水降解对聚乳酸长丝质量和强度的影响
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摘要
在不同温度、p H值的去离子水环境条件下,分析聚乳酸(PLA)长丝的质量降解率随时间的变化,并模拟人体体液环境,研究了PLA长丝在磷酸盐缓冲液(PBS溶液)中的质量和强度的变化规律。结果表明:随着去离子水温度的升高,PLA长丝的质量降解率先增大后小幅减小;在去离子水中,酸性抑制PLA长丝的降解,碱性促进其降解,当p H值大于11时,PLA长丝的降解非常明显;在模拟人体体液环境的PBS溶液中,PLA长丝初期质量降解率很小,降解速率增幅缓慢,降解时间大于20 d后,PLA长丝的质量降解率和降解速率都大幅增加,降解60 d时,PLA长丝的断裂强度下降了36.9%,断裂伸长率提高了37.8%,初始模量先增大后减小。
The change of the mass degradation rate of polylactic acid( PLA) filament with time was analyzed in deionized water with different p H value at different temperatures. The change regularity of the mass and strength of PLA filament was studied by simulating human body fluid with phosphate buffer( PBS solution). The results showed that the mass degradation rate of PLA filament was increased and then slightly decreased with the elevation of deionized water temperature; acid deionized water inhibited the degradation of PLA when alkali deionized water promoted the degradation; the degradation of PLA filament was profoundly enhanced when the p H value of deionized water was above 11; the mass degradation rate of PLA filament was low initially and then increased slowly in PBS solution simulating human body fluid; the mass degradation rate and degradation rate both considerably increased as the degradation time was longer than 20 d; and the breaking strength of PLA filament was decreased by 36. 9%,the elongation at break was increased by 37. 8% and the initial modulus was increased and then decreased as the degradation time was 60 d.
The change of the mass degradation rate of polylactic acid( PLA) filament with time was analyzed in deionized water with different p H value at different temperatures. The change regularity of the mass and strength of PLA filament was studied by simulating human body fluid with phosphate buffer( PBS solution). The results showed that the mass degradation rate of PLA filament was increased and then slightly decreased with the elevation of deionized water temperature; acid deionized water inhibited the degradation of PLA when alkali deionized water promoted the degradation; the degradation of PLA filament was profoundly enhanced when the p H value of deionized water was above 11; the mass degradation rate of PLA filament was low initially and then increased slowly in PBS solution simulating human body fluid; the mass degradation rate and degradation rate both considerably increased as the degradation time was longer than 20 d; and the breaking strength of PLA filament was decreased by 36. 9%,the elongation at break was increased by 37. 8% and the initial modulus was increased and then decreased as the degradation time was 60 d.
引文
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[13]吴双全,张佩华,郭正.不同比例PGA/PLA编织线的体外降解性能[J].东华大学学报:自然科学版,2009,6(3):274-278.
[2]舒晓军,杨青芳,杜江华,等.聚乳酸的改性及应用[J].合成纤维工业,2006,29(6):45-47.
[3]Madhavan Nampoothiri K,Nair N R,John R P.An overview of the recent developments in polylactide(PLA)research[J].Bioresource Technol,2010,101(22):8493-8501.
[4]李佳,郑卫,郑玉峰.医用聚乳酸材料的化学改性研究进展[J].材料导报,2009,23(8):49-53.
[5]Scapin S M N,Silvan D R M,Joazeiro P P,et al.Use of triethylcitrate plasticizer in the production of poly-L-lactic acid implants with different degradation times[J].J Mater Sci:Mater Med,2003,14(7):635-640.
[6]杨美娟,薛平.聚乳酸生物复合材料降解性能的研究[J].当代化工,2010,39(4):353-356.
[7]叶伟,汪章婉,周文龙.中性缓冲盐的添加对聚乳酸降解性能的影响[J].浙江理工大学学报,2010,27(2):198-202.
[8]朱莉芳.聚乳酸的合成及降解机理[J].生物骨科材料与临床研究,2006(2):42-47.
[9]钱以宏.聚乳酸酯及其降解特性[J].纺织导报,2004(4):38-40.
[10]张敏,崔春娜.聚乳酸降解的影响因素和降解机理的分析[J].包装工程,2008,29(8):16-18.
[11]董奇伟.聚乳酸降解性能研究进展[J].塑料制造,2011(3):66-69.
[12]刘磊,吴若峰.聚乳酸类材料的水解特征[J].合成材料老化与应用,2006,35(1):44-48.
[13]吴双全,张佩华,郭正.不同比例PGA/PLA编织线的体外降解性能[J].东华大学学报:自然科学版,2009,6(3):274-278.