抗环瓜氨酸肽抗体检测在类风湿关节炎中的应用
|
摘要
目的探讨在类风湿关节炎患者中应用抗环瓜氨酸肽抗体检测的效果,为临床提供指导。方法选择2017年3月～2018年9月来我院治疗的68例类风湿关节炎患者作为观察组,并选择同期接受治疗的50例非类风湿关节炎患者作为对照1组及同期来我院行体检的50例正常人志愿者作为对照2组,对所有观察对象均实施类风湿因子及抗环瓜氨酸肽抗体检测,对比分析所有观察对象类风湿因子及抗环瓜氨酸肽抗体的检测结果。结果 (1)观察组患者治疗后抗环瓜氨酸肽抗体浓度低于患者治疗前,P <0.05;(2)骨侵蚀组患者治疗后的抗环瓜氨酸肽抗体浓度均明显高于非骨侵蚀组患者,且骨侵蚀组Ⅳ期患者治疗后的抗环瓜氨酸肽抗体浓度明显高于Ⅲ期、Ⅱ期、Ⅰ期患者,P <0.05。结论在类风湿关节炎患者中应用抗环瓜氨酸肽抗体检测具有较佳的效果,对诊断患者病情、监测治疗及评估患者治疗效果具有十分积极的作用。
Objective To explore the effect of anti-cyclic citrullinated peptide(anti CCP) antibody detection in patients with rheumatoid arthritis,and to provide guidance for clinical practice. Methods Sixty-eight patients with rheumatoid arthritis treated in our hospital from March 2017 to September 2018 were selected as observation group,and 50 non-rheumatoid arthritis patients treated in the same period were selected as control group 1 and 50 normal volunteers who had physical examination in our hospital during the same period were selected as control group 2.Rheumatoid factor and anti-cyclic citrullinated peptide antibody were detected in all subjects,and the detection results of rheumatoid factor and anti-cyclic citrullinated peptide antibody in all subjects were compared and analyzed. Results(1)The concentration of anti-cyclic citrullinated peptide antibody in the observation group after treatment was lower than that before treatment(P < 0.05);(2)The concentration of anti-cyclic citrullinated peptide antibody in the bone erosion group was significantly higher than that in the nonbone erosion group.After treatment,the concentration of anti-cyclic citrullinated peptide antibody of patients with bone erosion group in the stage IV was significantly higher than that in the stage Ⅲ, Ⅱ and Ⅰ(P < 0.05).Conclusion The application of anti-cyclic citrullinated peptide antibody detection in treatment of rheumatoid arthritis patients has a better effect,patients of diagnosis,monitoring treatment and evaluating curative effect in patients with a very positive role.
Objective To explore the effect of anti-cyclic citrullinated peptide(anti CCP) antibody detection in patients with rheumatoid arthritis,and to provide guidance for clinical practice. Methods Sixty-eight patients with rheumatoid arthritis treated in our hospital from March 2017 to September 2018 were selected as observation group,and 50 non-rheumatoid arthritis patients treated in the same period were selected as control group 1 and 50 normal volunteers who had physical examination in our hospital during the same period were selected as control group 2.Rheumatoid factor and anti-cyclic citrullinated peptide antibody were detected in all subjects,and the detection results of rheumatoid factor and anti-cyclic citrullinated peptide antibody in all subjects were compared and analyzed. Results(1)The concentration of anti-cyclic citrullinated peptide antibody in the observation group after treatment was lower than that before treatment(P < 0.05);(2)The concentration of anti-cyclic citrullinated peptide antibody in the bone erosion group was significantly higher than that in the nonbone erosion group.After treatment,the concentration of anti-cyclic citrullinated peptide antibody of patients with bone erosion group in the stage IV was significantly higher than that in the stage Ⅲ, Ⅱ and Ⅰ(P < 0.05).Conclusion The application of anti-cyclic citrullinated peptide antibody detection in treatment of rheumatoid arthritis patients has a better effect,patients of diagnosis,monitoring treatment and evaluating curative effect in patients with a very positive role.
引文
[1]张彩虹,白建红.抗环瓜氨酸肽抗体检测对类风湿关节炎的诊断价值[J].包头医学,2016,40(4):209-210.
[2]Egholm Cecilie Lindstrom,Krogh Niels Steen,Pincus Theodore,et al.Discordance of Global Assessments by Patient and Physician Is Higher in Female than in Male Patients Regardless of the Physician's Sex:Data on Patients with Rheumatoid Arthritis,Axial Spondyloarthritis,and Psoriatic Arthritis from the DANBIO Registry[J].The Journal of Rheumatology,2015,42(10):1781-1785.
[3]封昱辰,房晴晴,蔺军平,等.葡萄糖-6-磷酸异构酶、抗环瓜氨酸肽抗体、类风湿因子联合检测对类风湿关节炎的诊断价值[J].检验医学,2016,31(7):567-570.
[4]戴冰冰,雷蕾,刘畅,等.血清14-3-3η蛋白联合抗环瓜氨酸肽抗体对类风湿关节炎的诊断价值[J].临床内科杂志,2018,35(4):251-254.
[5]李传利,王延群,郭淼,等.嗜酸性粒细胞趋化因子-1、类风湿因子和抗环瓜氨酸肽抗体与类风湿关节炎活动度的相关性分析[J].临床检验杂志,2017,35(1):28-30.
[6]王洋一.抗环瓜氨酸肽抗体对早期类风湿关节炎的辅助诊断价值[J].中国实验诊断学,2017,21(3):426-428.
[7]张露月,史丽璞,茹晋丽,等.抗突变型瓜氨酸波形蛋白抗体抗环瓜氨酸肽抗体对类风湿关节炎与幼年特发性关节炎患者诊断价值的比较[J].中华风湿病学杂志,2018,22(3):176-180.
