银杏二萜内酯葡胺对非致残性轻型卒中患者的血流变及预后影响
|
摘要
目的探讨银杏二萜内酯葡胺注射液对非致残性轻型卒中患者的血流变及预后影响。方法收集本院117例起病两周内的非致残性轻型卒中患者,随机分为治疗组和对照组,使用美国国立卫生研究院卒中量表(NIHSS)对入组患者分阶段评分,用日常生活能力评定量表(Barthel指数)进行评估。对照组采用阿司匹林肠溶片100mg/日及阿托伐他汀钙片20mg/日及丁苯酞注射液等药物治疗,治疗组在对照组基础上加银杏二萜内酯葡胺注射液治疗,均分别于治疗前及治疗2周后进行血液流变学检测,观察对比两组患者的神经功能损伤程度及日常生活能力评分。结果治疗组患者NIHSS评分明显低于对照组;Barthel指数明显高于对照组;血液流变学改善显著优于对照组,差异显著均有统计学意义(P <0.05)。结论银杏二萜内酯葡胺注射液可改善非致残性轻型卒中患者的血液流变学指标,并显著降低其神经损伤程度及提高日常生活能力(ADL)。
Objective To investigate the effect of ginkgo diterpene lactone glucamine injection on hemorheology and prognosis in patients with non-disabling mild stroke. Methods Collecting 117 patients with non-disabling mild stroke within two weeks of onset in our hospital and random Ly dividing them into treatment group and control group. Grading the patients in stages by using the National Institutes of Health Stroke Scale(NIHSS) and making assessment by using the Daily Living Ability Rating Scale(Barthel Index).The control group was treated with aspirin enteric-coated tablets 100 mg/day and atorvastatin calcium tablets 20 mg/day and butylphthalide injection. While the treatment group was treated with ginkgo diterpene lactide and glucamine injection on the basis of the control group. All patients were tested for hemorheology before treatment and 2 weeks after treatment. Observing the degree of neurological impairment and the ability of daily living ability of the two groups of patients. Results The NIHSS score of the treatment group was significantly lower than that of the control group, Barthel index was significantly higher than the control group and hemorheological improvement was significantly better than the control group(P < 0.05). Conclusion Ginkgo biloba lactone glucamine injection can improve the blood rheology index of non-disabling mild stroke patients, and significantly reduce the degree of nerve damage and improve daily living ability(ADL).
Objective To investigate the effect of ginkgo diterpene lactone glucamine injection on hemorheology and prognosis in patients with non-disabling mild stroke. Methods Collecting 117 patients with non-disabling mild stroke within two weeks of onset in our hospital and random Ly dividing them into treatment group and control group. Grading the patients in stages by using the National Institutes of Health Stroke Scale(NIHSS) and making assessment by using the Daily Living Ability Rating Scale(Barthel Index).The control group was treated with aspirin enteric-coated tablets 100 mg/day and atorvastatin calcium tablets 20 mg/day and butylphthalide injection. While the treatment group was treated with ginkgo diterpene lactide and glucamine injection on the basis of the control group. All patients were tested for hemorheology before treatment and 2 weeks after treatment. Observing the degree of neurological impairment and the ability of daily living ability of the two groups of patients. Results The NIHSS score of the treatment group was significantly lower than that of the control group, Barthel index was significantly higher than the control group and hemorheological improvement was significantly better than the control group(P < 0.05). Conclusion Ginkgo biloba lactone glucamine injection can improve the blood rheology index of non-disabling mild stroke patients, and significantly reduce the degree of nerve damage and improve daily living ability(ADL).
引文
[1]王光胜,耿德勤.脑缺血/再灌注损伤机制研究进展[J].医学综述,2016,17(24):3753-3756.
[2]中华医学会.全国第四届脑血管学术会议各类脑血管病的诊断标准[J].中华神经科杂志,1996,29(6):379-381.
[3]刘秋,许治良,周军等.银杏二萜内酯葡胺注射液对缺糖缺氧损伤的SH-SY5Y细胞保护作用[J].《中国药理学通报》,2015,9(7):994-999.
[4]刘新生,陈江波,徐海芳等.脑脉泰胶囊对急性脑梗死患者预后的影响[J].中国医刊,2014,(10):58-60.
[5]康康,冀书娟等.通络救脑注射液对大鼠脑缺血/再灌注神经保护作用的研究.中国实用神经疾病杂志,2016,19(5):57-59.
[6]陈谦,郑良成,杨曌.阿托伐他汀调脂治疗对急性脑梗死患者血清超敏C反应蛋白白细胞介素-17及基质金属蛋白酶-8的影响[J].中国实用神经疾病杂志,2015,10(3):9-11.
[7]K.S.Wong,L.R.Caplan and J.S.Kim.Stroke Mechanisms[J].Front Neurol Neurosci,2016,(40):58-71.
[8]陈春苗,周军等.银杏二萜内酯葡胺注射液对大鼠急性脑缺血再灌注损伤的影响.中国实验方剂学杂志.2014,17(4):133-136.
[9]姜丹,张乐,马军等.银杏叶注射液对脑缺血再灌注大鼠脑组织琥珀酸脱氢酶和肌酸激酶脑型同工酶活性的影响[J].中国临床保健杂志,2010,13(4):389-391.
