摘要
目的:综述近几年来中医药治疗慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)稳定期的研究进展。方法:通过检索近年来治疗COPD稳定期的中医临床相关研究文献,对COPD稳定期的病因病机、治疗方法等做出总结。结果:COPD稳定期病因病机多为本虚标实,病位在肺反复感受外邪,久病肺虚,继而影响脾、肾二脏,出现气滞、血瘀、痰凝。治疗上以调补肺脾肾三脏,兼以祛痰化瘀、结合中医外治。结论:中医药治疗COPD稳定期具有独特的疗效。
Objective: To summarize the research progress of traditional Chinese medicine(TCM) in the treatment of stabilized patients with chronic obstructive pulmonary disease(COPD) in recent years. Methods: By retrieving the literature of TCM clinical research on stabilized patients with COPD in recent years, the etiology, pathogenesis and treatment methods of COPD stabilization were summarized. Results: The etiology and pathogenesis of COPD in the stable stage are mostly based on deficiency and marked reality. The location of COPD is repeatedly suffered from exogenous pathogens. COPD leads to lung deficiency, which then affects the spleen and kidney, resulting in Qi stagnation, blood stasis and phlegm coagulation. In order to improve the lungs, spleen and kidneys, removing phlegm and blood stasis combined with external treatment of TCM was applied in the treatment of stabilized patients with COPD. Conclusion: TCM has a unique curative effect in stabilized patients with COPD.
引文
[1]中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中华结核和呼吸杂志,2013,36(4):255-264.
[2]杨秀云,杨中良.COPD稳定期维持治疗的研究进展[J].浙江医学,2013(13):1307-1309.
[3]李竹英,田春燕,刘文波.慢性阻塞性肺疾病稳定期中医病因病机概述[J].中国中医急症,2014,23(1):92-94.
[4]张才圣,柏正平,胡学军,等.慢性阻塞性肺疾病稳定期中医证型分布规律研究[J].湖南中医杂志,2017,33(4):132-133.
[5]乐永红,杨慧琴,李风森.慢性阻塞性肺疾病稳定期中医证型分布规律研究[J].实用中医内科杂志,2011,25(4):100-102.
[6]玛依努尔·斯买拉洪,万智,阿力木卡特尔,等.补肺健脾益肾方治疗对老年COPD稳定期患者T淋巴细胞亚群、BODE指数及生活质量的影响[J].海南医学院学报,2015,21(7):920-922,925.
[7]蒋荣民,黄少祥,曲由,等.参苓白术散辅助舒氟美治疗稳定期慢性阻塞性肺疾病疗效观察[J].山东医药,2013,53(35):37-38.
[8]叶淑清.自拟补肺健脾汤联合益气固表丸对慢性阻塞性肺疾病稳定期患者肺功能及生活质量的影响[J].山西医药杂志,2018,47(18):2222-2223.
[9]祝建材,宋丽华,王海亭.补肾益金汤治疗慢性阻塞性肺病稳定期的临床研究[J].湖北中医杂志,2011,33(10):8-9.
[10]傅元冬,朱桂松.健脾补肾法治疗轻中度慢性阻塞性肺疾病稳定期患者47例[J].环球中医药,2016,9(9):1114-1116.
[11]Bruno,A.Does leptin play a cytokine-like role within the airways of COPD patients[J].European Respiratory Journal,2005,26(3):398-405.
[12]Krommidas G,Kostikas K,Papatheodorou G,et al.Plasma leptin and adiponectin in COPD exacerbations:Associations with inflammatory biomarkers[J].Respiratory Medicine,2009,104(1):40-46.
[13]Naveed B,Weiden M D,Kwon S,et al.Metabolic syndrome biomarkers predict lung function impairment A nested case-control study[J].American Journal of Respiratory and Critical Care Medicine,2011,185(4):392-399.
[14]Otero M,Lago R,Lago F,et al.Leptin,from fat to inflammation:old questions and new insights[J].Febs Letters2005,579(2):295-301.
[15]冯月娟,王灿灿,童岳阳,等.补肾健脾益气方对慢性阻塞性肺疾病大鼠瘦素及瘦素受体表达的影响[J].浙江中医杂志,2018,53(2):99-100.
[16]高青.补肺益肾法对慢性阻塞性肺疾病肺功能、急性发作次数、m MRC分级的影响[J].河南中医,2018,38(11):1706-1709.
[17]田燕歌,董浩然,刘学芳,等.补肺益肾方对慢性阻塞性肺疾病模型大鼠肺泡表面活性蛋白A、D及肺泡结构的影响[J].中医学报,2018,33(1):99-105.
[18]王浩舟,陈斯宁.慢性阻塞性肺疾病稳定期中药治疗的研究进展[J].内蒙古中医药,2016,35(3):123-124.
[19]章淑芳,陈建建,涂长英.补肺益肾、祛痰行瘀法治疗慢性阻塞性肺疾病稳定期肺功能指标的研究[J].江西医药,2011,46(10):916-917.
[20]费建荣,朱佳威.活血祛瘀化痰法对慢性阻塞性肺疾病伴肺心病患者高凝血状态及心肺功能的影响[J].中国生化药物杂志,2017,37(6):129-130.
[21]邹春燕.加味补肺汤治疗COPD稳定期肺肾气阴两虚证患者的临床研究[D].福州:福建中医药大学,2014:1-37.
[22]释涤凡.益气养阴化痰活血法治疗气阴两虚痰瘀伏肺型慢性阻塞性肺疾病稳定期患者的临床疗效评价[J].山西医药杂志,2017,46(23):2888-2890.
[23]朱吉鹏.温针灸对老年稳定期慢性阻塞性肺疾病患者肺功能的影响[J].深圳中西医结合杂志,2017,1:49-51.
[24]陈伟云,梁炳辉,詹伟杰.金匮肾气丸联合穴位敷贴治疗肾阳虚证型慢性阻塞性肺疾病稳定期的疗效及对免疫功能的影响[J].国际呼吸杂志,2018,38(16):1231-1235.
[25]孟晶晶,沈云霞.穴位埋线治疗慢性阻塞性肺疾病稳定期45例[J].云南中医中药杂志,2017,38(2):106-107.