食管癌患者血清NGAL、Hcy、sTNF-RI、白介素及食管动力学指标的变化观察
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摘要
目的分析食管癌患者的血清NGAL、Hcy、sTNF-RI、白介素及食管动力学指标的变化情况。方法选取本院收治的66例食管癌患者为观察组,并选取同时间段的66名体检健康人员为对照组,然后将2组的血清NGAL、Hcy、sTNF-RI、白介素及食管动力学指标进行检测与比较,然后将观察组中不同食管癌分期者的检测指标进行比较。结果观察组的血清IL-2低于对照组,血清NGAL、Hcy、sTNF-RI及IL-6、IL-8、IL-18则均高于对照组,另外食管收缩压、蠕动性收缩比及食管括约肌松弛率低于对照组,且观察组中食管癌分期较高者的变化大于食管癌分期较低的患者,差异均有统计学意义(P<0.05)。结论食管癌患者的血清NGAL、Hcy、sTNF-RI、白介素及食管动力学指标呈现异常的状态,且其检测水平受疾病分期的影响较大。
Objective To observe and analyze the changes of serum NGAL,Hcy,sTNFRI,interleukin levels and esophageal dynamics indexes of patients with esophageal cancer. Methods A total of 66 patients with esophageal cancer in our hospital were selected as observation group,another 66 healthy persons with health examination at the same period were selected as control group,then the serum NGAL,Hcy,sTNF-RI,interleukin levels and esophageal dynamics indexes of two groups were detected and compared,and the indexes of observation group with different stages of esophageal cancer were compared. ResultsThe serum IL-2 of observation group was lower than that of control group,serum NGAL,Hcy,sTNF-RI and IL-6,IL-8,IL-18 levels were all higher than that of control group,and esophageal pressure,peristaltic contraction ratio and esophageal sphincter relax rate were all lower than that of control group,and the changes of those indexes of observation group with higher stage of esophageal cancer were more than that of patients with lower stage of esophageal cancer( P < 0. 05). Conclusion The serum NGAL,Hcy,sTNF-RI,interleukin levels and esophageal dynamics indexes of patients with esophageal cancer show abnormal state,and the influence of disease stages for the detection levels are great.
Objective To observe and analyze the changes of serum NGAL,Hcy,sTNFRI,interleukin levels and esophageal dynamics indexes of patients with esophageal cancer. Methods A total of 66 patients with esophageal cancer in our hospital were selected as observation group,another 66 healthy persons with health examination at the same period were selected as control group,then the serum NGAL,Hcy,sTNF-RI,interleukin levels and esophageal dynamics indexes of two groups were detected and compared,and the indexes of observation group with different stages of esophageal cancer were compared. ResultsThe serum IL-2 of observation group was lower than that of control group,serum NGAL,Hcy,sTNF-RI and IL-6,IL-8,IL-18 levels were all higher than that of control group,and esophageal pressure,peristaltic contraction ratio and esophageal sphincter relax rate were all lower than that of control group,and the changes of those indexes of observation group with higher stage of esophageal cancer were more than that of patients with lower stage of esophageal cancer( P < 0. 05). Conclusion The serum NGAL,Hcy,sTNF-RI,interleukin levels and esophageal dynamics indexes of patients with esophageal cancer show abnormal state,and the influence of disease stages for the detection levels are great.
引文
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[11]郑勇,姚元波,蔡彦力,等.胸腔镜食管癌根治术与开放食管癌根治术对患者围手术期免疫功能、应激反应的影响[J].海南医学院学报,2016,22(20):2434-2436.
[12]陈勃,董忠谊,曹传辉,等.蛋白激酶CK2β在食管癌中的表达及其临床意义[J].南方医科大学学报,2012,32(10):1491-1494.
[13]吴勇,余南彬.食管癌患者血浆及肿瘤组织中核黄素含量检测及其临床病理意义评估[J].海南医学院学报,2016,22(12):1307-1310.
[2]刘红旗,张绍岚,宋曙,等.食管癌患者的血清白细胞介素和急性时相反应蛋白含量变化研究[J].现代生物医学进展,2012,12(34):6737-6739.
[3]陈芸,韩存芝,张双平,等.食管癌患者手术前后血清同型半胱氨酸水平检测的临床意义[J].肿瘤研究与临床,2012,(12):825-827,830.
[4]邱社祥,毛跃,蔡辉华,等.黏膜瓣式食管胃吻合术抗反流的食管动力学研究[J].中华胃肠外科杂志,2005,8(3):196-198.
[5]Makuuchi Y,Honda K,Osaka Y,et al.Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy[J].Cancer Sci,2013,104(8):1045-1051.
[6]夏国浩,陆红霞.食管癌患者手术治疗前后血清IL-2、IFN-γ、IL-4和IL-10检测的临床意义[J].放射免疫学杂志,2012,25(5):600-602.
[7]肖友阳,刘敏,杜开南.食管癌患者血清IL-18水平及手术对其影响的临床研究[J].中国现代药物应用,2012,6(12):9-10.
[8]Babar M,Ryan A W,Anderson L A,et al.Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus andesophageal adenocarcinoma[J].Am J Gastroenterol,2012,107(9):1331-1341.
[9]何炳虹,陈光辉,潘引鹏.食管癌患者手术治疗前后血清Hcy、IGF-Ⅱ和TSGF检测的临床意义[J].放射免疫学杂志,2010,23(5):491-492.
[10]何海明,祝峰,施根林,等.食管癌患者手术前后血浆Hcy和血清FA、维生素B12含量检测及其临床意义[J].武警医学,2010,21(6):481-482,485.
[11]郑勇,姚元波,蔡彦力,等.胸腔镜食管癌根治术与开放食管癌根治术对患者围手术期免疫功能、应激反应的影响[J].海南医学院学报,2016,22(20):2434-2436.
[12]陈勃,董忠谊,曹传辉,等.蛋白激酶CK2β在食管癌中的表达及其临床意义[J].南方医科大学学报,2012,32(10):1491-1494.
[13]吴勇,余南彬.食管癌患者血浆及肿瘤组织中核黄素含量检测及其临床病理意义评估[J].海南医学院学报,2016,22(12):1307-1310.