参芪柔脉合剂对颈动脉粥样硬化病人血脂、血清炎症因子及颈动脉内中膜厚度的影响
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摘要
目的探讨参芪柔脉合剂对颈动脉粥样硬化(CAS)病人血脂、血清炎症因子及颈动脉内中膜厚度(IMT)的影响。方法选取CAS病人87例,采用随机数字表法分为两组。对照组43例采用辛伐他汀胶囊治疗,观察组44例采用参芪柔脉合剂联合辛伐他汀治疗。比较两组血脂四项、炎症因子水平、IMT与颈动脉内膜斑块面积及不良反应发生情况。结果治疗3个月后,两组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IMT及颈动脉内膜斑块面积均较治疗前显著降低,高密度脂蛋白胆固醇(HDL-C)显著升高,差异有统计学意义(P<0.05);与对照组比较,观察组TC、TG、LDL-C、hs-CRP、TNF-α、IL-6、IMT及颈动脉内膜斑块面积均降低,HDL-C升高,差异有统计学意义(P<0.05)。结论参芪柔脉合剂联合辛伐他汀治疗能改善CAS病人血脂情况,并具有抗炎,稳定斑块作用。
Objective To investigate the effects of Shenqi Roumai formula(SRF) on blood lipids,serum inflammatory factors,and carotid intima-media thickness(IMT) in patients with carotid atherosclerosis(CAS).Methods Eighty-seven patients with CAS were randomly divided into two groups:the control group(43 cases) treated with simvastatin,and the obervation group(44 cases) treated with SRF plus simvastatin for 3 months.Blood lipid levels,inflammatory factors levels,IMT and carotid intima plaque area and adverse reactions were observed.Results After 3 months of treatment,the levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IMT,and carotid intima plaque area were significantly decreased,while HDL-C level was significantly increased,the difference was statistically significant(P<0.05).Compared with the control group,the levels of TC,TG,LDLC,hs-CRP,TNF-α,IL-6,IMT and carotid intima plaque area were decreased,and HDL-C level was increased,the difference was statistically significant(P<0.05 or P<0.01).Conclusion SRF can improve the blood lipids,anti-inflammation,and stabilize the plaque in patients with CAS.
Objective To investigate the effects of Shenqi Roumai formula(SRF) on blood lipids,serum inflammatory factors,and carotid intima-media thickness(IMT) in patients with carotid atherosclerosis(CAS).Methods Eighty-seven patients with CAS were randomly divided into two groups:the control group(43 cases) treated with simvastatin,and the obervation group(44 cases) treated with SRF plus simvastatin for 3 months.Blood lipid levels,inflammatory factors levels,IMT and carotid intima plaque area and adverse reactions were observed.Results After 3 months of treatment,the levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IMT,and carotid intima plaque area were significantly decreased,while HDL-C level was significantly increased,the difference was statistically significant(P<0.05).Compared with the control group,the levels of TC,TG,LDLC,hs-CRP,TNF-α,IL-6,IMT and carotid intima plaque area were decreased,and HDL-C level was increased,the difference was statistically significant(P<0.05 or P<0.01).Conclusion SRF can improve the blood lipids,anti-inflammation,and stabilize the plaque in patients with CAS.
引文
[1] ROSS R.Atherosclerosis-an inflammatory disease[J].N Eng J Med,1999,340(2):115-126.
[2] 胡翠平,宋智慧,王勇.参芪柔脉合剂对实验兔颈动脉粥样斑块的影响[J].湖南中医杂志,2017,33(5):164-166.
[3] 周永昌,郭万学.超声医学[M].6版.北京:人民军医出版社,2012:689.
[4] 刘婷婷.脑心通联合阿托伐他汀治疗脑梗死颈动脉粥样硬化患者的疗效[J].中国老年学杂志,2012,2(32):494-495.
[5] 张艳,宫丽鸿,礼海.浅谈动脉粥样硬化的病因病机[J].时珍国医国药,2010,21(5):1125-1126.
[6] 郝菲,刘雅,李晓辉.三七皂苷对apoE小鼠骨髓微循环中干细胞因子的影响[J].中药药理与临床,2013,29(2):26-29.
[7] 职玉娟,黄水清.黄芪、当归药对及当归补血汤对小鼠巨噬细胞吞噬氧化低密度脂蛋白的作用[J].广州中医药大学学报,2013,30(2):200-202.
[8] 冯宗忱.动脉粥样硬化——血管壁的慢性炎症[J].中华心血管病杂志,2005,33(5):393-394.
[9] LORENZ M W,MARKUS H S,BOTS M L,et al.Predition of clinical cardiovascular events with carotid intima-media thickness:a systematic review and meta-analysis[J].Circulation,2007,115(8):459 -467.
[10] RAHMAN S H,MENON K V,HOLMFIELD J H,et al.Serum macrophage migration inhibitory factor is an early maker of pancreatic necrosis in acute pancreatitis[J].Ann Surg ,2007,245(2):282-289.
[11] GOLD L I,SUNG J J,SIEBERT J W,et al.TypeⅠ (RⅠ) and typeⅡ(RⅡ) receptors for transforming growth facter-b informs expressed subsequent to transforming growth facter-b during exercisional wound repair[J].Am J Pathol,1997,150:209-214.
[2] 胡翠平,宋智慧,王勇.参芪柔脉合剂对实验兔颈动脉粥样斑块的影响[J].湖南中医杂志,2017,33(5):164-166.
[3] 周永昌,郭万学.超声医学[M].6版.北京:人民军医出版社,2012:689.
[4] 刘婷婷.脑心通联合阿托伐他汀治疗脑梗死颈动脉粥样硬化患者的疗效[J].中国老年学杂志,2012,2(32):494-495.
[5] 张艳,宫丽鸿,礼海.浅谈动脉粥样硬化的病因病机[J].时珍国医国药,2010,21(5):1125-1126.
[6] 郝菲,刘雅,李晓辉.三七皂苷对apoE小鼠骨髓微循环中干细胞因子的影响[J].中药药理与临床,2013,29(2):26-29.
[7] 职玉娟,黄水清.黄芪、当归药对及当归补血汤对小鼠巨噬细胞吞噬氧化低密度脂蛋白的作用[J].广州中医药大学学报,2013,30(2):200-202.
[8] 冯宗忱.动脉粥样硬化——血管壁的慢性炎症[J].中华心血管病杂志,2005,33(5):393-394.
[9] LORENZ M W,MARKUS H S,BOTS M L,et al.Predition of clinical cardiovascular events with carotid intima-media thickness:a systematic review and meta-analysis[J].Circulation,2007,115(8):459 -467.
[10] RAHMAN S H,MENON K V,HOLMFIELD J H,et al.Serum macrophage migration inhibitory factor is an early maker of pancreatic necrosis in acute pancreatitis[J].Ann Surg ,2007,245(2):282-289.
[11] GOLD L I,SUNG J J,SIEBERT J W,et al.TypeⅠ (RⅠ) and typeⅡ(RⅡ) receptors for transforming growth facter-b informs expressed subsequent to transforming growth facter-b during exercisional wound repair[J].Am J Pathol,1997,150:209-214.