青蒿素抗疟研究的不断追求:快速消灭疟疾——纪念执行“523”任务50周年
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摘要
在国家"523"(防治疟疾新药项目代号)任务实施50周年之际,对广州中医药大学青蒿素抗疟研究科研团队采用青蒿素复方防治疟疾的历程与所取得的进展进行评述。广州中医药大学作为"523"项目研究小组之一,其青蒿素抗疟研究科研团队相继主持了采用青蒿素及其衍生物不同剂型、剂量、疗程治疗疟疾的临床研究(1974~1989)、青蒿素复方(Artekin及Artequick)治疗疟疾的临床研究(1984~2006),并于近10年中在东南亚地区及非洲全力推行快速消灭传染源清除疟疾(Fast Elimination of Malaria by Source Eradication,FEMSE)的抗疟项目。青蒿素抗疟研究科研团队所做的探索与获得的成就为青蒿素类药物走向世界做出了重要贡献,并为全球快速消灭疟疾创建了一种简单、易行、省钱的新方法。
At the 50 th Anniversary of Project 523,we reviewed the course and progress made by the Artemisinin Anti-malaria Research Group of Guangzhou University of Chinese Medicine in the application of artemisinin for treating malaria. As one of the groups participating in the mission of Project 523, Artemisinin Anti-malaria Research Group of Guangzhou University of Chinese Medicine was in charge of the clinical trials in treating malaria with artemisinin and its derivatives of various preparation forms,dosages and treatment courses(years 1974-1989),developed the artemisinin-based combinations(ACTs)Artekin and Artequick for malaria treatment and performed their clinical trials(years 1984-2006). For the recent 10 years,the group has been devoted in the implementation of anti-malaria programme FEMSE(Fast Elimination of Malaria by Source Eradication) in south-east Asia and Africa. The scientific explorations and achievements of this research group have made great contribution in bringing artemisinins to the world and creating a simple, practical and cost-effective new method for rapid global malaria elimination.
At the 50 th Anniversary of Project 523,we reviewed the course and progress made by the Artemisinin Anti-malaria Research Group of Guangzhou University of Chinese Medicine in the application of artemisinin for treating malaria. As one of the groups participating in the mission of Project 523, Artemisinin Anti-malaria Research Group of Guangzhou University of Chinese Medicine was in charge of the clinical trials in treating malaria with artemisinin and its derivatives of various preparation forms,dosages and treatment courses(years 1974-1989),developed the artemisinin-based combinations(ACTs)Artekin and Artequick for malaria treatment and performed their clinical trials(years 1984-2006). For the recent 10 years,the group has been devoted in the implementation of anti-malaria programme FEMSE(Fast Elimination of Malaria by Source Eradication) in south-east Asia and Africa. The scientific explorations and achievements of this research group have made great contribution in bringing artemisinins to the world and creating a simple, practical and cost-effective new method for rapid global malaria elimination.
引文
[1]云南省药物研究所、广州中医学院523小组.黄蒿素治疗疟疾18例小结[C].疟疾防治研究资料汇编(云南),1977(2):38.
[2]张剑方.迟到的报告五二三项目与青蒿素研发纪实[M].广州:羊城晚报出版社,2006:27-32.
[3]青蒿素研究(全国)协作组.抗疟新药青蒿素的研究[J].药学通报,1979,14(2):49.
[4]李国桥,李英,李泽琳,等.青蒿素类抗疟药[M].北京:科学出版社,2015.
[5]李国桥,郭兴伯,简华香,等.青蒿素栓剂治疗恶性疟100例疗效观察[J].中医杂志,1984(5):26.
[6]郭兴伯,符林春,简华香,等.青蒿素栓治疗凶险型疟疾32例临床报告[J].广州中医学院学报,1986,3(4):15.
[7]郭兴伯,李国桥.青蒿素栓剂治疗疟疾463例资料综合(青蒿素栓新药申报资料临床研究部分)[G].广州:1984.
[8]郭兴伯,符林春,刘光平,等.青蒿琥酯静脉注射治疗恶性疟173例[J].广州中医学院学报,1988,5(1):9.
[9]郭兴伯,符林春,李国桥.青蒿琥酯静脉注射7天疗程治疗恶性疟疗效观察[J].广州中医学院学报,1989,6(1):39.
[10]郭兴伯,符林春,范太涛,等.青蒿琥酯静脉注射治疗脑型疟33例临床报告[J].广州中医学院学报,1992,9(1):1.
[11]符林春,王新华,郭兴伯,等.青蒿琥酯治疗脑型疟的临床疗效[J].广州中医药大学学报,1998,15(1):27.
[12]李国桥,郭兴伯,符林春,等.青蒿琥酯静脉注射治疗疟疾临床研究资料综合(青蒿琥酯注射剂新药申报资料临床研究部分)[G].广州:1986.
