子宫内膜异位症恶变的临床研究进展
摘要
子宫内膜异位症(EMs)是育龄期妇女的常见病,由具有生长功能的异位子宫内膜所致,发病率可达10%~15%,异位内膜可侵犯全身任何部位,大多为良性,但也会出现恶性病变,其恶变率较低,临床容易误诊。本文从EMs恶变的发病率、发病原因、发病机制和临床特征等几个方面对其作一综述。
引文
[1]李慧.12例恶变的卵巢子宫内膜异位囊肿临床病理分析[D].大连:大连医科大学,2013.
[2]孙莉,肖喜荣,李斌.子宫内膜异位症(EM)瘤变23例分析[J].复旦学报(医学版),2013,40(4):468-471.doi:10.3969/j.issn.1672-8467.2013.04.018.
[3]Kadan Y,Fiascone S,Me Court C,et al.Predictive factors for the presence of malignant transformation of pelvic endometriosis[J].Eur J Obstet Gynecol Reprod Biol,2015,185(2):23-27.doi:10.1016/j.ejogrb.2014.11.029.
[4]Gadducci A,Lanfredini N,Tana R.Novel insights on the malignant transformation of endometriosis into ovarian carcinoma[J].Gynecol Endocrinol,2014,30(9):612-617.doi:10.3109/09513590.2014.926325.
[5]付晨薇,郎景和,沈铿,等.子宫内膜异位症合并卵巢恶性肿瘤的临床特点[J].协和医学杂志,2012,3(2):204-207.doi:10.3969/j.issn.1674-9081.2012.02.016.
[6]慕小燕.bcl-2、PIEN在卵巢子宫内膜异位症癌变过程中的作用观察[J].社区医学杂志,2009,7(15):3-4.
[7]Samartzis E P,Samartzis N,Noske A,et al.Loss of ARID1A/BAF-250a-expression in endometriosis:a biomarker for risk of carcinogenic transformation?[J].Mod Pathol,2012,25(6):885-892.doi:10.1038/modpathol.2011.217.
[8]叶霞,王丽宏,郭志杰.PIEN及p16蛋白表达变化对卵巢子宫内膜异位症癌变的影响[J].中国临床实用医学,2014,5(5):46-47.doi:10.3760/cma.j.issn.1673-8799.2014.05.017.
[9]董春鸽,林雅,章杰,等.基质金属蛋白酶-9及抑癌基因PIEN在子宫内膜异位症中的表达及意义[J].浙江医学,2015,37(23):1913-1915.
[10]蒋苹,许红,王中弥,等.PIEN、Survivin蛋白在子宫内膜异位症相关的卵巢癌组织中表达的相关性及临床意义[J].中国实用医药,2014,15:3-6.
[11]Ma X,Hui Y,Lin L,et al.Possible relevance of tumor-related genes mutation to malignant transformation of endometriosis[J].European Journal Of Gynaecological Oncology,2016,37(1):89-94.
[12]王丽宏,叶霞,吕家峰.卵巢子宫内膜异位症恶性变过程中p53蛋白的表达变化[J].基层医学论坛,2015,33:4614-4616.
[13]姜晓凤,张颐,庞晓燕,等.子宫内膜异位症相关卵巢癌的临床分析[J].中国医科大学学报,2015,1:30-33.doi:10.3969/j.issn.0258-4646.2015.01.007.
[14]庞淑洁,郭冬辉.非典型子宫内膜异位症的免疫标记与恶变潜能[J].医学理论与实践,2014,27(15):1975-1977.
[15]Lin K,Zhan H,Ma J,et al.Increased steroid receptor RNA activator protein(SRAP)accompanied by decreased estrogen receptor-beta(ER-β)levels during the malignant transformation of endometriosis associated ovarian clear cell carcinoma[J].Acta Histochem,2014,116(5):878-882.doi:10.1016/j.acthis.2014.02.007.
[16]Guo C,Ren F,Wang D,et al.RUNX3 is inactivated by promoter hypermethylation in malignant transformation of ovarian endometriosis[J].OncolRep,2014,32(6):2580-2588.doi;10.3892/or.2014.3524.
[17]张颖,王庆一,梁艳红,等.p53、pl6、PIEN、hMLHl蛋白表达与卵巢子宫内膜异位症癌变的关系[J].新医学,2010,41(6):379-382.doi:10.3969/j.issn.0253-9802.2010.06.009.
[18]王成鑫,周红艳,黄萱,等.PIEN.EGFR和GH在子宫内膜异位症和异位恶变内膜中的表达及意义[J].江汉大学学报(自然科学版),2013,41(5):81-85.doi:10.3969/j.issn.1673-0143.2013.05.017.
[19]Dong M,Yang P,Hua F.MiR-191 modulates malignant transformation of endometriosis through regulating TIMP3[J].Med SciMonit,2015,21:915-920.doi:10.12659/MSM.893872.
[20]Tian X,Xu L,Wang P.MiR-191 inhibits TNF-a induced apopto sis of ovarian endometriosis and endometrioid carcinoma cells by targeting DAPK1[J].International Journal Of Clinical And Experimental Pathology,2015,8(5):4933-4942.
