急性冠状动脉综合征患者Hcy、UA、Scr、TBIL水平与SYNTAX积分的相关性研究
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摘要
目的探讨急性冠状动脉综合征患者同型半胱氨酸(Hcy)、血尿酸(UA)、血肌酐(Scr)、血清胆红素(TBIL)水平与SYNTAX积分的相关性。方法回顾性分析我院120例急性冠状动脉综合征患者,根据患者SYNTAX积分分为低危组53例、中危组46例、高危组21例。收集患者一般资料以及血生化资料,比较三组患者血生化指标水平,并进行相关性分析。结果高危组男性、年龄大于65岁、吸烟、有冠心病家族史的比例明显高于低危组(P<0.05),三组患者在不良饮食方式、脑卒中史的分布上差异无统计学意义(P>0.05)。高危组Hcy、UA、Scr水平高于低危组,TBIL水平低于低危组(P<0.05)。Hcy、UA水平与SYNTAX积分成正相关(P<0.05),TBIL水平与SYNTAX积分成负相关(P<0.05),Scr水平与SYNTAX积分无明显相关关系(P>0.05)。结论急性冠状动脉综合征患者Hcy、UA、TBIL水平与SYNTAX积分具有相关性,可作为判断冠脉病变严重程度的辅助指标。
Objective To investigate the relationship of levels of homocysteine(Hcy), serum uric acid(UA), serum creatinine(Scr)and serum total bilirubin(TBIL) with SYNTAX integrals in patients with acute coronary syndrome(ACS). Methods A retrospective analysis was performed on 120 patients with ACS in the hospital. According to SYNTAX integrals of patients, they were divided into low-risk group(53 cases), intermediate-risk group(46 cases) and high-risk group(21 cases). The general data and blood biochemical data were collected. The levels of blood biochemical indicators of the three groups were compared. The correlation analysis was conducted. Results The proportion of males, age more than 65 years old, smoking and family history of coronary heart disease in the high-risk group was significantly higher than that in the low-risk group(P<0.05). There was no significant difference in the distribution of adverse eating patterns or stroke history among the three groups(P>0.05). The levels of Hcy, UA and Scr in the high-risk group were higher than those in the low-risk group, while the level of TBIL was lower than that in the low-risk group(P<0.05). Hcy and UA levels were positively correlated with SYNTAX integrals(P<0.05). TBIL level was negatively correlated with SYNTAX scores(P<0.05), and Scr level was not significantly correlated with SYNTAX integrals(P>0.05). Conclusion The levels of Hcy, UA and TBIL in patients with acute coronary syndrome have a correlation with SYNTAX integrals, which can be used as an auxiliary index to judge the severity of coronary lesions.
Objective To investigate the relationship of levels of homocysteine(Hcy), serum uric acid(UA), serum creatinine(Scr)and serum total bilirubin(TBIL) with SYNTAX integrals in patients with acute coronary syndrome(ACS). Methods A retrospective analysis was performed on 120 patients with ACS in the hospital. According to SYNTAX integrals of patients, they were divided into low-risk group(53 cases), intermediate-risk group(46 cases) and high-risk group(21 cases). The general data and blood biochemical data were collected. The levels of blood biochemical indicators of the three groups were compared. The correlation analysis was conducted. Results The proportion of males, age more than 65 years old, smoking and family history of coronary heart disease in the high-risk group was significantly higher than that in the low-risk group(P<0.05). There was no significant difference in the distribution of adverse eating patterns or stroke history among the three groups(P>0.05). The levels of Hcy, UA and Scr in the high-risk group were higher than those in the low-risk group, while the level of TBIL was lower than that in the low-risk group(P<0.05). Hcy and UA levels were positively correlated with SYNTAX integrals(P<0.05). TBIL level was negatively correlated with SYNTAX scores(P<0.05), and Scr level was not significantly correlated with SYNTAX integrals(P>0.05). Conclusion The levels of Hcy, UA and TBIL in patients with acute coronary syndrome have a correlation with SYNTAX integrals, which can be used as an auxiliary index to judge the severity of coronary lesions.
引文
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[17]Kunutsor SK.Serum total bilirubin levels and coronary heart disease--Causa association or epiphenomenon[J].Exp Gerontol,2015,12(72):63-66.
[2]Chang X,Salim A,Dorajoo R,et al.Utility of genetic and non-genetic risk factors in predicting coronary heart disease in Singaporean Chinese[J].Eur JPrev Cardiol,2017,24(2):153-160.
[3]Adger D.Syntax[J].Wiley Interdiscip Rev Cogn Sci,2015,6(2):131-147.
[4]张波,赵晓辉,晋军.SYNTAX积分在合并冠状动脉多支血管病变的STEMI患者急诊PCI策略中的应用[J].重庆医学,2016,45(21):2949-2952
[5]中华医学会心血管病学分会.非ST段抬高急性冠状动脉综合征诊断和治疗指南[J].中华心血管病杂志,2012,40(5):353-367.
[6]Choudhary S.Association of syntax score with short-term outcomes among acute ST-elevation myocardial infarction patients undergoing primary PCI[J]Indian Heart J,2017,69(1):20-23.
[7]Milojevic M,Head SJ,Parasca CA,et al.Causes of death following pc versus cabg in complex cad:5-year follow-up of SYNTAX[J].J Am Col Cardiol,2016,67(1):42-55.
[8]Karadimas H,Ebrahiminia V,Lepage E.User-defined functions in the Arden Syntax:An extension proposal[J].Artif Intell Med,2018,11(92):103-110.
[9]孙宇姣,齐国先,俞鑫,等.性别对疑似冠心病患者的冠状动脉病变的影响[J].中华医学杂志,2015,95(41):3337-3342.
[10]董华,翟凤燕.冠心病吸烟患者临床及冠状动脉特点研究[J].实用心脑肺血管病杂志,2014,22(2):54-55.
[11]王鹏,刘玉洁,周秀军,等.冠状动脉左主干病变SYNTAX积分与血清同型半胱氨酸等血液参数水平的关系[J].中国慢性病预防与控制,2016,12(8):611-614.
[12]Han TW,Zhou SS,Li JT,et al.Homocysteine is associated with the progression of non-culprit coronary lesions in elderly acute coronary syndrome patients after percutaneous coronary intervention[J].J Geriatr Cardiol,2016,13(4):299-305.
[13]严宁.冠心病患者血浆Hcy水平与冠状动脉病变SYNTAX积分之间的相关性研究[D].宁夏医科大学,2015.
[14]蒋汉涛,丛洪良.SYNTAX积分判断血尿酸水平与冠心病严重程度的价值[J].天津医药,2012,40(9):940-941.
[15]解存,王明辉,胡越成,等.阻塞性睡眠呼吸暂停低通气综合征与冠心病血管病变及血清学的关系[J].天津医药,2017,45(6):601-604.
[16]胡林.冠心病患者血清胆红素水平与SYNTAX积分及临床SYNTAX积分相关性及预测经皮冠状动脉介入治疗的预后作用研究[D].南昌大学,2016.
[17]Kunutsor SK.Serum total bilirubin levels and coronary heart disease--Causa association or epiphenomenon[J].Exp Gerontol,2015,12(72):63-66.