[13]符林春,郭兴伯,附永新,等.青蒿琥酯肌肉注射治疗恶性疟疗效探索与哌喹的随机比较.青蒿素类药临床研究专辑[G].广州:1990.
[14]符林春,李广谦,郭兴伯,等.青蒿琥酯片治疗恶性疟的剂量再探索[J].广州中医药大学学报,1998,15(2):81.
[15]郭兴伯,符永新,陈沛泉,等.青蒿琥酯片治疗恶性疟100例的临床观察[J].中华医学杂志,1998,15(2):81.
[16]李广谦,郭卫中,郑其进,等.甲氟喹治疗恶性疟与青蒿琥酯的随机比较[J].广州中医药大学学报,1997,14(3):163.
[17]郭卫中,郑其进,李广谦,等.萘酚喹治疗恶性疟与青蒿琥酯的随机比较[J].广州中医药大学学报,2000,17(3):235.
[18]Li G Q,Anorld k,Guo X B,et al.Randomised comparative study of mefloquine,qinghaosu,and S-P in patients with falciparum malaria(甲氟喹、青蒿素和周效磺胺—乙胺嘧啶配伍治疗恶性疟的随机比较)[J].Lancet,1984,2(8416):1360.
[19]宋建平,徐颖,欧凤珍,等.复方双氢青蒿素2天疗程治疗恶性疟50例[J].广州中医药大学学报,2000,17(3):238.
[20]宋建平,徐颖,欧凤珍,等.复方萘酚喹治疗恶性疟疾的剂量探索[J].广州中医药大学学报,2001,18(1):19.
[21]宋建平,陈沛泉,徐颖,等.两种双氢青蒿素复方治疗海南岛无并发症恶性疟的临床对照研究[J].广州中医药大学学报,2004,21(1):9.
[22]谈博,宋健平,Thou Tharith,等.含与不含甲氧苄啶的两个双氢青蒿素复方治疗恶性疟的临床对照试验[J].广州中医药大学学报,2007,24(2):100.
[23]邓长生,谈博,Duong S,等.青蒿素哌喹片治疗间日疟62例临床报道[J].广州中医药大学学报,2008,25(3):204.
[24]陈沛泉,李国桥,郭兴伯,等.青蒿琥酯对恶性疟原虫配子体感染体影响的观察[J].中药新药与临床药理,1993,4(3):40.
[25]陈沛泉,李国桥,郭兴伯,等.青蒿素对恶性疟配子体感染性的影响[J].中华医学杂志,1994,74(4):209.
[26]Li G Q,Chen P Q,Li G M,et al.Effect of artesunate on the infectivity of plasmodium falciparum gametocytes(PFG)and a randomied comparative study with quinine.XIVth International Congress for Tropical Medicine and Malaria[C].Nagasaki,Japan:1996.
[27]简华香,陈沛泉,符林春,等.青蒿琥酯对恶性疟原虫早期配子体的作用[J].广州中医药大学学报,1998,15(1):31.
[28]陈沛泉,简华香,符林春,等.双氢青蒿素和奎宁对恶性疟原虫早期配子体作用的随机比较[J].广州中医药大学学报,2001,18(1):22.
[29]邓长生,宋健平,谈博,等.青蒿素哌喹片联合伯氨喹治疗科摩罗无并发症恶性疟临床疗效观察(英文)[J].广州中医药大学学报,2012,29(2):197.
[30]李国桥,宋健平,邓长生,等.Moheli岛快速灭源灭疟法实施1年报告(英文)[J].广州中医药大学学报,2010,27(1):90.
[31]李国铭,周耀芳,冯丽玲,等,套式PCR检测试剂盒用于普查疟疾带虫率的评价(英文)[J].广州中医药大学学报,2013,30(6):839.
[32]Feng L L,Luo X L,Zhou Y F,et al.Fast elimination of malaria by infectious source eradication with artemisinin-based compound[J].Science China-Life Sciences,2016,59(1):78.
[2]张剑方.迟到的报告五二三项目与青蒿素研发纪实[M].广州:羊城晚报出版社,2006:27-32.
[3]青蒿素研究(全国)协作组.抗疟新药青蒿素的研究[J].药学通报,1979,14(2):49.
[4]李国桥,李英,李泽琳,等.青蒿素类抗疟药[M].北京:科学出版社,2015.
[5]李国桥,郭兴伯,简华香,等.青蒿素栓剂治疗恶性疟100例疗效观察[J].中医杂志,1984(5):26.
[6]郭兴伯,符林春,简华香,等.青蒿素栓治疗凶险型疟疾32例临床报告[J].广州中医学院学报,1986,3(4):15.
[7]郭兴伯,李国桥.青蒿素栓剂治疗疟疾463例资料综合(青蒿素栓新药申报资料临床研究部分)[G].广州:1984.