[21]Er T K,Su Y F,Wu C C,et al.Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer[J].Journal Of Molecular Medicine(Berlin,Germany),2016,94(7):835-847.doi:10.1007/s00109-016-1395-2.
[22]Anglesio M S,Bashashati A,Wang Y K,et aL Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden[J].The Journal Of Pathology,2015,236(2):201-209.doi:10.1002/path.4516.
[23]沈杨,刘娟,任慕兰.二噁英对小鼠异位子宫内膜影响的分子机制研究[J].中山大学学报(医学科学版),2010,31(5):608-613.
[24]刘娟,任慕兰.二噁英对小鼠异位子宫内膜中IL-1β表达的影响[J].中国妇幼健康研究,2011,22(2):162-164.doi:10.3969/j.issn.1673-5293.2011.02.015.
[25]李佳璘.上皮性卵巢癌合并子宫内膜异位症患者的临床、病理及预后特点[D].大连:大连医科大学,2014.
[26]邹海琼,柴艳婷.卵巢子宫内膜样癌及其合并子宫内膜异位症的临床及病理分析[J].现代中西医结合杂志,2014,5:540-541.doi:10.3969/j.issn.1008-8849.2014.05.037.
[27]张洁,欧阳艳红.卵巢子宫内膜样癌的病因分析及临床特点[J].临床合理用药,2014,7(9):113-114.doi:10.3969/j.issn.1674-3296.2014.27.081.
[28]王琪.围绝经期子宫腺肌病合并子宫内膜癌病例报告并文献复习[D].济南:山东大学,2014.
[29]武艳霞,刘晴,李全荣,等.子宫腺肌病恶变3例临床病理分析[J].现代肿瘤医学,2011,19(9):1834-1838.doi:10.3969/j.issn.1672-4992.2211.09.46.
[30]王力夫,孔令非.子宫腺肌病恶变8例临床病理分析[J].临床与实验病理学杂志,2011,27(3):330-333.doi:10.3969/j.issn.1001-7399.2011.03.033.
[31]李珍玲,金仁顺.卵巢子宫内膜异位症合并卵巢子宫内膜样肿瘤临床病理分析及文献复习[J].现代肿瘤医学,2014,22(9):2177-2179.doi:10.3969/j.issn.1672-4992.2014.09.54.
[32]Tanase Y,Furukawa N,Kobayashi H,et aL Malignant Transformation from Endometriosis to Atypical Endometriosis and Finally to Endometrioid Adenocarcinoma within 10 Years[J].Case Rep Oncol,2013,6(3):480-484.doi:10.1159/000355282.
[33]宋建平.子宫内膜异位症与卵巢癌相关性临床分析[J].现代肿瘤医学,2015,23(10):1432-1434.doi:10.3969/j.issn.1672-4992.2015.10.32.
[2]孙莉,肖喜荣,李斌.子宫内膜异位症(EM)瘤变23例分析[J].复旦学报(医学版),2013,40(4):468-471.doi:10.3969/j.issn.1672-8467.2013.04.018.
[3]Kadan Y,Fiascone S,Me Court C,et al.Predictive factors for the presence of malignant transformation of pelvic endometriosis[J].Eur J Obstet Gynecol Reprod Biol,2015,185(2):23-27.doi:10.1016/j.ejogrb.2014.11.029.
[4]Gadducci A,Lanfredini N,Tana R.Novel insights on the malignant transformation of endometriosis into ovarian carcinoma[J].Gynecol Endocrinol,2014,30(9):612-617.doi:10.3109/09513590.2014.926325.
[5]付晨薇,郎景和,沈铿,等.子宫内膜异位症合并卵巢恶性肿瘤的临床特点[J].协和医学杂志,2012,3(2):204-207.doi:10.3969/j.issn.1674-9081.2012.02.016.
[6]慕小燕.bcl-2、PIEN在卵巢子宫内膜异位症癌变过程中的作用观察[J].社区医学杂志,2009,7(15):3-4.
[7]Samartzis E P,Samartzis N,Noske A,et al.Loss of ARID1A/BAF-250a-expression in endometriosis:a biomarker for risk of carcinogenic transformation?[J].Mod Pathol,2012,25(6):885-892.doi:10.1038/modpathol.2011.217.
[8]叶霞,王丽宏,郭志杰.PIEN及p16蛋白表达变化对卵巢子宫内膜异位症癌变的影响[J].中国临床实用医学,2014,5(5):46-47.doi:10.3760/cma.j.issn.1673-8799.2014.05.017.
[9]董春鸽,林雅,章杰,等.基质金属蛋白酶-9及抑癌基因PIEN在子宫内膜异位症中的表达及意义[J].浙江医学,2015,37(23):1913-1915.
[10]蒋苹,许红,王中弥,等.PIEN、Survivin蛋白在子宫内膜异位症相关的卵巢癌组织中表达的相关性及临床意义[J].中国实用医药,2014,15:3-6.
[11]Ma X,Hui Y,Lin L,et al.Possible relevance of tumor-related genes mutation to malignant transformation of endometriosis[J].European Journal Of Gynaecological Oncology,2016,37(1):89-94.
