高血压脑出血早期强化降压的临床研究
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摘要
目的探讨早期强化降压治疗高血压脑出血的临床疗效。方法将68例高血压脑出血患者分为强化对照组(32例)和强化降压组(36例),对照组血压维持至150-170㎜Hg,强化降压组在短时间内将血压降至120-130㎜Hg,对两组血肿体积、水肿体积、血肿增大率等指标进行比较。结果与强化降压组相比,对照组血肿体积、水肿体积增大,血肿增大率及24h心电图变异率较高,差异有统计学(P<0.05)。结论早期强化降压有助于控制高血压脑出血血肿体积及周围水肿体积。
Objective To explore the curative effect of early strengthening hypotensive therapy for hypertensive cerebral hemorrhage. Methods 68 patients with hypertensive cerebral hemorrhage were divided into control group(32 cases) and early intensive antihypertensive group(36 cases) and control group maintain blood pressure to 150-170 mm Hg, early intensive antihypertensive group drop blood pressure to 120-130 mm Hg in a short time, hematoma volume, edema and the rate of increasing hematoma volume are compared. Results Compared with the early intensive antihypertensive group, the volume of hematoma and edema increased in the control group, the rate of increasing hematoma volume and the ECG variation were higher, the difference was statistically significant(P<0.05). Conclusion Early enhanced hypotension can help control the volume of hematoma and the surrounding edema volume in hypertensive intracerebral hemorrhage.
Objective To explore the curative effect of early strengthening hypotensive therapy for hypertensive cerebral hemorrhage. Methods 68 patients with hypertensive cerebral hemorrhage were divided into control group(32 cases) and early intensive antihypertensive group(36 cases) and control group maintain blood pressure to 150-170 mm Hg, early intensive antihypertensive group drop blood pressure to 120-130 mm Hg in a short time, hematoma volume, edema and the rate of increasing hematoma volume are compared. Results Compared with the early intensive antihypertensive group, the volume of hematoma and edema increased in the control group, the rate of increasing hematoma volume and the ECG variation were higher, the difference was statistically significant(P<0.05). Conclusion Early enhanced hypotension can help control the volume of hematoma and the surrounding edema volume in hypertensive intracerebral hemorrhage.
引文
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[8]马青峰,华琦.急性脑出血降压治疗的变化与争议[J].中华老年心脑血管病杂志,2017,19(04):440-441.
[9]陈皆春,孙德锦,葛中林,等.乌拉地尔强化降压治疗对高血压性脑出血患者血肿扩大的影响[J],临床神经病学杂志,2010,23(06):420-422.
[10]姜伟.乌拉地尔治疗脑出血急性高血压的疗效观察[J].医学理论与实践,2017,30(02):201-203.
[11]包红梅,包乌云.盐酸乌拉地尔治疗高血压脑出血术后40例临床观察[J].世界最新医学信息文摘,2017,17(59):110.
[12]何婧瑜,周玉杰,付研,等.乌拉地尔与硝酸甘油注射液治疗高血压合并急性心力衰竭患者有效性及安全性研究[J].中华老年心脑血管病杂志,2016,18(07):676-680.
[2]王锋,张素雅,朱瑾,等.早期强化降压治疗对高血压脑出血患者血肿和神经功能的影响[J].实用心脑肺血管病杂志,2017,25(02):150-152.
[3]Qaseem A,Timothy JW,Rich R,Linda LH,Frost J,Forciea MA.≥60岁高血压病人控制血压在较高或较低水平的药物治疗-美国医师协会和美国家庭医师学会临床实践指南[J].护理研究,2017,31(24):2945-2950.
[4]Thanvi BR,Sprigg N,Munshi SK.Advances in spontaneous intracerebral haemorrhage[J].Int J Clin Pract,2012,66(6):556-64.
[5]Mc Court R,Gould B,Gioia L,et al.Cerebral perfusion and blood pressure do not affect perihematoma edema growth in acute intracerebral hemorrhage[J].Stroke,2014,45(5):1292-8.
[6]Manning L,Hirakawa Y,Arima H,et al.Blood pressure variability and outcome after acute intracerebral haemorrhage:a post-hoc analysis of INTERACT2,a randomised controlled trial[J].Lancet Neurol,2014,13(4):364-73.
[7]刘佳佳,黎宏斐,沈福玉,等.早期强化降压治疗与高血压脑出血血肿、血肿周围水肿的关系[J].临床神经病学杂志,2015,28(04):299-301.
[8]马青峰,华琦.急性脑出血降压治疗的变化与争议[J].中华老年心脑血管病杂志,2017,19(04):440-441.
[9]陈皆春,孙德锦,葛中林,等.乌拉地尔强化降压治疗对高血压性脑出血患者血肿扩大的影响[J],临床神经病学杂志,2010,23(06):420-422.
[10]姜伟.乌拉地尔治疗脑出血急性高血压的疗效观察[J].医学理论与实践,2017,30(02):201-203.
[11]包红梅,包乌云.盐酸乌拉地尔治疗高血压脑出血术后40例临床观察[J].世界最新医学信息文摘,2017,17(59):110.
[12]何婧瑜,周玉杰,付研,等.乌拉地尔与硝酸甘油注射液治疗高血压合并急性心力衰竭患者有效性及安全性研究[J].中华老年心脑血管病杂志,2016,18(07):676-680.