阿奇霉素治疗或预防疟疾的研究进展
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摘要
阿奇霉素作为经典第二代大环内酯类抗生素,主要用于呼吸道感染性疾病。国内外多项研究表明,阿奇霉素能够有效治疗或预防包括疟疾在内的多种非细菌性感染性疾病。本文就阿奇霉素治疗或预防疟疾的研究进展做一综述。
Azithromycin,a typical kind of the second generation macrolide antibiotics,is mainly used to treat respiratory tracts infectious diseases. Many researches throughout the world indicate that azithromycin is able to treat or prevent many kinds of non-bacterial infectious diseases including malaria. This essay reviews the research progression of azithromycin in the treatment and protection of malaria.
Azithromycin,a typical kind of the second generation macrolide antibiotics,is mainly used to treat respiratory tracts infectious diseases. Many researches throughout the world indicate that azithromycin is able to treat or prevent many kinds of non-bacterial infectious diseases including malaria. This essay reviews the research progression of azithromycin in the treatment and protection of malaria.
引文
[1]Cheng SQ,Guo CH.The applying situation of macrolide antibiotics in non-bacterial infectious diseases[J].World Clin Drugs,2006,27(8):485-489.
[2]Muralidharan V,Striepen B.Teaching old drugs new tricks to stop malaria invasion in its tracks[J].BMC Biol,2015,13(1):72-72.
[3]Pechère JC.New perspectives on macrolide antibiotics[J].Int JAntimicrob Ag,2001,18(Suppl 1):93-97.
[4]WHO.World Malaria Report 2015[M].Switzerland:WHOPress,2015.
[5]丰俊,夏志贵.2004-2013年中国疟疾发病情况及趋势分析[J].中国病原生物学杂志,2014,9(5):442-446.Feng J,Xia ZG.Analysis of trends in cases of malaria reported from 2004 to July 2013 in the People′s Republic of China[J].Journal of Pathogen Biology,2014,9(5):442-446.
[6]Zhang L,Feng J,Xia ZG.Malaria situation in the People′s Republic of China in 2013[J].Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi,2014,32(6):407-413.
[7]Zhang L,Zhou SS,Feng J,et al.Malaria situation in the People′s Republic of China in 2014[J].Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi,2015,33(5):319-326.
[8]WHO.Global Technical Strategy for Malaria 2016-2030[M].Switzerland:WHO Press,2015.
[9]Ministry of Health P.R.C.China plan of eliminating malaria(2010-2020)[M].Beijing:Ministry of Health P.R.C.,2010.
[10]WHO.Global Report on Antimalarial Drug Efficacy and Drug Resistance 2000-2010[M].Switzerland:WHO Press,2010.
[11]Davidson DE,Ager AL,Brown JL,et al.New tissue schizontocidal antimalarial drugs[J].Bull WHO,1981,59(3):463-479.
[12]Andersen SL,Ger AL,Mcgreevy P,et al.Efficacy of azithromycin as a causal p roph ylacti c agent against murine malaria[J].Antimicrob Agents Chemother,1994,38(8):1862-1863.
[13]Neerja J,Puri SK.Plasmodium yoelii:activity of azithromycin in combination with pyrimethamine or sulfadoxine against blood and sporozoite induced infections in Swiss mice[J].Exp Parasitol,2004,107(3-4):120-124.
[14]He Y,Mao W,Lin KM,et al.Study on therapeutic effect of azithromycin on Plasmodium cynomolgi malaria[J].J of Path Bio,2008,3(9):665-666.
[15]He Y.Combinations drug effect of chloroquine and azithromycin on Plasmodium berghei in mice[D].Guangxi Medical University,2009.
[16]Ou DJ.Observational study on platelet dynamic change and different drugs intervention in malaria animal model[D].Guangxi Medical University,2011.
[17]Ou DJ,Wei HY,Zou CY,et al.Dynamic changes of platelets during Plasmodium cynomolgi infection and after drug treatments in rhesus monkeys[J].Chin JInfect Dis,2011,1(29):18-20.
