重庆市铜梁县妊娠妇女体内微营养素状况分析
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摘要
目的调查重庆市铜梁县妊娠妇女孕早期体内微营养素水平及其对新生儿体格发育的影响。方法对253例调查对象采空腹静脉血,检测血红蛋白及微营养素水平,并随访妊娠结局及新生儿体格发育指标,根据产重分为正常出生体质量、低出生体质量、巨大儿3组。结果孕早期妇女体内镁、红细胞叶酸的水平与新生儿出生体质量存在正向线性回归关系(P<0.05);铁、红细胞叶酸、孕早中期血红蛋白水平与新生儿身长存在正向线性回归关系(P<0.05);叶酸水平与新生儿头围存在正向线性回归关系(P<0.05);不同新生儿体质量孕期血红蛋白水平及新生儿身长和头围存在显著差异(P<0.05)。结论该地区孕早期孕妇仍然存在部分微营养素缺乏,应合理膳食,平衡营养。
Objective To investigate the micronutrients status of early-mid term gestation women in Tongliang,Chongqing and analyze its effects on neonatal physical development.Methods Blood was drawn from 253 objects of investigation in conformity to detect the levels of micronutrients.Information of pregnancy outcomes and neonatal physical indicators was retrieved from medical records after delivery.According to birth weight,they were divided into three groups:normal-birthweight newborns,low-birthweight newborns and giant newborns.Results There was positive liner-regression relationship in the changes of Magnesium and erythrocytic folate with newborn′s birthweight(P<0.05).There were positive liner-regression relationship in iron element,erythrocytic folate and hemoglobin of early-mid gestation with newborn′s birth length(P<0.05),folate level with newborn′s head circumference(P<0.05).The concentration of the hemoglobin,the birth length and head circumference had significant differences(P<0.05).Conclusion The early pregnant women in this area still exists part micronutrient deficiency.Women in early pregnancy should guide the diet and balance the nutrition.
Objective To investigate the micronutrients status of early-mid term gestation women in Tongliang,Chongqing and analyze its effects on neonatal physical development.Methods Blood was drawn from 253 objects of investigation in conformity to detect the levels of micronutrients.Information of pregnancy outcomes and neonatal physical indicators was retrieved from medical records after delivery.According to birth weight,they were divided into three groups:normal-birthweight newborns,low-birthweight newborns and giant newborns.Results There was positive liner-regression relationship in the changes of Magnesium and erythrocytic folate with newborn′s birthweight(P<0.05).There were positive liner-regression relationship in iron element,erythrocytic folate and hemoglobin of early-mid gestation with newborn′s birth length(P<0.05),folate level with newborn′s head circumference(P<0.05).The concentration of the hemoglobin,the birth length and head circumference had significant differences(P<0.05).Conclusion The early pregnant women in this area still exists part micronutrient deficiency.Women in early pregnancy should guide the diet and balance the nutrition.
引文
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[11]SMITH E R,SHANKAR A H,WU L S,et al.Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth,birth outcomes,and infant mortality:a meta-analysis of individual patient data from 17randomised trials in low-income and middle-income countries[J].Lancet Glob Health,2017,5(11):e1090-1100.
[12]滕晓晶,余昊徵,沈涌海,等.杭州地区不同妊娠期孕妇微量元素检测分析[J].中国卫生检验杂志,2015,25(18):3130-3132.
[13]NAMPIJJA M,APULE B,LULE S,et al.Effects of maternal worm infections and anthelminthic treatment during pregnancy on infant motor and neurocognitive functioning[J].J Int Neuropsychol Soc,2012,18(6):1019-1030.
[2]WESSELLS K R,OUDRAOGO C T,YOUNG R R,et al.Micronutrient status among pregnant women in zinder,niger and risk factors associated with deficiency[J].Nutrients,2017,9(5):E430.
[3]GUPTA P M,PERRINE C G,MEI Z,et al.Iron,anemia,and Iron deficiency anemia among young children in the United States[J].Nutrients,2016,8(6):E330.
[4]AGNOLI C,GRIONI S,KROGH V,et al.Plasma riboflavin and vitamin B-6,but not homocysteine,folate,or vitamin B-12,are inversely associated with breast cancer risk in the European prospective investigation into cancer and nutrition varese cohort[J].J Nutr,2016,146(6):1227-1234.
[5]徐凤英,徐水芳,刘德慧,等.微量元素与胎儿生长受限关系研究[J].中国实用妇科与产科杂志,2015,31(12):1155-1157.
[6]STEVENS G A,BENNETT J E,HENNOCQ Q,et al.Trends and mortality effects of vitamin a deficiency in children in 138low-income and middle-income countries between 1991and 2013:apooled analysis of populationbased surveys[J].Lancet Glob Health,2015,3(9):e528-536.
[7]RONNENBERG A G,GOLDMAN M B,CHEN D,et al.Preconception homocysteine and B vitamin status and birth outcomes in Chinese women[J].Am J Clin Nutr,2002,76(6):1385-1391.
[8]李慕军,冯启明.孕妇妊娠不同时期的焦虑抑郁状况变化分析[J].中国妇幼保健,2005,20(10):1193-1194.
[9]AHMED F,AL-SUMAIE M A.Risk factors associated with anemia and Iron deficiency among Kuwaiti pregnant women[J].Int J Food Sci Nutr,2011,62(6):585-592.
[10]YANG T,GU Y,WEI X P,et al.Periconceptional folic acid supplementation and vitamin B12status in a cohort of Chinese early pregnancy women with the risk of adverse pregnancy outcomes[J].J Clin Biochem Nutr,2017,60(2):136-142.
[11]SMITH E R,SHANKAR A H,WU L S,et al.Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth,birth outcomes,and infant mortality:a meta-analysis of individual patient data from 17randomised trials in low-income and middle-income countries[J].Lancet Glob Health,2017,5(11):e1090-1100.
[12]滕晓晶,余昊徵,沈涌海,等.杭州地区不同妊娠期孕妇微量元素检测分析[J].中国卫生检验杂志,2015,25(18):3130-3132.
[13]NAMPIJJA M,APULE B,LULE S,et al.Effects of maternal worm infections and anthelminthic treatment during pregnancy on infant motor and neurocognitive functioning[J].J Int Neuropsychol Soc,2012,18(6):1019-1030.