药物新剂型与新技术在中药制剂中的应用开发
摘要
本文介绍了纳米粒、聚合物胶束、前体脂质体、自微乳、原位凝胶、前体药物等药物新剂型和新技术在中药领域中的应用,以期对中药制剂的研究提供参考。
引文
[1]何黎黎,何慕菡,邓黎,等.红景天苷壳聚糖纳米粒包封率的测定[J].华西药学杂志,2014,29(1):27-29.
[2]张勇,高敏姣,张来芳,等.环孢素A白蛋白纳米粒的制备,体外释放及大鼠药代动力学评价[J].中国药科大学学报,2013,44(3):239-243.
[3]李楠,刘志东,范丽丽,等.黄岑素PLGA纳米粒的体外评价及细胞相容性研究[J].天津中医药大学学报,2014,33(1):28-31.
[4]耿丽娟,唐丽华,游本刚,等.α-常春藤皂苷丙烯酸树脂纳米粒的制备及其体外评价[J].中国药房,2013,22(3):367-372.
[5]周丽君,刘建平,熊非,等.聚乙二醇修饰的超顺磁性氧化铁纳米粒的制备及体外评价[J].中国药科大学学报,2013,44(4):316-320.
[6]何曼,刘颖,冯年平.金纳米粒及其在药物传递系统中的应用研究进展[J].药学进展,2013,37(12):623-627.
[7]Chellampillai B,Pawar A P.Improved bioavailability of orally administered andrographolide from p H-sensitive nanoparticles[J].Eur J Drug Metab Pharmacokinet,2011,35(3-4):123-129.
[8]Li Qi,Wang Yan,Feng Nianping,et al.Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma[J].J Drug Target,2008,16(10):725-732.
[9]Fan Junjun,Bi Long,Wu Tao,et al.A combined chitosan/nano-size hydroxyapatite system for the controlled release of icariin[J].J Mater Sci Mater Med,2012,23(2):399-407.
[10]Duan Xiaopin,Li Yaping.Hysicochemical characteristics of nanoparticles affect circulation,biodistribution,cellular internalization,and trafficking[J].Small,2013,9(9-10):1521-1532.
[11]郑爱萍,王奎书,郝睿,等.胸腺五肽p H-敏感壳聚糖纳米粒的制备、体外释放及生物活性[J].中国药学杂志,2007,42(9):679-685.
[12]Han Limei,Fu Yan,Cole A J,et al.Co-encapsulation and sustained-release of four components in ginkgo terpenes from injectable PELGE nanoparticles[J].Fitoterapia,2012,83(4):721-731.
[13]Md S,Ali M,Baboota S,et al.Preparation,characterization,in vivo biodistribution and pharmacokinetic studies of donepezilloaded PLGA nanoparticles for brain targeting[J].Drug Dev Ind Pharm,2014,40(2):278-287.
[14]Li H,Wen X S,Di W.In vitro and in vivo evaluation of triptolide-loaded pluronic P105 polymer micelles[J].Arzneimittelforschung,2012,62(7):340-344.
[15]Zhang C,Ding Y,Yu L L,et al.Polymeric micelle systems of hydroxycamptothecin based on amphiphilic N-alkyl-N-trimethyl chitosan derivatives[J].Colloids Surf B:Biointerfaces,2007,55(2):192-199.
[16]Yoncheva K,Calleja P,Agueros M,et al.Stabilized micelles as delivery vehicles for paclitaxel[J].Int J Pharm,2012,436(1-2):258-264.
[17]Zhao B X,Zhao Y,Huang Y,et al.The efficiency of tumorspecific p H-responsive peptide-modified polymeric micelles containing paclitaxel[J].Biomaterials,2012,33(8):2508-2520.
[18]Huang Xuan,Huang Xiong,Jiang Xiaohong,et al.In vitro antitumour activity of stearic acid-g-chitosan oligosaccharide polymeric micelles loading podophyllotoxin[J].J Microencapsul,2012,29(1):1-8.
[19]Kawano K,Watanabe M,Yamamoto T,et al.Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles[J].J Control Release,2006,112(3):329-332.
[20]Kwon S H,Kim S Y,Ha K W,et al.Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery[J].Arch Pharm Res,2007,30(9):1138-1143.
[21]Tsallas A,Jackson J,Burt H.The uptake of paclitaxel and docetaxel into ex vivo porcine bladder tissue from polymeric micelle formulations[J].Cancer Chemo Pharmacol,2011,68(2):431-444.