[18]Noedl H,Wernsdorfer WH,Krudsood S,et al.Antimalarial activity of azithromycin,artemisinin and dihydroartemisinin in fresh isolates of Plasmodium falciparum in Thailand[J].Acta Trop,2001,80(1):39-44.
[19]Ohrt C,Willingmyre GD,Lee P,et al.Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro[J].Antimicrob Agents Chemother,2002,8(46):2518-2524.
[20]Nakornchai S,Konthiang P.Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro[J].Acta Trop,2006,100(3):185-191.
[21]李豫,陈华,杨恒林.萘酚喹单用及其与阿奇霉素伍用体外抑制恶性疟原虫作用研究[J].中国病原生物学杂志,2011,6(7):505-506,520.Li Y,Chen H,Yang HL.In vitro response of Plasmodium falciparum to naphthoquine combined with azithromycin[J].Journal of Pathogen Biology,2011,6(7):505-506,520.
[22]陈华.复方萘酚阿奇对延缓恶性疟原虫抗性的实验性研究[D].大理:大理学院,2011.Chen H.Study on naphthoquine with azithromycin combined with Plasmodium falciparum resistance to the delay experimental in laboratory[D].Dali:Dali University,2011.
[23]Fichera ME,Roos DS.A plastid organelle as a drug target in apicomplexan parasites[J].Nature,1997,390(6658):407-409.
[24]Dahl EL,Rosenthal PJ.Apicoplast translation,transcription and genome replication:targets for antimalarial antibiotics[J].Trends Parasitol,2008,24(6):279-284.
[25]Schlünzen F,Harms JM,Franceschi F,et al.Structural basis for the antibiotic activity of ketolides and azalides[J].Structure,2003,11(3):329-338.
[26]Retsema J,Fu W.Macrolides:structures and microbial targets[J].Int J Antimicrob Agents,2001,18Suppl 1:S3-10.
[27]Yeh E,De Risi JL.Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum[J].PLo S Biol,2011,9(8):e1001138.
[28]Wilson DW,Goodman CD,Sleebs BE,et al.Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite,Plasmodium falciparum[J].BMC Biol,2015,13:52.
[29]Rosenthal PJ.Azithromycin for Malaria[J]?Am J Trop Med Hyg,2016,95(1):2-4.
[30]Andersen SL,Oloo AJ,Gordon DM,et al.Successful doubleblinded,randomized,placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya[J].Clin Infect Dis,1998,26(1):146-150.
[31]Gilliams EA,Jumare J,Claassen CW,et al.Chloroquineazithromycin combination antimalarial treatment decreases risk of respiratory-and gastrointestinal-tract infections in malawian children[J].J Infect Dis,2014,210(4):585-592.
[32]Taylor WR,Richie TL,Fryauff DJ,et al.Tolerability of azithromycin as malaria prophylaxis in adults in northeast Papua,Indonesia[J].Antimicrob Agents Chemother,2003,47(7):2199-2203.
[33]Sadiq ST,Glasgow KW,Drakeley CJ,et al.Effects of azithromycin on malariometric indices in The Gambia[J].The Lancet,1995,346(8979):881-882.
[34]Dunne MW,Singh N,Shukla M,et al.A multicenter study of azithromycin,alone and in combination with chloroquine,for the treatment of acute uncomplicated Plasmodium falciparummalaria in India[J].J Infect Dis,2005,191(10):1582-1588.
[35]Noedl H,Krudsood S,Leowattana W,et al.In vitro antimalarial activity of azithromycin,artesunate,and quinine in combination and correlation with clinical outcome[J].Antimicrob Agents Chemother,2007,51(2):651-656.
[36]Kalilani L,Mofolo I,Chaponda M,et al.A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxinepyrimethamine as treatment for malaria in pregnant women[J].PLo S One,2007,11(2):e1166-1166.
