消旋卡多曲联合蒙脱石散治疗小儿轮状病毒肠炎对患儿心肌酶谱水平、大便情况及临床疗效影响分析
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摘要
目的探讨消旋卡多曲联合蒙脱石散治疗小儿轮状病毒肠炎对患儿心肌酶谱水平、大便情况及临床疗效的影响。方法 134例轮状病毒肠炎患儿,按入院先后顺序将其分为联合组(69例)与对照组(65例)。两组患儿均给予常规对症治疗,对照组患儿在此基础上给予单纯蒙脱石散治疗,联合组患儿在此基础上给予消旋卡多曲联合蒙脱石散治疗。比较两组患儿治疗前后心肌酶谱水平变化、临床症状缓解时间和临床疗效。结果治疗前,两组患儿肌酸激酶(CK)、乳酸脱氢酶(LDH)、谷草转氨酶(AST)及肌酸激酶同工酶(CK-MB)水平比较差异无统计学意义(P>0.05)。治疗后,两组患儿CK、LDH、AST、CK-MB水平水平较治疗前明显降低,差异具有统计学意义(P<0.05);治疗后,两组患儿LDH、AST水平比较差异无统计学意义(P>0.05),联合组CK、CK-MB水平明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,联合组患儿退热时间、止吐时间、止泻时间、大便恢复正常时间、脱水纠正时间均明显短于对照组,差异具有统计学意义(P<0.05)。联合组患儿总有效率为97.10%,对照组患儿总有效率为70.77%,联合组总有效率明显高于对照组,差异具有统计学意义(P<0.05)。结论与单纯使用蒙脱石散治疗小儿轮状病毒肠炎相比,消旋卡多曲联合蒙脱石散治疗小儿轮状病毒肠炎,可有效保护患儿胃肠道黏膜,改善其临床症状,促使临床疗效显著提高,值得推广。
Objective To discuss the effect of racecadotril combined with montmorillonite powder on myocardial zymogram, stool status and clinical efficacy in children with rotavirus enteritis. Methods A total of 134 children with rotavirus enteritis were divided by admission order into combination group(69 cases) and control group(65 cases). Both groups received regular symptomatic treatment, and the control group was also treated with montmorillonite powder. The combination group was treated with racecadotril and montmorillonite powder. The myocardial enzyme level changes before and after treatment, clinical symptom remission time and clinical efficacy in the two groups was compared. Results Before treatment, there was no statistically significant difference in the levels of creatine kinase(CK), lactate dehydrogenase(LDH), aspartate aminotransferase(AST) and creatine kinase isoenzyme(CK-MB) between the two groups(P>0.05). After treatment, both groups had obviously lowerCK, LDH, AST and CK-MB level than those before treatment, and the difference was statistically significant(P<0.05). Both groups had no statistically significant difference in LDH and AST level after treatment(P>0.05). The combination group had obviously lower CK and CK-MB level than the control group, and the difference was statistically significant(P<0.05). After treatment, the combination group had obviously shorter antipyretic time, antiemetic time, diarrhea time, stool return to normal time, dehydration correction time than the control group, and their difference was statistically significant(P<0.05). The combination group had total effective rate as 97.10%, which was 70.77% in the control group. The combination group had obviously higher total effective rate than the control group, and the difference was statistically significant(P<0.05). Conclusion Compared with the simple use of montmorillonite powder in the treatment of infantile rotavirus enteritis, combination of racecadotril and montmorillonite powder can effectively protect the gastrointestinal mucosa of children with rotavirus enteritis, improve their clinical symptoms, and promote the clinical efficacy to improve significantly.It is worthy of promotion.
Objective To discuss the effect of racecadotril combined with montmorillonite powder on myocardial zymogram, stool status and clinical efficacy in children with rotavirus enteritis. Methods A total of 134 children with rotavirus enteritis were divided by admission order into combination group(69 cases) and control group(65 cases). Both groups received regular symptomatic treatment, and the control group was also treated with montmorillonite powder. The combination group was treated with racecadotril and montmorillonite powder. The myocardial enzyme level changes before and after treatment, clinical symptom remission time and clinical efficacy in the two groups was compared. Results Before treatment, there was no statistically significant difference in the levels of creatine kinase(CK), lactate dehydrogenase(LDH), aspartate aminotransferase(AST) and creatine kinase isoenzyme(CK-MB) between the two groups(P>0.05). After treatment, both groups had obviously lowerCK, LDH, AST and CK-MB level than those before treatment, and the difference was statistically significant(P<0.05). Both groups had no statistically significant difference in LDH and AST level after treatment(P>0.05). The combination group had obviously lower CK and CK-MB level than the control group, and the difference was statistically significant(P<0.05). After treatment, the combination group had obviously shorter antipyretic time, antiemetic time, diarrhea time, stool return to normal time, dehydration correction time than the control group, and their difference was statistically significant(P<0.05). The combination group had total effective rate as 97.10%, which was 70.77% in the control group. The combination group had obviously higher total effective rate than the control group, and the difference was statistically significant(P<0.05). Conclusion Compared with the simple use of montmorillonite powder in the treatment of infantile rotavirus enteritis, combination of racecadotril and montmorillonite powder can effectively protect the gastrointestinal mucosa of children with rotavirus enteritis, improve their clinical symptoms, and promote the clinical efficacy to improve significantly.It is worthy of promotion.
引文
[1]黄飞燕,曾令渊,黄托,等.喜炎平联合双歧杆菌和蒙脱石散治疗小儿轮状病毒肠炎.山西医药杂志, 2016, 45(20):2408-2410.
[2]中华医学会儿科学分会感染学组.儿童腹泻病诊断治疗原则的专家共识.病毒感染与儿科消化系统疾病专题研讨会, 2012,48(4):260-262.
[3]田希澜.小儿腹泻病的诊断与治疗.中国中医药咨讯, 2010,2(34):308.
[4]解红艺,华旭丹.蒙脱石散联合消旋卡多曲治疗小儿轮状病毒性肠炎的疗效观察.中国医刊, 2013, 48(9):73-75.
[5]田应超,吴萍.消旋卡多曲治疗小儿轮状病毒肠炎临床效果分析.临床医药文献电子杂志, 2015, 2(28):5845.
[6]王彩虹.消旋卡多曲治疗小儿轮状病毒肠炎临床观察.内蒙古中医药, 2013, 32(21):50-51.
[7]李妮芝.消旋卡多曲联合蒙脱石散治疗小儿轮状病毒肠炎的临床分析.陕西医学杂志, 2014, 13(12):1665-1666.
[2]中华医学会儿科学分会感染学组.儿童腹泻病诊断治疗原则的专家共识.病毒感染与儿科消化系统疾病专题研讨会, 2012,48(4):260-262.
[3]田希澜.小儿腹泻病的诊断与治疗.中国中医药咨讯, 2010,2(34):308.
[4]解红艺,华旭丹.蒙脱石散联合消旋卡多曲治疗小儿轮状病毒性肠炎的疗效观察.中国医刊, 2013, 48(9):73-75.
[5]田应超,吴萍.消旋卡多曲治疗小儿轮状病毒肠炎临床效果分析.临床医药文献电子杂志, 2015, 2(28):5845.
[6]王彩虹.消旋卡多曲治疗小儿轮状病毒肠炎临床观察.内蒙古中医药, 2013, 32(21):50-51.
[7]李妮芝.消旋卡多曲联合蒙脱石散治疗小儿轮状病毒肠炎的临床分析.陕西医学杂志, 2014, 13(12):1665-1666.