水解蛋白在婴幼儿营养配方食品中应用的研究进展
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摘要
水解蛋白分子量低,适合消化系统不成熟、免疫系统不完善的婴幼儿消化吸收,可以满足婴幼儿对蛋白质的营养需求,并对乳蛋白过敏性疾病起到了一定的预防与辅助性治疗作用。本文介绍了水解蛋白的性质,在婴幼儿营养配方食品中的应用及其营养特性,同时对水解蛋白的生产工艺、质量控制及相应标准进行了阐述。
The hydrolyzed protein with low molecular weights is suitable for infants with immature digestive system and imperfect immune system. It can satisfy the nutritional needs of infants and play a significant role in the prevention and treatment of allergic diseases. In this paper,the properties and application of hydrolyzed protein and function of hydrolyzed protein formula were introduced.Meanwhile,the production of hydrolyzed protein and corresponding standard were reviewed.
The hydrolyzed protein with low molecular weights is suitable for infants with immature digestive system and imperfect immune system. It can satisfy the nutritional needs of infants and play a significant role in the prevention and treatment of allergic diseases. In this paper,the properties and application of hydrolyzed protein and function of hydrolyzed protein formula were introduced.Meanwhile,the production of hydrolyzed protein and corresponding standard were reviewed.
引文
[1]Lessen R,Kavanagh K.Position of the academy of nutrition and dietetics:promoting and supporting breastfeeding[J].Journal of the Academy of Nutrition&Dietetics,2015,115(3):444-449.
[2]金世琳.乳品生物化学[M].北京:中国轻工业出版社,1983:189.
[3]Wood RA.The natural history of food allergy[J].Pediatrics,2003,111:1631-1637.
[4]Rene Koopman,Nico Crombach,Annemie P Gijsen,et al.Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein[J].American Journal of Clinical Nutrition,2009,90(1):106-115.
[5]Exl B-M,Vandenplas Y,Blecker U.Role of hydrolyzed formulae in nutritional allergy prevention in infants[J].Southern Medical Journal,1997,90(12):1170-1175.
[6]Peyquet S,Bovetto L,Maynard F,Fritsche R.Peptides obtained by tryptic hydrolysis of bovine betalactoglobulin induce specific oral tolerance in mice[J].Allergy Clin Immun,2000,105(3):514-521.
[7]Vandenplas Y,Hauser B,Blecker U,et al.The nutritional value of a whey-hydroysed formula compared with a wheypredominant formula in healthy infants[J].Pediatr Gastroenterol Nutr,1993,17:92-96.
[8]Aggett PJ,Haschke F,Heine W,et al.Comment on antigenreduced infant formulae[J].Acta Paediatr Scand,1993,82(3):314-319.
[9]Baker SS,Cochran WJ,Greer FR,et al.Hypoallergenic Infant Formulas[J].Pediatrics,2000,106:346-349.
[10]Chandra RK.Five-year follow-up of high-risk infants with family history of allergy who were exclusively breast-fed or fed partial hydrolysate,soy,and conventional cow’s milk formulae[J].Ped Gastroent Nutr,1997,24(4):380.
[11]Bianca-Maria Exl.A review of recent developments in the use of moderately hydrolyzed whey formulae in infant nutrition[J].Nutrition Research,2001,21(1-2):355-379.
[12]AAP Committee on Nutrition(Baker SS,Cochran WJ,Greer FR,Heyman MB,Jacobson MS,Jaksic T,Krebs NF).Hypoallergenic Infant Formulas[J].Pediatrics,2000,106:346-349.
[13]韩军花,李晓瑜.特殊食品国内外法规标准比对研究[M].北京:中国医药科技出版社,2017.
[14]向莉.水解蛋白婴儿配方研究进展[J].临床儿科杂志,2009,27(8):794-797.
[15]中华医学会儿科学分会免疫学组,儿童保健学组,消化学组.中国婴幼儿牛奶蛋白过敏诊治循证建议[J].中华儿科杂志,2013,51(3):183-186.
[16]Vanderhoof JA.In time:Misuse and overuse of amino acid formulas in cow milk allergy[J].Revista Paulista De pediatria,2015,33(4):379-380.
[17]Vandenplas Y,Alarcon P,Fleischer D,et al.Should Partial Hydrolysates Be Used As Starter Infant Formula?A Working Group Consensus[J].J Pediatr Gastroenterol Nutr,2016,62(1):22-35.
[18]黄晓虹.水解蛋白配方奶粉对新生儿外科肠道手术后康复及体重增长的影响[J].中医临床研究,2015,7(21):113-115.
[19]罗智花,王杨,王琍琍.深度水解蛋白奶粉喂养极/超低出生体重儿的临床研究[J].中国新生儿科杂志,2016,31(2):110-114.
[20]陈科,李琴,谢胡咪娜,等.适度水解蛋白配方奶粉早期使用对婴儿湿疹预防作用观察[J].临床与病理杂志,2016,36(2):128-131.