[37]Thriemer K,Starzengruber P,Khan WA,et al.Azithromycin combination therapy for the treatment of uncomplicated falciparum malaria in Bangladesh:an open-label randomized,controlled clinical tria[lJ].J Infect Dis,2010,202(3):392-398.
[38]Shibahara D,Kinjo T,Nishiyama N,et al.Falciparum malaria incidentally pretreated with azithromycin[J].Internal Med,2015,54(19):2513-2516.
[39]van Eijk AM,Terlouw DJ.Azithromycin for treating uncomplicated malaria[J].Cochrane Database Syst Rev,2011,(2):CD006688.
[2]Muralidharan V,Striepen B.Teaching old drugs new tricks to stop malaria invasion in its tracks[J].BMC Biol,2015,13(1):72-72.
[3]Pechère JC.New perspectives on macrolide antibiotics[J].Int JAntimicrob Ag,2001,18(Suppl 1):93-97.
[4]WHO.World Malaria Report 2015[M].Switzerland:WHOPress,2015.
[5]丰俊,夏志贵.2004-2013年中国疟疾发病情况及趋势分析[J].中国病原生物学杂志,2014,9(5):442-446.Feng J,Xia ZG.Analysis of trends in cases of malaria reported from 2004 to July 2013 in the People′s Republic of China[J].Journal of Pathogen Biology,2014,9(5):442-446.
[6]Zhang L,Feng J,Xia ZG.Malaria situation in the People′s Republic of China in 2013[J].Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi,2014,32(6):407-413.
[7]Zhang L,Zhou SS,Feng J,et al.Malaria situation in the People′s Republic of China in 2014[J].Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi,2015,33(5):319-326.
[8]WHO.Global Technical Strategy for Malaria 2016-2030[M].Switzerland:WHO Press,2015.
[9]Ministry of Health P.R.C.China plan of eliminating malaria(2010-2020)[M].Beijing:Ministry of Health P.R.C.,2010.
[10]WHO.Global Report on Antimalarial Drug Efficacy and Drug Resistance 2000-2010[M].Switzerland:WHO Press,2010.
[11]Davidson DE,Ager AL,Brown JL,et al.New tissue schizontocidal antimalarial drugs[J].Bull WHO,1981,59(3):463-479.
[12]Andersen SL,Ger AL,Mcgreevy P,et al.Efficacy of azithromycin as a causal p roph ylacti c agent against murine malaria[J].Antimicrob Agents Chemother,1994,38(8):1862-1863.
[13]Neerja J,Puri SK.Plasmodium yoelii:activity of azithromycin in combination with pyrimethamine or sulfadoxine against blood and sporozoite induced infections in Swiss mice[J].Exp Parasitol,2004,107(3-4):120-124.
[14]He Y,Mao W,Lin KM,et al.Study on therapeutic effect of azithromycin on Plasmodium cynomolgi malaria[J].J of Path Bio,2008,3(9):665-666.
[15]He Y.Combinations drug effect of chloroquine and azithromycin on Plasmodium berghei in mice[D].Guangxi Medical University,2009.
[16]Ou DJ.Observational study on platelet dynamic change and different drugs intervention in malaria animal model[D].Guangxi Medical University,2011.
[17]Ou DJ,Wei HY,Zou CY,et al.Dynamic changes of platelets during Plasmodium cynomolgi infection and after drug treatments in rhesus monkeys[J].Chin JInfect Dis,2011,1(29):18-20.
[18]Noedl H,Wernsdorfer WH,Krudsood S,et al.Antimalarial activity of azithromycin,artemisinin and dihydroartemisinin in fresh isolates of Plasmodium falciparum in Thailand[J].Acta Trop,2001,80(1):39-44.
[19]Ohrt C,Willingmyre GD,Lee P,et al.Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro[J].Antimicrob Agents Chemother,2002,8(46):2518-2524.
[20]Nakornchai S,Konthiang P.Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro[J].Acta Trop,2006,100(3):185-191.
