辐照空心纤维透析器剂量分布的蒙特卡罗模拟
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摘要
运用蒙特卡罗(MCNP)程序模拟计算空心纤维透析器产品在工业钴-60辐照灭菌过程中的剂量分布。实验验证结果表明,理论计算结果和实际测量值之间的相对偏差在±15%以内,两者的剂量分布规律具有一定的相似性。利用MCNP模拟计算方法,可以预测空心纤维透析器产品剂量分布规律,对于产品装载模式的设计、最大和最小剂量区域的确定具有指导意义。
The Monte Carlo method(MCNP) was used to simulate the absorbed dose distribution in an artificial kidney dialyzer product irradiated with60 Co gamma-rays for sterilization. The results showed that the relative deviation between the MCNP simulation value and the measured data was within ±15% and that the dose distribution laws of the two methods were similar. Predetermining the dose mapping of an artificial kidney dialyzer product during irradiation through MCNP simulation is useful. The MCNP simulation method provides valuable information for designing loading patterns and determining the minimum and maximum dose zones of the product.
The Monte Carlo method(MCNP) was used to simulate the absorbed dose distribution in an artificial kidney dialyzer product irradiated with60 Co gamma-rays for sterilization. The results showed that the relative deviation between the MCNP simulation value and the measured data was within ±15% and that the dose distribution laws of the two methods were similar. Predetermining the dose mapping of an artificial kidney dialyzer product during irradiation through MCNP simulation is useful. The MCNP simulation method provides valuable information for designing loading patterns and determining the minimum and maximum dose zones of the product.
引文
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2国家食品药品监督管理总局.GB18280.1-2015:医疗保健产品灭菌-辐射-第1部分:医疗器械灭菌过程的开发、确认和常规控制要求[S].北京:中国标准出版社2015.China Food and Drug Administration.GB18280.1-2015Sterilization of health care products-radiation-part 1requirements for development,validation and routine control of a sterilization process for medical devices[S]Beijing:Standards Press of China,2015.
3张荣履,邓华川.辐射加工的剂量学保证[J].实用测试技术,1994,20(1):41-42/45.ZHANG Ronglyu,DENG Huachuan.Radiation dosemetry guarantee in irradiation process[J].Practical Measurement Technology,1994,20(1):41-42/45.
4 American Society for Testing and Materials.Standard guide for selection and use of mathematical methods for calculating absorbed dose in radiation processing applications:ASTME 2232-2002[S].Conshohocken:ASTM,2002.
5王建华,邱小平,罗志平,等.60Co辐照装置剂量场均匀性的优化设计[J].辐射研究与辐射工艺学报,2008,26(1):5-8.DOI:10.3969/j.issn.1000-3436.2008.01.002.WANG Jianhua,QIU Xiaoping,LUO Zhiping,et al.Optimal design of uniformity of dose field in irradiation facility[J].Journal of Radiation Research and Radiation Processing,2008,26(1):5-8.DOI:10.3969/j.issn.1000-3436.2008.01.002.
6 Radiation Safety Information Computational Center.RSICC computer code collection MCNP4C[R].Los Alamos,New Mexico:Los Alamos National Laboratory,2000.
7 International Organization for Standardization.Sterilization of health care products-radiation-part3:guidance on dosimetric aspects:ISO 11137-3:2006[S].Geneva:ISO,2006.
8国家食品药品监督管理总局.心血管植入物和人工器官血液透析器、血液透析滤过器:YY 0053-2008[S].北京:中国标准出版社,2008.China Food and Drug Administration.Cardiovascular im‐plants and artificial organs hemodialysis devices,hemodi‐alysis filters:YY 0053-2008[S].Beijing:Standards Press of China,2008.
9 American Society for Testing and Materials.Standard guide for absorbed-dose mapping in radiation processing facilities:ASTM E 2303-2011[S].Conshohocken:ASTM,2011.
10 The Panel on Gamma and Electron Irradiation Modelling Working Group.Review of Monte Carlo modelling codes.The Panel on Gamma and Electron Irradiation Modelling Working Group guide for process control in radiation sterilization(2010)[R].(2017-05-17)[2018-09-17].https://www.irradiationpanel.org/app/download/3781272/Guide+Monte+Carlo+modelling+2010.pdf