硼替佐米对难治性弥漫大B细胞淋巴瘤的临床疗效分析
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摘要
目的:采用硼替佐米治疗患者难治性弥漫大B细胞淋巴瘤,通过对其观察,探讨临床疗效及不良反应。方法:对难治性弥漫大B细胞淋巴瘤10例患者采用硼替佐米治疗,评价其临床效果。结果:入组患者行4个周期化疗,完全缓解3例,部分缓解4例,稳定2例,改善率70%,可提高疗效且效果明显,不良反应主要表现乏力2例,低血压1例,白细胞降低、血小板数降低1例,周围神经感觉异常1例。结论:硼替佐米治疗难治性弥漫大B细胞淋巴瘤患者可明显改善症状,在一定程度上提高患者的生活质量,且不良反应轻。
引文
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[3] Cultrera JL,Dalia SM.Diffuse large B-cell lymphoma:currentstrategies and future directions[J].CancerControl,2012, l9(3):204-213.
[4]孙中义,易平勇,刘晰宇,等.ICE方案和GemOX方案治疗复发或难治性弥漫大B细胞淋巴瘤的临床观察[J].中国医师杂志,2013,15(2):242-244.
[5] Zhou Z,Sehn LH,Rademaker AW,et al.An enhanced Internationa1 Prognostic Index rNCCN—IPI、 forpatientsw ith diffuselarge B-cel1lym phoma treated in the rituximabera[J].Blood,2014,123(6):837.842.