脑血通对脑缺血的作用研究
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摘要
目的:研究脑血通对脑缺血病变的作用,为其在临床上的应用提供药理学依据。方法:运用大鼠局灶性永久脑缺血模型,大鼠局灶性脑缺血再灌注模型及高脂大鼠脑缺血再灌注模型,观察脑血通对实验性脑缺血模型的保护作用。结果:脑血通6.0g/kg可显著减少局灶性脑缺血大鼠的神经评分和大脑梗死面积,减轻局灶性脑缺血再灌注模型大鼠脑水肿程度,降低其神经系统评分;脑血通3.0g/kg和1.5g/kg可显著减少局灶性脑缺血大鼠大脑梗死面积;脑血通1.5g/kg、3.0g/kg、6.0g/kg均可显著降低脑缺血再灌注高脂大鼠TC水平,改善其血液流变学指标。结论 :脑血通能够减少脑缺血大鼠脑梗死比率,减轻脑水肿程度,改善神经系统症状,改善脑组织病理表现,调节脂代谢紊乱,对血液流变学异常有改善作用。
Objective: To investigate the effects of Naoxuetong emulsion on focal cerebral ischemia and ischemia-reperfusion. Methods: To study the protective effects of the Naoxuetong emulsion,rats were induced focal permanent ischemia,focal cerebral ischemia-reperfusion,or hyperlipidemic ischemia-reperfusion. Results: Naoxuetong emulsion 6. 0g / kg can decrease the neurological severity score and ratio of cerebral infarction in focal cerebral ischemia rats,improved the symptoms of nervous system and pathology in focal cerebral ischemia rats. It can decrease remarkably the ratio of cerebral edema and behavioral neurologic assessment score. Naoxuetong emulsion 3. 0g / kg and 1. 5g / kg can obviously decrease the ratio of cerebral infarction and cerebral edema and improve the symptoms of nervous system in focal cerebral ischemia rats. Naoxuetong emulsion 6. 0g / kg,3. 0g / kg and 1. 5g / kg can decrease remarkably the TC level and ameliorate the hemorrheologic indices in cerebral ischemia-reperfusion of hyperlipidemic rats. Conclusion: All the results showed above indicate that Naoxuetong emulsion has protective effect on the cerebral ischemic injuries. It may be related to decrease the ratio of cerebral edema and blood rheological property.
Objective: To investigate the effects of Naoxuetong emulsion on focal cerebral ischemia and ischemia-reperfusion. Methods: To study the protective effects of the Naoxuetong emulsion,rats were induced focal permanent ischemia,focal cerebral ischemia-reperfusion,or hyperlipidemic ischemia-reperfusion. Results: Naoxuetong emulsion 6. 0g / kg can decrease the neurological severity score and ratio of cerebral infarction in focal cerebral ischemia rats,improved the symptoms of nervous system and pathology in focal cerebral ischemia rats. It can decrease remarkably the ratio of cerebral edema and behavioral neurologic assessment score. Naoxuetong emulsion 3. 0g / kg and 1. 5g / kg can obviously decrease the ratio of cerebral infarction and cerebral edema and improve the symptoms of nervous system in focal cerebral ischemia rats. Naoxuetong emulsion 6. 0g / kg,3. 0g / kg and 1. 5g / kg can decrease remarkably the TC level and ameliorate the hemorrheologic indices in cerebral ischemia-reperfusion of hyperlipidemic rats. Conclusion: All the results showed above indicate that Naoxuetong emulsion has protective effect on the cerebral ischemic injuries. It may be related to decrease the ratio of cerebral edema and blood rheological property.
引文
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8 马雪瑛,王敏,林成仁,等.救心滴丸对血液流变性和血栓形成的影响.中药新药与临床药理,2002;13(6)∶366~368
2 高梅,杜冠华.抗脑缺血药物的研究现状与进展.中国医药导刊,2006(5)∶323~325
3 惠文.川芎对脑血管疾病的药理作用.开卷有益:求医问药,2012(1)∶31~31
4 盛艳梅,孟宪丽,李春雨,等.川芎挥发油对大鼠大脑皮层神经细胞体外存活及脑缺血再灌注损伤的影响.时珍国医国药,2012;23(3)∶536 ~538
5 李建生,李建国,赵君玫,等.川芎嗪和参麦注射液对老龄大鼠脑缺血-再灌注多器官损伤的作用.中国中西医结合急救杂志,2000;7(5)∶289~294
6 廖矛川,葛岚岚,陈锋,等.石菖蒲化学成分研究.中南民族大学学报(自然科学版),2011;30(4)∶45~47
7 韩亚亮,刘萍,何新荣,等.石菖蒲挥发油的基本成分及其药理作用研究进展.中国药物应用与监测,2011;8(2)∶120~124
8 马雪瑛,王敏,林成仁,等.救心滴丸对血液流变性和血栓形成的影响.中药新药与临床药理,2002;13(6)∶366~368