[21]李豫,陈华,杨恒林.萘酚喹单用及其与阿奇霉素伍用体外抑制恶性疟原虫作用研究[J].中国病原生物学杂志,2011,6(7):505-506,520.Li Y,Chen H,Yang HL.In vitro response of Plasmodium falciparum to naphthoquine combined with azithromycin[J].Journal of Pathogen Biology,2011,6(7):505-506,520.
[22]陈华.复方萘酚阿奇对延缓恶性疟原虫抗性的实验性研究[D].大理:大理学院,2011.Chen H.Study on naphthoquine with azithromycin combined with Plasmodium falciparum resistance to the delay experimental in laboratory[D].Dali:Dali University,2011.
[23]Fichera ME,Roos DS.A plastid organelle as a drug target in apicomplexan parasites[J].Nature,1997,390(6658):407-409.
[24]Dahl EL,Rosenthal PJ.Apicoplast translation,transcription and genome replication:targets for antimalarial antibiotics[J].Trends Parasitol,2008,24(6):279-284.
[25]Schlünzen F,Harms JM,Franceschi F,et al.Structural basis for the antibiotic activity of ketolides and azalides[J].Structure,2003,11(3):329-338.
[26]Retsema J,Fu W.Macrolides:structures and microbial targets[J].Int J Antimicrob Agents,2001,18Suppl 1:S3-10.
[27]Yeh E,De Risi JL.Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum[J].PLo S Biol,2011,9(8):e1001138.
[28]Wilson DW,Goodman CD,Sleebs BE,et al.Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite,Plasmodium falciparum[J].BMC Biol,2015,13:52.
[29]Rosenthal PJ.Azithromycin for Malaria[J]?Am J Trop Med Hyg,2016,95(1):2-4.
[30]Andersen SL,Oloo AJ,Gordon DM,et al.Successful doubleblinded,randomized,placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya[J].Clin Infect Dis,1998,26(1):146-150.
[31]Gilliams EA,Jumare J,Claassen CW,et al.Chloroquineazithromycin combination antimalarial treatment decreases risk of respiratory-and gastrointestinal-tract infections in malawian children[J].J Infect Dis,2014,210(4):585-592.
[32]Taylor WR,Richie TL,Fryauff DJ,et al.Tolerability of azithromycin as malaria prophylaxis in adults in northeast Papua,Indonesia[J].Antimicrob Agents Chemother,2003,47(7):2199-2203.
[33]Sadiq ST,Glasgow KW,Drakeley CJ,et al.Effects of azithromycin on malariometric indices in The Gambia[J].The Lancet,1995,346(8979):881-882.
[34]Dunne MW,Singh N,Shukla M,et al.A multicenter study of azithromycin,alone and in combination with chloroquine,for the treatment of acute uncomplicated Plasmodium falciparummalaria in India[J].J Infect Dis,2005,191(10):1582-1588.
[35]Noedl H,Krudsood S,Leowattana W,et al.In vitro antimalarial activity of azithromycin,artesunate,and quinine in combination and correlation with clinical outcome[J].Antimicrob Agents Chemother,2007,51(2):651-656.
[36]Kalilani L,Mofolo I,Chaponda M,et al.A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxinepyrimethamine as treatment for malaria in pregnant women[J].PLo S One,2007,11(2):e1166-1166.
[37]Thriemer K,Starzengruber P,Khan WA,et al.Azithromycin combination therapy for the treatment of uncomplicated falciparum malaria in Bangladesh:an open-label randomized,controlled clinical tria[lJ].J Infect Dis,2010,202(3):392-398.
[38]Shibahara D,Kinjo T,Nishiyama N,et al.Falciparum malaria incidentally pretreated with azithromycin[J].Internal Med,2015,54(19):2513-2516.
[39]van Eijk AM,Terlouw DJ.Azithromycin for treating uncomplicated malaria[J].Cochrane Database Syst Rev,2011,(2):CD006688.