[10]吴常青,汪春彦,董六一等.补阳还五汤有效部位对大鼠局灶性脑缺血再灌注损伤的保护作用及机制[J].中草药,2016(01):114-117.
[11]金治全,许治良,刘秋等.银杏二萜内酯葡胺注射液通过激活Akt/Nrf2通路抑制缺糖缺氧诱导的SH-SY5Y细胞的氧化应激损伤[J].《中国药理学与毒理学杂志》,2017,31(1):65-72
[12]罗燕平,张红,胡晗绯等.银杏二萜内酯葡胺注射液对大鼠局灶性脑缺血的保护作用[J].《中国中药杂志》,2017,(24):4733-4737.
[13]章晨峰,曹亮等.银杏二萜内酯葡胺注射液对脑缺血再灌注大鼠行为学和脑脊液成分的影响[J].《中国实验方剂学杂志》,2015,(20):118-122.
[14]陶晓倩,曹泽彧等.银杏二萜内酯K抗血小板聚集及神经保护作用研究[J].《中国中药杂志》,2017,(24):4727-4732.
[15]张雯,宋俊科等.银杏二萜内酯对大鼠脑缺血/再灌注损伤的保护作用及机制研究[J].《中国药理学通报》,2015,(11):207-208.
[16]仲崇金,华骏等.银杏二萜内酯葡胺注射液对缺血性脑卒中急性期损伤的保护作用[J].《药物评价研究》,2017,40(6):752-758.
[17]徐君,王奎龙等.银杏二萜内酯类化合物拮抗PAF诱导的血小板聚集及对神经细胞的保护作用[J].《中国中药杂志》,2017,(24):4716-4721.
[18]王立英,杨世杰.脑缺血-再灌注损伤机制及其药物治疗方法的研究进展[J].吉林大学学报,2016,38(6):1227-1231.
[2]中华医学会.全国第四届脑血管学术会议各类脑血管病的诊断标准[J].中华神经科杂志,1996,29(6):379-381.
[3]刘秋,许治良,周军等.银杏二萜内酯葡胺注射液对缺糖缺氧损伤的SH-SY5Y细胞保护作用[J].《中国药理学通报》,2015,9(7):994-999.
[4]刘新生,陈江波,徐海芳等.脑脉泰胶囊对急性脑梗死患者预后的影响[J].中国医刊,2014,(10):58-60.
[5]康康,冀书娟等.通络救脑注射液对大鼠脑缺血/再灌注神经保护作用的研究.中国实用神经疾病杂志,2016,19(5):57-59.
[6]陈谦,郑良成,杨曌.阿托伐他汀调脂治疗对急性脑梗死患者血清超敏C反应蛋白白细胞介素-17及基质金属蛋白酶-8的影响[J].中国实用神经疾病杂志,2015,10(3):9-11.
[7]K.S.Wong,L.R.Caplan and J.S.Kim.Stroke Mechanisms[J].Front Neurol Neurosci,2016,(40):58-71.
[8]陈春苗,周军等.银杏二萜内酯葡胺注射液对大鼠急性脑缺血再灌注损伤的影响.中国实验方剂学杂志.2014,17(4):133-136.
[9]姜丹,张乐,马军等.银杏叶注射液对脑缺血再灌注大鼠脑组织琥珀酸脱氢酶和肌酸激酶脑型同工酶活性的影响[J].中国临床保健杂志,2010,13(4):389-391.
[10]吴常青,汪春彦,董六一等.补阳还五汤有效部位对大鼠局灶性脑缺血再灌注损伤的保护作用及机制[J].中草药,2016(01):114-117.
[11]金治全,许治良,刘秋等.银杏二萜内酯葡胺注射液通过激活Akt/Nrf2通路抑制缺糖缺氧诱导的SH-SY5Y细胞的氧化应激损伤[J].《中国药理学与毒理学杂志》,2017,31(1):65-72
[12]罗燕平,张红,胡晗绯等.银杏二萜内酯葡胺注射液对大鼠局灶性脑缺血的保护作用[J].《中国中药杂志》,2017,(24):4733-4737.
[13]章晨峰,曹亮等.银杏二萜内酯葡胺注射液对脑缺血再灌注大鼠行为学和脑脊液成分的影响[J].《中国实验方剂学杂志》,2015,(20):118-122.
[14]陶晓倩,曹泽彧等.银杏二萜内酯K抗血小板聚集及神经保护作用研究[J].《中国中药杂志》,2017,(24):4727-4732.
[15]张雯,宋俊科等.银杏二萜内酯对大鼠脑缺血/再灌注损伤的保护作用及机制研究[J].《中国药理学通报》,2015,(11):207-208.
[16]仲崇金,华骏等.银杏二萜内酯葡胺注射液对缺血性脑卒中急性期损伤的保护作用[J].《药物评价研究》,2017,40(6):752-758.
[17]徐君,王奎龙等.银杏二萜内酯类化合物拮抗PAF诱导的血小板聚集及对神经细胞的保护作用[J].《中国中药杂志》,2017,(24):4716-4721.
[18]王立英,杨世杰.脑缺血-再灌注损伤机制及其药物治疗方法的研究进展[J].吉林大学学报,2016,38(6):1227-1231.