):581-584.
[2]曹采方.临床牙周病学[M].北京:北京大学医学出版社,2008:1.
[3]周东学,施文元.微生物生物膜与感染[M].北京:人民卫生出版社,2012:4.
[4] Akram Z,Alshareef SA,Daood U,et al. Bactericidal efficacy of photodynamic therapy against periodontal pathogens in periodontal disease:A systematic review[J]. Photomed Laser Surg,2016,34(4):137-149.
[5]王月萍,毕良佳.光动力与声动力疗法杀伤肿瘤细胞的研究进展[J].医学综述,2016,22(9):1691-1693.
[6] Serpe L,Giuntini F. Sonodynamic antimicrobial chemotherapy:First steps towards a sound approach for microbe inactivation[J]. J Photoch Photobio B,2015,150:44-49.
[7] Wu X,Joyce EM,Mason TJ. Evaluation of the mechanisms of the effect of ultrasound on Microcystis aeruginosa, at different ultrasonic frequencies[J]. Water Res,2012,46(9):2851.
[8]赵严礼,吕茉扬,毛立民.血卟啉单甲醚荧光光谱对口腔黏膜癌的特异性诊断[J].现代口腔医学杂志,2016,30(2):102-104.
[9]孔杰,温见燕,张建彬,等.低频超声经皮给药治疗进展[J].中华医学超声杂志(电子版),2016,13(1):8-12.
[10] Pereira TA,Ramos DN,Lopez RFV. Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment[J]. Sci Rep,2017,7:44236.
[11] Shen ZY,Liu C,Wu MF,et al. Spiral computed tomography evaluation of rabbit VX2 hepatic tumors treated with 20 kHz ultrasound and microbubbles[J]. Oncology Letters,2017,14(3):3124.
[12] Xiong F,Nirupama S,Sirsi SR,et al. Ultrasound-stimulated drug delivery using therapeutic reconstituted high-density lipoprotein nanoparticles[J]. Nanotheranostics,2017,1(4):440.
[13] Zhao D,Meng T,Yang J,et al. Hemostatic mechanism underlying microbubble-enhanced non-focused ultrasound in the treatment of a rabbit liver trauma model[J]. Exp BiolL Med,2017,242(2):231.
[14]陈磊.低频超声透皮给药的作用机制和影响因素[J].科技视界,2016(17):241-241.
[15] Hsiao PF,Peng S,Tang TC,et al. Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol)and its oleylamine conjugate[J]. Int J Nanomed,2016,11:1867
[16] Hersh DS,Nguyen BA,Dancy JG,et al. Pulsed ultrasound expands the extracellular and perivascular spaces of the brain[J].Brain Research,2016,1646:543-550.
[17] Wang P,Xing R,Wu Y,et al. Effect of ultrasound-enhanced transdermal drug delivery efficiency of nanoparticles and brucine[J].Biomed Res Int,2017(3):1-8.
[18] Pereira TA,Ramos DN,Lopez RFV. Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment[J].Sci Rep,2017,7:44236.
[19] Jabbari N,Asghari MH,Ahmadian H,et al. Developing a commercial air ultrasonic ceramic transducer to transdermal insulin delivery[J].J Med Signals Sens,2015,5(2):117.
[20] Yang R,Wei T,Goldberg H,et al.Getting drugs across biological barriers[J].Adv Mater,2017,29(37):1606596.
[21] Simonin JP. On the mechanisms of in vitro and in vivo phonophoresis[J].J Control Release,1995,33(1):125-141.
[22] Costerton JW,Stewart PS,Greenberg EP. Bacterial biofilms:a common cause of persistent infections[J]. Science,1999,284(5418):1318-1322.
[23] Yu OY,Zhao IS,Mei ML,et al. Dental biofilm and laboratory microbial culture models for cariology research[J]. Dent J,2017,5(2):21.
[24]蒋治楠,王涛,汪滢,等.低频超声对金黄色葡萄球菌生物膜的促渗作用研究[J].现代生物医学进展,2016,16(14):2618-2623.
[25] Shi M,Chen L,Wang Y,et al. Effect of low-frequency pulsed ultrasound on drug delivery,antibacterial efficacy,and bone cement degradation in vancomycin-loaded calcium phosphate cement[J].Med Sci Monit,2018,24:797-802.
[26]徐杰,庄万强,斯海波,等.低频超声联合抗生素对表皮葡萄球菌生物膜渗透性的影响[J].中国抗生素杂志,2014,5(39):390-393.
[27] Gomes LC,Mergulh2o FJ. SEM analysis of surface impact on biofilm antibiotic treatment[J]. Scanning,2017,2017(1):1-7.
[28] Zhang B,Chen M,Zhang Y,et al. An ultrasonic nanobubble-mediated PNP/fludarabine suicide gene system:A new approach for the treatment of hepatocellular carcinoma[J]. PLoS One,2018,13(5):e0196686.
[29]朱晨,方诗元,孔荣,等.超声靶向微泡破坏增强人β-防御素3抑制小鼠体内耐药葡萄球菌生物膜形成[J].生物骨科材料与临床研究,2015,12(5):8-12.
[30] Li F,Wu W,Xiang L,et al. Sustained release of VH and rh BMP-2 from nanoporous magnesium-zinc-silicon xerogels for osteomyelitis treatment and bone repair[J]. Int J Nanomedicine,2015,22(10):4071-4080.
[31] Kluin OS,Busscher HJ,Neut D,et al. Poly(trimethylene carbonate)as a carrier for rifampicin and vancomycin to target therapy‐recalcitrant staphylococcal biofilms[J]. J Orthop Res,2016,34(10):1828-1837.
[32] Lattwein KR,Shekhar H,Wjb VW,et al. An in vitro proof-ofprinciple study of sonobactericide[J]. Sci Repuk, 2018,8(1):3411.
[33]江和逊.低频低强度超声联合抗生素对ESBLs大肠杆菌的协同增效作用研究[D].重庆:重庆医科大学,2016.
[34]刘立婷,余加林,郜向娜,等.低频超声联合环丙沙星对铜绿假单胞菌生物被膜的杀菌作用及其结构的影响[J].中国超声医学杂志,2011,27(7):577-580.
[35]叶银存,余加林,刘立婷,等.低频超声联合盐酸氨溴索对表皮葡萄球菌生物被膜的影响[J].中国超声医学杂志,2012,28(7):581-584.