[21]Berg AV,Koletzko S,Filipiak-Pittroff B,et al.Certain hydrolyzed formulas reduce the incidence ofatopic dermatitis but not that of asthma:three-yearresults of the German Infant Nutritional InterventionS tudy[J].Journal of Allergy&Clinical Immunology,2007,119(119):718-725.
[22]Bhanegaonkar A,Horodniceanu EG,Ji X,et al.Economic Burden of Atopic Dermatitis in High-Risk Infants ReceivingC ow's Milk or Partially Hydrolyzed 100%Whey-Based Formula[J].Journal of Pediatrics,2015,120(5):1145-1151.
[23]Marini A,Agosti M,Motta G,et al.Effects of a dietary and environmental prevention programme on the incidence of allergic symptoms in high atopic risk infants:three years follow-up[J].Acta Paediatrica Supplement,1996,414(Supplement s414):1-21.
[24]Staelen S,Van MD,Carrie A,et al.Gastric emptying in healthy newborns fed an intact protein formula,a partially and an extensively hydrolysed formula[J].Clinical Nutrition,2008,27(2):264-268.
[25]Mihatsch WA,Franz AR,Hogel J,et al.Hydrolyzed protein accelerates feeding advancement in very low birth weight infants[J].Pediatrics,2002,110(6):1199.
[26]张少冰,崔其亮,钟鑫琪,等.部分水解蛋白配方治疗婴儿功能性便秘的疗效分析[J].中国实用儿科杂志,2010,25(6):492.
[27]颜海青,谢丽,张茜.深度水解蛋白配方奶粉治疗婴儿牛奶蛋白过敏性腹泻的疗效[J].广东医学,2013,34(4):555-557.
[28]Aaslyng MD,Poll L,Nielsen PM.Sensory,chemical and sensometric studies of hydrolyzed vegetable protein produced by various processes[J].European Food Research&Technology,1999,209(3-4):227-236.
[29]Devaraju SK,Thatte P,J Prakash,JA Lakshmi.Bioaccessible iron and zinc in native and fortified enzyme hydrolyzed casein and soya protein matrices[J].Food Biotechnology,2016,30(4):233-248.
[30]Osborn DA,Sinn JK.Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants[J].Cochrane Database Syst Rev,2007,18(4):3664.
[31]齐晓彦,苏米亚.婴幼儿水解配方奶粉的研究进展[J].中国乳品工业,2016,44(3):46-50.
[32]Rugo E,Wahn R,Wahn U.How allergenic are hypoallergenic infant formulae[J].Clinical Experinebtal Allergy,1992,22(6):635-639.
[33]Vanderhoof JA,In time:Misuse and overuse of amino acid formulas in cow milk allergy[J].Revista Paulista De pediatria,2015 33(4):379-380.
[34]GB 11674-2010食品安全国家标准乳清粉和乳清蛋白粉[S].2010.
[35]GB 31638-2016食品安全国家标准酪蛋白[S].2016.
[36]国家食品药品监督管理总局.特殊医学用途配方食品注册管理办法[EB/OL].2016-03-10.
[37]国家食品药品监督管理总局.婴幼儿配方乳粉产品配方注册管理办法[EB/OL].2016-06-08.
[38]GB 25596-2010食品安全国家标准特殊医学用途婴儿配方食品通则[S].2010.
[2]金世琳.乳品生物化学[M].北京:中国轻工业出版社,1983:189.
[3]Wood RA.The natural history of food allergy[J].Pediatrics,2003,111:1631-1637.
[4]Rene Koopman,Nico Crombach,Annemie P Gijsen,et al.Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein[J].American Journal of Clinical Nutrition,2009,90(1):106-115.
[5]Exl B-M,Vandenplas Y,Blecker U.Role of hydrolyzed formulae in nutritional allergy prevention in infants[J].Southern Medical Journal,1997,90(12):1170-1175.
[6]Peyquet S,Bovetto L,Maynard F,Fritsche R.Peptides obtained by tryptic hydrolysis of bovine betalactoglobulin induce specific oral tolerance in mice[J].Allergy Clin Immun,2000,105(3):514-521.
[7]Vandenplas Y,Hauser B,Blecker U,et al.The nutritional value of a whey-hydroysed formula compared with a wheypredominant formula in healthy infants[J].Pediatr Gastroenterol Nutr,1993,17:92-96.
[8]Aggett PJ,Haschke F,Heine W,et al.Comment on antigenreduced infant formulae[J].Acta Paediatr Scand,1993,82(3):314-319.
[9]Baker SS,Cochran WJ,Greer FR,et al.Hypoallergenic Infant Formulas[J].Pediatrics,2000,106:346-349.
[10]Chandra RK.Five-year follow-up of high-risk infants with family history of allergy who were exclusively breast-fed or fed partial hydrolysate,soy,and conventional cow’s milk formulae[J].Ped Gastroent Nutr,1997,24(4):380.
[11]Bianca-Maria Exl.A review of recent developments in the use of moderately hydrolyzed whey formulae in infant nutrition[J].Nutrition Research,2001,21(1-2):355-379.
