白细胞介素-6、降钙素原、C反应蛋白、APACHE Ⅱ评分在ICU重症感染患者中的诊断价值
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摘要
目的探讨白细胞介素-6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分在ICU重症感染患者中的诊断价值。方法选取在ICU病房住院的130例患者作为研究对象,将76例重症感染患者设为研究组,另54例非感染患者设为对照组,比较2组患者的实验室指标结果。结果研究组患者的IL-6、PCT、CRP水平显著高于对照组患者(P <0. 05);研究组患者的APACHEⅡ评分结果与对照组相比,差异有统计学意义(P <0. 05)。结论血清IL-6、PCT、CRP在ICU重症感染患者的感染诊断中具有较好的灵敏度,上述指标联合APACHEⅡ评分在评估患者病情严重程度及感染程度方面具有较高的准确性。
Objective To explore value of interleukin-6( IL-6),procalcitonin( PCT),C-reactive protein( CRP),and acute physiology and chronic health evaluationⅡ( APACHEⅡ) score in diagnosis of severe infection in ICU. Methods A total of 130 ICU hospitalized patients in our hospital were selected as study subjects,among whom 76 patients with severe infections were selected as study group and 54 non-infectious patients were as control group. The results of laboratory indexes of the two groups were analyzed and compared. Results The levels of IL-6,PCT and CRP in the study group were significantly higher than that in the control group( P < 0. 05). The APACHE Ⅱ score of the two groups showed no significant difference( P < 0. 05). Conclusion Serum IL-6,PCT and CRP have good sensitivity in the diagnosis of infection in ICU patients with severe infection. APACHE Ⅱscore combined with above indicators has higher accuracy in the evaluation of severity and infection.
Objective To explore value of interleukin-6( IL-6),procalcitonin( PCT),C-reactive protein( CRP),and acute physiology and chronic health evaluationⅡ( APACHEⅡ) score in diagnosis of severe infection in ICU. Methods A total of 130 ICU hospitalized patients in our hospital were selected as study subjects,among whom 76 patients with severe infections were selected as study group and 54 non-infectious patients were as control group. The results of laboratory indexes of the two groups were analyzed and compared. Results The levels of IL-6,PCT and CRP in the study group were significantly higher than that in the control group( P < 0. 05). The APACHE Ⅱ score of the two groups showed no significant difference( P < 0. 05). Conclusion Serum IL-6,PCT and CRP have good sensitivity in the diagnosis of infection in ICU patients with severe infection. APACHE Ⅱscore combined with above indicators has higher accuracy in the evaluation of severity and infection.
引文
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[2]田建华,张新枝,王洪,等.血清PCT和CRP及D-D水平与危重症感染患者IPS评分的关系[J].中华医院感染学杂志,2018,28(19):2910-2913.
[3]余玺,张珊珊,周晓欢,等.血清PCT、hs-CRP及PA在老年肺部感染患者中的临床诊断价值[J].基因组学与应用生物学,2018,37(9):4076-4081.
[4]魏志明,许勤,张志刚.呼吸重症监护病房多药耐药菌定植与感染的临床鉴定分析[J].中国病原生物学杂志,2018,13(8):903-906.
[5]袁盛伟,邓杰.CRP、PCT与APACHEⅡ评分判断ICU老年重症感染患者预后的价值[J].中国老年学杂志,2018,38(7):1655-1657.
[6]李锦春,戴梅,刘荣,等.外周血炎症介质对重症急性胰腺炎继发肺部感染的辅助诊断价值[J].辽宁中医杂志,2017,44(8):1686-1688.
[7]亓俊杰,刘建花,周凡,等.血清降钙素原危急值与血清炎性指标检测在心血管内科感染重症患者的临床意义[J].中华医院感染学杂志,2017,27(5):992-995.
[8]孙明华.不同感染状态下的儿童PCT及hs-CRP的临床研究[J].中国地方病防治杂志,2016,31(7):833-835.
[9]李诗阳,王日兴,吕有凯,等.老年重症感染患者血清降钙素原与C-反应蛋白联合检测的临床价值[J].中国老年学杂志,2016,36(8):1960-1961.
[10]皮白雉,方强,姚小英,等.重症细菌感染患者血清降钙素原联合C-反应蛋白水平检测的应用研究[J].中华医院感染学杂志,2016,26(8):1718-1720.