[12]王丽宏,叶霞,吕家峰.卵巢子宫内膜异位症恶性变过程中p53蛋白的表达变化[J].基层医学论坛,2015,33:4614-4616.
[13]姜晓凤,张颐,庞晓燕,等.子宫内膜异位症相关卵巢癌的临床分析[J].中国医科大学学报,2015,1:30-33.doi:10.3969/j.issn.0258-4646.2015.01.007.
[14]庞淑洁,郭冬辉.非典型子宫内膜异位症的免疫标记与恶变潜能[J].医学理论与实践,2014,27(15):1975-1977.
[15]Lin K,Zhan H,Ma J,et al.Increased steroid receptor RNA activator protein(SRAP)accompanied by decreased estrogen receptor-beta(ER-β)levels during the malignant transformation of endometriosis associated ovarian clear cell carcinoma[J].Acta Histochem,2014,116(5):878-882.doi:10.1016/j.acthis.2014.02.007.
[16]Guo C,Ren F,Wang D,et al.RUNX3 is inactivated by promoter hypermethylation in malignant transformation of ovarian endometriosis[J].OncolRep,2014,32(6):2580-2588.doi;10.3892/or.2014.3524.
[17]张颖,王庆一,梁艳红,等.p53、pl6、PIEN、hMLHl蛋白表达与卵巢子宫内膜异位症癌变的关系[J].新医学,2010,41(6):379-382.doi:10.3969/j.issn.0253-9802.2010.06.009.
[18]王成鑫,周红艳,黄萱,等.PIEN.EGFR和GH在子宫内膜异位症和异位恶变内膜中的表达及意义[J].江汉大学学报(自然科学版),2013,41(5):81-85.doi:10.3969/j.issn.1673-0143.2013.05.017.
[19]Dong M,Yang P,Hua F.MiR-191 modulates malignant transformation of endometriosis through regulating TIMP3[J].Med SciMonit,2015,21:915-920.doi:10.12659/MSM.893872.
[20]Tian X,Xu L,Wang P.MiR-191 inhibits TNF-a induced apopto sis of ovarian endometriosis and endometrioid carcinoma cells by targeting DAPK1[J].International Journal Of Clinical And Experimental Pathology,2015,8(5):4933-4942.
[21]Er T K,Su Y F,Wu C C,et al.Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer[J].Journal Of Molecular Medicine(Berlin,Germany),2016,94(7):835-847.doi:10.1007/s00109-016-1395-2.
[22]Anglesio M S,Bashashati A,Wang Y K,et aL Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden[J].The Journal Of Pathology,2015,236(2):201-209.doi:10.1002/path.4516.
[23]沈杨,刘娟,任慕兰.二噁英对小鼠异位子宫内膜影响的分子机制研究[J].中山大学学报(医学科学版),2010,31(5):608-613.
[24]刘娟,任慕兰.二噁英对小鼠异位子宫内膜中IL-1β表达的影响[J].中国妇幼健康研究,2011,22(2):162-164.doi:10.3969/j.issn.1673-5293.2011.02.015.
[25]李佳璘.上皮性卵巢癌合并子宫内膜异位症患者的临床、病理及预后特点[D].大连:大连医科大学,2014.
[26]邹海琼,柴艳婷.卵巢子宫内膜样癌及其合并子宫内膜异位症的临床及病理分析[J].现代中西医结合杂志,2014,5:540-541.doi:10.3969/j.issn.1008-8849.2014.05.037.
[27]张洁,欧阳艳红.卵巢子宫内膜样癌的病因分析及临床特点[J].临床合理用药,2014,7(9):113-114.doi:10.3969/j.issn.1674-3296.2014.27.081.
[28]王琪.围绝经期子宫腺肌病合并子宫内膜癌病例报告并文献复习[D].济南:山东大学,2014.
[29]武艳霞,刘晴,李全荣,等.子宫腺肌病恶变3例临床病理分析[J].现代肿瘤医学,2011,19(9):1834-1838.doi:10.3969/j.issn.1672-4992.2211.09.46.
[30]王力夫,孔令非.子宫腺肌病恶变8例临床病理分析[J].临床与实验病理学杂志,2011,27(3):330-333.doi:10.3969/j.issn.1001-7399.2011.03.033.
[31]李珍玲,金仁顺.卵巢子宫内膜异位症合并卵巢子宫内膜样肿瘤临床病理分析及文献复习[J].现代肿瘤医学,2014,22(9):2177-2179.doi:10.3969/j.issn.1672-4992.2014.09.54.
[32]Tanase Y,Furukawa N,Kobayashi H,et aL Malignant Transformation from Endometriosis to Atypical Endometriosis and Finally to Endometrioid Adenocarcinoma within 10 Years[J].Case Rep Oncol,2013,6(3):480-484.doi:10.1159/000355282.
[33]宋建平.子宫内膜异位症与卵巢癌相关性临床分析[J].现代肿瘤医学,2015,23(10):1432-1434.doi:10.3969/j.issn.1672-4992.2015.10.32.