摘要
为了对比分析2种含铋剂四联疗法联合双岐三联活菌胶囊分别对幽门螺杆菌(Helicobacter pylori,Hp)感染患者疗效的影响。本研究随机选取200例就诊的Hp感染患者,将患者随机分为4组,每组50例。A组(埃索美拉唑,克拉霉素,阿莫西林,枸橼酸铋钾胶囊)、B组(埃索美拉唑,呋喃唑酮,阿莫西林,枸橼酸铋钾胶囊)、C组(埃索美拉唑,克拉霉素,阿莫西林,枸橼酸铋钾胶囊,双歧杆菌三联活菌胶囊)和D组(埃索美拉唑,呋喃唑酮,阿莫西林,枸橼酸铋钾胶囊和双歧杆菌三联活菌胶囊)。分析对比四组患者的临床缓解疗效、幽门螺旋杆菌根除效率、不良反应、复发情况及成本效果比。研究表明:2种含铋剂四联疗法联合双岐三联活菌胶囊对幽门螺杆菌感染患者的临床缓解症状、幽门螺杆菌根除率效果、不良反应发生率和复发情况效果优于含铋剂四联疗法,但是D组成本效果比更具有经济学优势。埃索美拉唑、呋喃唑酮、阿莫西林、枸橼酸铋钾胶囊和双歧杆菌三联活菌胶囊联合可促进Hp患者恢复,根除率高,降低不良反应和复发率,且具有经济学优势,值得推广应用。
To compare and analyze the effects of two bismuth-containing quadruple therapies combined with Bifid Triple Viable capsules on the efficacy of Helicobacter pylori(Hp) patients. 200 patients with HP infection were randomly selected and randomly divided into four groups with 50 cases in each group. Group A(Esomeprazole,Clarithromycin, Amoxicillin, Bismuth Potassium Citrate Capsules), Group B(Esomeprazole, Furazolidone, Amoxicillin, Bismuth Potassium Citrate Capsules), Group C(Esomeprazole, Clarithromycin, Amoxicillin, Bifidobacterium Bifidum Capsules) and Group D(Esomeprazole, Furazolidone, Amoxicillin, Bismuth Potassium Citrate Capsules and Bismuth Potassium Citrate Capsules), and Group D(Esomeprazole, Furazolidone, Bism Bifidobacterium triple viable capsule. The clinical remission effect, eradication efficiency of Hp, adverse reactions, recurrence and cost-effectiveness ratio of the four groups were analyzed and compared. Two bismuth-containing quadruple therapies combined with Bifid Triple Viable capsules were better than bismuth-containing quadruple therapies in alleviating clinical symptoms, eradication rat e of Helicobacter pylori, incidence of adverse reactions and recurrence in patients with Helicobacter pylori infection, but the cost-effectiveness of group D was better than that of bifide-containing quadruple therapies. Esomeprazole, furazolidone, amoxicillin, bismuth potassium citrate capsules and Bifidobacterium triple viable capsules can promote the recovery of patients with Hp, with high eradication rate, and reduce adverse reactions and recurrence rate. It has economic advantages and is worth popularizing and applying.
引文
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