[22]Gill KK,Kaddoumi A,Nazzal S.Mixed micelles of PEG2000-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide:Enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer(NSCLC)cell lines[J].Eur J Pharm Sci,2012,46(1-2):64-71.
[23]Wang Feihu,Chen Yuxuan,Zhang Qian,et al.Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid micelles[J].Int J Nanomedicine,2012,7:325-337.
[24]Kalhapure R S,Akamanchi KG.Oleic acid based heterolipid synthesis,characterization and application in self-microemulsifying drug delivery system[J].Int J Pharm,2012,425(1-2):9-18.
[25]Ali KA,Mukhejee B,Bandyopadhyay AK.Formulation development and in vitro evaluation of solidified self-microemulsion in the form of tablet containing atorvastatin calcium[J].Drug Dev Ind Pharm,2013,39(11):1742-1749.
[26]Hu X,Lin C,Chen D,et al.Sirolimus solid self-microemulsifying pellets:Formulation development,characterization and bioavailability evaluation[J].Int J Pharm,2012,438(1-2):123-133.
[27]樊红波,王玉,刘昕,等.葛根黄酮自微乳化滴丸的制备及体外评价[J].特产研究,2014(3):44-47.
[28]Xi J,Chang Q,Chan C K,et al.Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid[J].AAPS Pharm Sci Tech,2009,10(1):172-182.
[29]Chen Y,Li G,Wu X,et al.Self-Microemulsifying Drug Delivery System(SMEDDS)of Vinpocetine:Formulation Development and in Vivo Assessment[J].Biol Pharm Bull,2008,31(1):118-125.
[30]Chen Z Q,Liu Y,Zhao J H,et al.Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system[J].Int J Nanomedicine,2012(7):1115-1125.
[31]Cho Y D,Park Y J.In vitro and in vivo evaluation of a self-microemulsifying drug delivery system for the poorly soluble drug fenofibrate[J].Arch Pharm Res,2014,37(2):193-203.
[32]Zhao Lili,Zhang Lin,Meng Lin,et al.Design and evaluation of a self-microemulsifying drug delivery system for apigenin[J].Drug Dev Ind Pharm,2012,39(5):662-669.
[33]Sermkaew N,Ketjinda W,Boonme P,et al.Liquid and solid self-microemulsifying drug delivery systems for improving the oral bioavailability of andrographolide from a crude extract of andrographis paniculata[J].Eur J Pharm Sci,2013,50(3-4):459-466.
[34]Lo Y L,Hsu C Y,Lin H R.p H-and thermo-sensitive pluronic/poly(acrylic acid)in situ hydrogels for sustained release of an anticancer drug[J].J Drug Target,2013,21(1):54-66.
[35]Chen En,Chen Jun,Cao Shilei,et al.Preparation of nasal temperature-sensitive in situ gel of Radix Bupleuri and evaluation of the febrile response mechanism[J].Drug Dev Ind Pharm,2010,36(4):490-496.
[36]Miyazaki S,Kubo W,Attwood D.Oral sustained delivery of theophylline using in-situ gelation of sodium alginate[J].J Control Release,2000,67(2-3):275-280.
[37]杨军宣,张海燕,周年化,等.栀子环烯醚萜苷鼻用原位凝胶的制备[J].中成药,2014,36(7):1402-1406.
[38]Lai Juiyang,Hsieh A C.A gelatin-g-poly(N-isopropylacrylamide)biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine[J].Biomaterials,2012,33(7):2372-2387.
[39]Yuan Y,Cui Y,Zhang L,et al.Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nimesulide[J].Int J Pharm,2012,430(1-2):114-119.
[40]Radivojsa M,Grabnar I,Ahlin Grabnar P.Thermoreversible in situ gelling poloxamer-based systems with chitosan nanocomplexes for prolonged subcutaneous delivery of heparin:Design and in vitro evaluation[J].Eur J Pharm Sci,2013,50(1):93-101.
[41]Sun Chuandi,Wang Ji,Liu Jianping,et al.Liquid Proliposomes of Nimodipine Drug Delivery System:Preparation,Characterization,and Pharmacokinetics[J].AAPS Pharm Sci Tech,2013,14(1):332-338.
[42]Chu Chang,Tong Shanshan,Xu Ying,et al.Proliposomes for oral delivery of dehydrosilymarin:preparation and evaluation in vitro and in vivo[J].Acta Pharmacol Sin,2011,32(7):973-980.
[43]Xiao Yanyu,Song Yunmei,Chen Zh-peng,et al.Preparation of silymarin proliposome:A new way to increase oral bioavailability of silymarin in beagle dogs[J].Inter J Pharm,2006,319(1-2):162-168.
