宣痹通络膏治疗痛风(湿热痹阻证)60例临床观察
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摘要
目的:观察宣痹通络膏治疗痛风(湿热痹阻证)的疗效。方法:纳入痛风(湿热痹阻证)患者60例,按就诊顺序随机分成治疗组和对照组各30例。治疗组予基础治疗及宣痹通络膏治疗;对照组予基础治疗及痛风定胶囊治疗。分别记录患者治疗前后关节疼痛、压痛、急性红肿及活动受限积分。采用常规清晨空腹抽血检测血尿酸(UA);采用魏氏法检测血沉(ESR);采用速率散射免疫比浊法检测血清C-反应蛋白(CRP),并记录治疗过程中的不良反应。结果:治疗组总有效率为90.0%,对照组总有效率为83.3%,两组比较,差异无统计学意义(P>0.05);两组治疗前后关节症状改善及ESR、CRP水平比较,差异无统计学意义(P>0.05);两组治疗后UA比较,治疗组低于对照组(P<0.05)。结论:宣痹通络膏治疗痛风(湿热痹阻证)疗效良好,可明显改善关节疼痛、压痛、急性红肿及活动受限,降低UA、ESR、CRP。
Objective:To observe the clinical efficacy of Xuanbi Tongluo cream on gout(heat blockage syndrome).Methods:The 60 cases of patients with gout(heat blockage syndrome) were selected and randomly divided into treatment and control groups,30 cases in each.Patients were treated by basic treatment and Xuanbi Tongluo cream in treatment group,and Tongfengding capsule as well as basic treatment in control group.The joint pain,tenderness,swelling,and limitation of activity acute points were recorded before and after the treatment.The serum uric acid(UA) was tested with conventional fasting blood test;Westergren assay was applied to test ESR(ESR);the serum C-reactive protein(CRP) was tested by rate nephelometric immunoassay assay.And adverse reactions were record during treatment.Results:The total efficiency was 90.0% in treatment group and 83.3% in control group,and the comparison showed no statistical difference(P>0.05);The comparison on improvement of joint symptoms,ESR and CRP levels between the two groups showed no statistical difference(P>0.05).The treatment group showed lower level of UA than the control group(P <0.05).Conclusion:Xuanbi Tongluo cream can provide good efficacy on gout(heat blockage syndrome),relieve joint pain,tenderness,acute swelling and limited mobility,and reduce indicators of UA,ESR and CRP.
Objective:To observe the clinical efficacy of Xuanbi Tongluo cream on gout(heat blockage syndrome).Methods:The 60 cases of patients with gout(heat blockage syndrome) were selected and randomly divided into treatment and control groups,30 cases in each.Patients were treated by basic treatment and Xuanbi Tongluo cream in treatment group,and Tongfengding capsule as well as basic treatment in control group.The joint pain,tenderness,swelling,and limitation of activity acute points were recorded before and after the treatment.The serum uric acid(UA) was tested with conventional fasting blood test;Westergren assay was applied to test ESR(ESR);the serum C-reactive protein(CRP) was tested by rate nephelometric immunoassay assay.And adverse reactions were record during treatment.Results:The total efficiency was 90.0% in treatment group and 83.3% in control group,and the comparison showed no statistical difference(P>0.05);The comparison on improvement of joint symptoms,ESR and CRP levels between the two groups showed no statistical difference(P>0.05).The treatment group showed lower level of UA than the control group(P <0.05).Conclusion:Xuanbi Tongluo cream can provide good efficacy on gout(heat blockage syndrome),relieve joint pain,tenderness,acute swelling and limited mobility,and reduce indicators of UA,ESR and CRP.
引文
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[13]孟红亮,奚肇庆,韩丽.膏方近6年的临床研究进展与展望[J].世界中西医结合杂志,2013,8(5):534-536.
[14]唐博祥,姚叙滢,朱侑仪,等.中药膏方临床应用概况[J].中医药导报,2011,17(4):125-127.
[2]旷惠桃.中医药治疗痛风研究概述[J].湖南中医杂志,2005,21(2):79-80.
[3]Wallace SL,Robinson H,Masi AT,et al.Preliminary criteria for the classifycation of the acute arthritis of primary gout[J].Arthritis Rheum,1977,20(3):895-900.
[4]孟凤仙,郝桂香,张继胜,等.青秦液对高尿酸血症模型大鼠关节免疫性病理损伤的修复作用[J].中国中医药信息杂志,2009,16(6):26-28.
[5]王贺波.11点疼痛数字等级量表测定慢性疼痛程度的临床意义[J].中国疼痛医学杂志,2002,8(1):42.
[6]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.
[7]陈炼.自拟痛风关立消汤治疗急性痛风性关节炎41例临床观察[J].中医药导报,2011,17(6):47-49.
[8]牛宝华,孙旸圆,王会侠,等.中西医结合治疗急性痛风性关节炎的临床观察[J].中医药导报,2014,20(12):81-83.
[9]雷静,刘志豪,贾琼.四妙丸加味联合英夫利昔单抗治疗强直性脊柱炎30例临床观察[J].中医药导报,2015,21(15):74-76.
[10]王建平,张海燕,傅旭春.土茯苓的化学成分和药理作用研究进展[J].海峡药学,2013,25(1):42-44.
[11]国家中医药管理局《中华本草》编委会.中华本草精选本[M].上海:上海科学技术出版社,1996:1042,1888,404,2140.
[12]蒋林祥.四妙散加减治疗痛风的疗效观察及中药药理分析[J].医学美学美容,2012,22(12):23-24.
[13]孟红亮,奚肇庆,韩丽.膏方近6年的临床研究进展与展望[J].世界中西医结合杂志,2013,8(5):534-536.
[14]唐博祥,姚叙滢,朱侑仪,等.中药膏方临床应用概况[J].中医药导报,2011,17(4):125-127.