[12]AAP Committee on Nutrition(Baker SS,Cochran WJ,Greer FR,Heyman MB,Jacobson MS,Jaksic T,Krebs NF).Hypoallergenic Infant Formulas[J].Pediatrics,2000,106:346-349.
[13]韩军花,李晓瑜.特殊食品国内外法规标准比对研究[M].北京:中国医药科技出版社,2017.
[14]向莉.水解蛋白婴儿配方研究进展[J].临床儿科杂志,2009,27(8):794-797.
[15]中华医学会儿科学分会免疫学组,儿童保健学组,消化学组.中国婴幼儿牛奶蛋白过敏诊治循证建议[J].中华儿科杂志,2013,51(3):183-186.
[16]Vanderhoof JA.In time:Misuse and overuse of amino acid formulas in cow milk allergy[J].Revista Paulista De pediatria,2015,33(4):379-380.
[17]Vandenplas Y,Alarcon P,Fleischer D,et al.Should Partial Hydrolysates Be Used As Starter Infant Formula?A Working Group Consensus[J].J Pediatr Gastroenterol Nutr,2016,62(1):22-35.
[18]黄晓虹.水解蛋白配方奶粉对新生儿外科肠道手术后康复及体重增长的影响[J].中医临床研究,2015,7(21):113-115.
[19]罗智花,王杨,王琍琍.深度水解蛋白奶粉喂养极/超低出生体重儿的临床研究[J].中国新生儿科杂志,2016,31(2):110-114.
[20]陈科,李琴,谢胡咪娜,等.适度水解蛋白配方奶粉早期使用对婴儿湿疹预防作用观察[J].临床与病理杂志,2016,36(2):128-131.
[21]Berg AV,Koletzko S,Filipiak-Pittroff B,et al.Certain hydrolyzed formulas reduce the incidence ofatopic dermatitis but not that of asthma:three-yearresults of the German Infant Nutritional InterventionS tudy[J].Journal of Allergy&Clinical Immunology,2007,119(119):718-725.
[22]Bhanegaonkar A,Horodniceanu EG,Ji X,et al.Economic Burden of Atopic Dermatitis in High-Risk Infants ReceivingC ow's Milk or Partially Hydrolyzed 100%Whey-Based Formula[J].Journal of Pediatrics,2015,120(5):1145-1151.
[23]Marini A,Agosti M,Motta G,et al.Effects of a dietary and environmental prevention programme on the incidence of allergic symptoms in high atopic risk infants:three years follow-up[J].Acta Paediatrica Supplement,1996,414(Supplement s414):1-21.
[24]Staelen S,Van MD,Carrie A,et al.Gastric emptying in healthy newborns fed an intact protein formula,a partially and an extensively hydrolysed formula[J].Clinical Nutrition,2008,27(2):264-268.
[25]Mihatsch WA,Franz AR,Hogel J,et al.Hydrolyzed protein accelerates feeding advancement in very low birth weight infants[J].Pediatrics,2002,110(6):1199.
[26]张少冰,崔其亮,钟鑫琪,等.部分水解蛋白配方治疗婴儿功能性便秘的疗效分析[J].中国实用儿科杂志,2010,25(6):492.
[27]颜海青,谢丽,张茜.深度水解蛋白配方奶粉治疗婴儿牛奶蛋白过敏性腹泻的疗效[J].广东医学,2013,34(4):555-557.
[28]Aaslyng MD,Poll L,Nielsen PM.Sensory,chemical and sensometric studies of hydrolyzed vegetable protein produced by various processes[J].European Food Research&Technology,1999,209(3-4):227-236.
[29]Devaraju SK,Thatte P,J Prakash,JA Lakshmi.Bioaccessible iron and zinc in native and fortified enzyme hydrolyzed casein and soya protein matrices[J].Food Biotechnology,2016,30(4):233-248.
[30]Osborn DA,Sinn JK.Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants[J].Cochrane Database Syst Rev,2007,18(4):3664.
[31]齐晓彦,苏米亚.婴幼儿水解配方奶粉的研究进展[J].中国乳品工业,2016,44(3):46-50.
[32]Rugo E,Wahn R,Wahn U.How allergenic are hypoallergenic infant formulae[J].Clinical Experinebtal Allergy,1992,22(6):635-639.
[33]Vanderhoof JA,In time:Misuse and overuse of amino acid formulas in cow milk allergy[J].Revista Paulista De pediatria,2015 33(4):379-380.
[34]GB 11674-2010食品安全国家标准乳清粉和乳清蛋白粉[S].2010.
[35]GB 31638-2016食品安全国家标准酪蛋白[S].2016.
[36]国家食品药品监督管理总局.特殊医学用途配方食品注册管理办法[EB/OL].2016-03-10.
[37]国家食品药品监督管理总局.婴幼儿配方乳粉产品配方注册管理办法[EB/OL].2016-06-08.
[38]GB 25596-2010食品安全国家标准特殊医学用途婴儿配方食品通则[S].2010.