[8]王光彦,高冬花,龚丽坤,等.抗环瓜氨酸肽抗体和类风湿因子分型联合检测在类风湿关节炎诊断中的应用[J].国际检验医学杂志,2016,37(5):696-697.
[9]张杨文.类风湿性关节炎血清RF与抗-CCP抗体浓度检测及其意义[J].实用医学杂志,2015,31(1):108-109.
[10]高雅,王晓非.胸腺基质淋巴细胞生成素在类风湿关节炎和有关节症状的系统性红斑狼疮患者外周血中的表达及其意义[J].吉林大学学报(医学版),2016,42(3):556-560.
[11]丁红梅,刘建华,贾曙光,等.钙网织蛋白在早期类风湿关节炎中的表达及其与自身抗体和炎性细胞因子的关系[J].天津医药,2018,46(1):84-87.
[12]刘婕,华星.抗CCP抗体与RF检测在丙型肝炎病毒相关性关节病中的诊断价值[J].检验医学与临床,2018,15(7):1029-1030.
[13]范俊,郭洪佩,徐瑛,等.抗环瓜氨酸肽抗体、抗角蛋白抗体及类风湿因子联合检测在类风湿关节炎诊断中的应用[J].临床和实验医学杂志,2016,15(7):656-658,659.
[14]Santos-Moreno Pedro,Galarza-Maldonado Claudio,Caballero-Uribe Carlo V.et al.REAL-PANLAR Project for the Implementation and Accreditation of Centers of Excellence in Rheumatoid Arthritis Throughout Latin America A Consensus Position Paper From REALPANLARGrouponImprovementofRheumatoid Arthritis Care in Latin America Establishing Centers of Excellence[J].Journal of Clinical Rheumatology,2015,21(4):175-180.
[15]李勇军,陈婧,陈仁德,等.类风湿因子和抗环瓜氨酸肽抗体阴性对类风湿关节炎患者临床分析及血清红细胞沉降率、C反应蛋白水平表达[J].中国临床医生杂志,2018,46(6):692-695.
[2]Egholm Cecilie Lindstrom,Krogh Niels Steen,Pincus Theodore,et al.Discordance of Global Assessments by Patient and Physician Is Higher in Female than in Male Patients Regardless of the Physician's Sex:Data on Patients with Rheumatoid Arthritis,Axial Spondyloarthritis,and Psoriatic Arthritis from the DANBIO Registry[J].The Journal of Rheumatology,2015,42(10):1781-1785.
[3]封昱辰,房晴晴,蔺军平,等.葡萄糖-6-磷酸异构酶、抗环瓜氨酸肽抗体、类风湿因子联合检测对类风湿关节炎的诊断价值[J].检验医学,2016,31(7):567-570.
[4]戴冰冰,雷蕾,刘畅,等.血清14-3-3η蛋白联合抗环瓜氨酸肽抗体对类风湿关节炎的诊断价值[J].临床内科杂志,2018,35(4):251-254.
[5]李传利,王延群,郭淼,等.嗜酸性粒细胞趋化因子-1、类风湿因子和抗环瓜氨酸肽抗体与类风湿关节炎活动度的相关性分析[J].临床检验杂志,2017,35(1):28-30.
[6]王洋一.抗环瓜氨酸肽抗体对早期类风湿关节炎的辅助诊断价值[J].中国实验诊断学,2017,21(3):426-428.
[7]张露月,史丽璞,茹晋丽,等.抗突变型瓜氨酸波形蛋白抗体抗环瓜氨酸肽抗体对类风湿关节炎与幼年特发性关节炎患者诊断价值的比较[J].中华风湿病学杂志,2018,22(3):176-180.
[8]王光彦,高冬花,龚丽坤,等.抗环瓜氨酸肽抗体和类风湿因子分型联合检测在类风湿关节炎诊断中的应用[J].国际检验医学杂志,2016,37(5):696-697.
[9]张杨文.类风湿性关节炎血清RF与抗-CCP抗体浓度检测及其意义[J].实用医学杂志,2015,31(1):108-109.
[10]高雅,王晓非.胸腺基质淋巴细胞生成素在类风湿关节炎和有关节症状的系统性红斑狼疮患者外周血中的表达及其意义[J].吉林大学学报(医学版),2016,42(3):556-560.
[11]丁红梅,刘建华,贾曙光,等.钙网织蛋白在早期类风湿关节炎中的表达及其与自身抗体和炎性细胞因子的关系[J].天津医药,2018,46(1):84-87.
[12]刘婕,华星.抗CCP抗体与RF检测在丙型肝炎病毒相关性关节病中的诊断价值[J].检验医学与临床,2018,15(7):1029-1030.
[13]范俊,郭洪佩,徐瑛,等.抗环瓜氨酸肽抗体、抗角蛋白抗体及类风湿因子联合检测在类风湿关节炎诊断中的应用[J].临床和实验医学杂志,2016,15(7):656-658,659.
[14]Santos-Moreno Pedro,Galarza-Maldonado Claudio,Caballero-Uribe Carlo V.et al.REAL-PANLAR Project for the Implementation and Accreditation of Centers of Excellence in Rheumatoid Arthritis Throughout Latin America A Consensus Position Paper From REALPANLARGrouponImprovementofRheumatoid Arthritis Care in Latin America Establishing Centers of Excellence[J].Journal of Clinical Rheumatology,2015,21(4):175-180.
[15]李勇军,陈婧,陈仁德,等.类风湿因子和抗环瓜氨酸肽抗体阴性对类风湿关节炎患者临床分析及血清红细胞沉降率、C反应蛋白水平表达[J].中国临床医生杂志,2018,46(6):692-695.