[8]郭兴伯,符林春,刘光平,等.青蒿琥酯静脉注射治疗恶性疟173例[J].广州中医学院学报,1988,5(1):9.
[9]郭兴伯,符林春,李国桥.青蒿琥酯静脉注射7天疗程治疗恶性疟疗效观察[J].广州中医学院学报,1989,6(1):39.
[10]郭兴伯,符林春,范太涛,等.青蒿琥酯静脉注射治疗脑型疟33例临床报告[J].广州中医学院学报,1992,9(1):1.
[11]符林春,王新华,郭兴伯,等.青蒿琥酯治疗脑型疟的临床疗效[J].广州中医药大学学报,1998,15(1):27.
[12]李国桥,郭兴伯,符林春,等.青蒿琥酯静脉注射治疗疟疾临床研究资料综合(青蒿琥酯注射剂新药申报资料临床研究部分)[G].广州:1986.
[13]符林春,郭兴伯,附永新,等.青蒿琥酯肌肉注射治疗恶性疟疗效探索与哌喹的随机比较.青蒿素类药临床研究专辑[G].广州:1990.
[14]符林春,李广谦,郭兴伯,等.青蒿琥酯片治疗恶性疟的剂量再探索[J].广州中医药大学学报,1998,15(2):81.
[15]郭兴伯,符永新,陈沛泉,等.青蒿琥酯片治疗恶性疟100例的临床观察[J].中华医学杂志,1998,15(2):81.
[16]李广谦,郭卫中,郑其进,等.甲氟喹治疗恶性疟与青蒿琥酯的随机比较[J].广州中医药大学学报,1997,14(3):163.
[17]郭卫中,郑其进,李广谦,等.萘酚喹治疗恶性疟与青蒿琥酯的随机比较[J].广州中医药大学学报,2000,17(3):235.
[18]Li G Q,Anorld k,Guo X B,et al.Randomised comparative study of mefloquine,qinghaosu,and S-P in patients with falciparum malaria(甲氟喹、青蒿素和周效磺胺—乙胺嘧啶配伍治疗恶性疟的随机比较)[J].Lancet,1984,2(8416):1360.
[19]宋建平,徐颖,欧凤珍,等.复方双氢青蒿素2天疗程治疗恶性疟50例[J].广州中医药大学学报,2000,17(3):238.
[20]宋建平,徐颖,欧凤珍,等.复方萘酚喹治疗恶性疟疾的剂量探索[J].广州中医药大学学报,2001,18(1):19.
[21]宋建平,陈沛泉,徐颖,等.两种双氢青蒿素复方治疗海南岛无并发症恶性疟的临床对照研究[J].广州中医药大学学报,2004,21(1):9.
[22]谈博,宋健平,Thou Tharith,等.含与不含甲氧苄啶的两个双氢青蒿素复方治疗恶性疟的临床对照试验[J].广州中医药大学学报,2007,24(2):100.
[23]邓长生,谈博,Duong S,等.青蒿素哌喹片治疗间日疟62例临床报道[J].广州中医药大学学报,2008,25(3):204.
[24]陈沛泉,李国桥,郭兴伯,等.青蒿琥酯对恶性疟原虫配子体感染体影响的观察[J].中药新药与临床药理,1993,4(3):40.
[25]陈沛泉,李国桥,郭兴伯,等.青蒿素对恶性疟配子体感染性的影响[J].中华医学杂志,1994,74(4):209.
[26]Li G Q,Chen P Q,Li G M,et al.Effect of artesunate on the infectivity of plasmodium falciparum gametocytes(PFG)and a randomied comparative study with quinine.XIVth International Congress for Tropical Medicine and Malaria[C].Nagasaki,Japan:1996.
[27]简华香,陈沛泉,符林春,等.青蒿琥酯对恶性疟原虫早期配子体的作用[J].广州中医药大学学报,1998,15(1):31.
[28]陈沛泉,简华香,符林春,等.双氢青蒿素和奎宁对恶性疟原虫早期配子体作用的随机比较[J].广州中医药大学学报,2001,18(1):22.
[29]邓长生,宋健平,谈博,等.青蒿素哌喹片联合伯氨喹治疗科摩罗无并发症恶性疟临床疗效观察(英文)[J].广州中医药大学学报,2012,29(2):197.
[30]李国桥,宋健平,邓长生,等.Moheli岛快速灭源灭疟法实施1年报告(英文)[J].广州中医药大学学报,2010,27(1):90.
[31]李国铭,周耀芳,冯丽玲,等,套式PCR检测试剂盒用于普查疟疾带虫率的评价(英文)[J].广州中医药大学学报,2013,30(6):839.
[32]Feng L L,Luo X L,Zhou Y F,et al.Fast elimination of malaria by infectious source eradication with artemisinin-based compound[J].Science China-Life Sciences,2016,59(1):78.