[44]林薇,姚静,周建平.川陈皮素自组装前体脂质体的制备及其大鼠体内药代动力学研究[J].药学学报,2009,44(2):192-196.
[45]Zhao Liping,Hua Xiong,Peng Hailong,et al.PEG-coated lyophilized proliposomes:preparation,characterizations and in vitro release evaluation of vitamin E[J].Eur Food Res Technol,2011,232(4):647-654.
[46]蒲俊勇,吴酮,李勤耕.水溶性紫杉醇前体药物的合成及其药动学、药效学[J].光谱实验室,2013,30(2):995-999.
[47]Yu Lin,Chang Guangtao,Zhang Huan,et al.Injectable block copolymer hydrogels for sustained release of a PEGylated drug[J].Int J Pharm,2008,348(1-2):95-106.
[48]Greenwald RB,Conover CD,Pendri A,et al.Drug delivery of anticancer agents:water soluble 4-poly(ethylene glycol)derivatives of the lignan,podophyllotoxin[J].J Controlled Release,1999,61(3):281-294.
[49]Xie Zhigang,Guan Huili,Chen Xuesi,et al.A novel polymerpaclitaxel conjugate based on amphiphilic triblock copolymer[J].J Controlled Release,2007,117(2):210-216.
[2]张勇,高敏姣,张来芳,等.环孢素A白蛋白纳米粒的制备,体外释放及大鼠药代动力学评价[J].中国药科大学学报,2013,44(3):239-243.
[3]李楠,刘志东,范丽丽,等.黄岑素PLGA纳米粒的体外评价及细胞相容性研究[J].天津中医药大学学报,2014,33(1):28-31.
[4]耿丽娟,唐丽华,游本刚,等.α-常春藤皂苷丙烯酸树脂纳米粒的制备及其体外评价[J].中国药房,2013,22(3):367-372.
[5]周丽君,刘建平,熊非,等.聚乙二醇修饰的超顺磁性氧化铁纳米粒的制备及体外评价[J].中国药科大学学报,2013,44(4):316-320.
[6]何曼,刘颖,冯年平.金纳米粒及其在药物传递系统中的应用研究进展[J].药学进展,2013,37(12):623-627.
[7]Chellampillai B,Pawar A P.Improved bioavailability of orally administered andrographolide from p H-sensitive nanoparticles[J].Eur J Drug Metab Pharmacokinet,2011,35(3-4):123-129.
[8]Li Qi,Wang Yan,Feng Nianping,et al.Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma[J].J Drug Target,2008,16(10):725-732.
[9]Fan Junjun,Bi Long,Wu Tao,et al.A combined chitosan/nano-size hydroxyapatite system for the controlled release of icariin[J].J Mater Sci Mater Med,2012,23(2):399-407.
[10]Duan Xiaopin,Li Yaping.Hysicochemical characteristics of nanoparticles affect circulation,biodistribution,cellular internalization,and trafficking[J].Small,2013,9(9-10):1521-1532.
[11]郑爱萍,王奎书,郝睿,等.胸腺五肽p H-敏感壳聚糖纳米粒的制备、体外释放及生物活性[J].中国药学杂志,2007,42(9):679-685.
[12]Han Limei,Fu Yan,Cole A J,et al.Co-encapsulation and sustained-release of four components in ginkgo terpenes from injectable PELGE nanoparticles[J].Fitoterapia,2012,83(4):721-731.
[13]Md S,Ali M,Baboota S,et al.Preparation,characterization,in vivo biodistribution and pharmacokinetic studies of donepezilloaded PLGA nanoparticles for brain targeting[J].Drug Dev Ind Pharm,2014,40(2):278-287.
[14]Li H,Wen X S,Di W.In vitro and in vivo evaluation of triptolide-loaded pluronic P105 polymer micelles[J].Arzneimittelforschung,2012,62(7):340-344.
[15]Zhang C,Ding Y,Yu L L,et al.Polymeric micelle systems of hydroxycamptothecin based on amphiphilic N-alkyl-N-trimethyl chitosan derivatives[J].Colloids Surf B:Biointerfaces,2007,55(2):192-199.
[16]Yoncheva K,Calleja P,Agueros M,et al.Stabilized micelles as delivery vehicles for paclitaxel[J].Int J Pharm,2012,436(1-2):258-264.
[17]Zhao B X,Zhao Y,Huang Y,et al.The efficiency of tumorspecific p H-responsive peptide-modified polymeric micelles containing paclitaxel[J].Biomaterials,2012,33(8):2508-2520.
[18]Huang Xuan,Huang Xiong,Jiang Xiaohong,et al.In vitro antitumour activity of stearic acid-g-chitosan oligosaccharide polymeric micelles loading podophyllotoxin[J].J Microencapsul,2012,29(1):1-8.
[19]Kawano K,Watanabe M,Yamamoto T,et al.Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles[J].J Control Release,2006,112(3):329-332.
[20]Kwon S H,Kim S Y,Ha K W,et al.Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery[J].Arch Pharm Res,2007,30(9):1138-1143.
[21]Tsallas A,Jackson J,Burt H.The uptake of paclitaxel and docetaxel into ex vivo porcine bladder tissue from polymeric micelle formulations[J].Cancer Chemo Pharmacol,2011,68(2):431-444.
[22]Gill KK,Kaddoumi A,Nazzal S.Mixed micelles of PEG2000-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide:Enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer(NSCLC)cell lines[J].Eur J Pharm Sci,2012,46(1-2):64-71.
[23]Wang Feihu,Chen Yuxuan,Zhang Qian,et al.Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid micelles[J].Int J Nanomedicine,2012,7:325-337.
[24]Kalhapure R S,Akamanchi KG.Oleic acid based heterolipid synthesis,characterization and application in self-microemulsifying drug delivery system[J].Int J Pharm,2012,425(1-2):9-18.
[25]Ali KA,Mukhejee B,Bandyopadhyay AK.Formulation development and in vitro evaluation of solidified self-microemulsion in the form of tablet containing atorvastatin calcium[J].Drug Dev Ind Pharm,2013,39(11):1742-1749.
[26]Hu X,Lin C,Chen D,et al.Sirolimus solid self-microemulsifying pellets:Formulation development,characterization and bioavailability evaluation[J].Int J Pharm,2012,438(1-2):123-133.
[27]樊红波,王玉,刘昕,等.葛根黄酮自微乳化滴丸的制备及体外评价[J].特产研究,2014(3):44-47.
[28]Xi J,Chang Q,Chan C K,et al.Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid[J].AAPS Pharm Sci Tech,2009,10(1):172-182.
[29]Chen Y,Li G,Wu X,et al.Self-Microemulsifying Drug Delivery System(SMEDDS)of Vinpocetine:Formulation Development and in Vivo Assessment[J].Biol Pharm Bull,2008,31(1):118-125.
[30]Chen Z Q,Liu Y,Zhao J H,et al.Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system[J].Int J Nanomedicine,2012(7):1115-1125.
[31]Cho Y D,Park Y J.In vitro and in vivo evaluation of a self-microemulsifying drug delivery system for the poorly soluble drug fenofibrate[J].Arch Pharm Res,2014,37(2):193-203.
[32]Zhao Lili,Zhang Lin,Meng Lin,et al.Design and evaluation of a self-microemulsifying drug delivery system for apigenin[J].Drug Dev Ind Pharm,2012,39(5):662-669.
[33]Sermkaew N,Ketjinda W,Boonme P,et al.Liquid and solid self-microemulsifying drug delivery systems for improving the oral bioavailability of andrographolide from a crude extract of andrographis paniculata[J].Eur J Pharm Sci,2013,50(3-4):459-466.
[34]Lo Y L,Hsu C Y,Lin H R.p H-and thermo-sensitive pluronic/poly(acrylic acid)in situ hydrogels for sustained release of an anticancer drug[J].J Drug Target,2013,21(1):54-66.
[35]Chen En,Chen Jun,Cao Shilei,et al.Preparation of nasal temperature-sensitive in situ gel of Radix Bupleuri and evaluation of the febrile response mechanism[J].Drug Dev Ind Pharm,2010,36(4):490-496.
[36]Miyazaki S,Kubo W,Attwood D.Oral sustained delivery of theophylline using in-situ gelation of sodium alginate[J].J Control Release,2000,67(2-3):275-280.
[37]杨军宣,张海燕,周年化,等.栀子环烯醚萜苷鼻用原位凝胶的制备[J].中成药,2014,36(7):1402-1406.
[38]Lai Juiyang,Hsieh A C.A gelatin-g-poly(N-isopropylacrylamide)biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine[J].Biomaterials,2012,33(7):2372-2387.
[39]Yuan Y,Cui Y,Zhang L,et al.Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nimesulide[J].Int J Pharm,2012,430(1-2):114-119.
[40]Radivojsa M,Grabnar I,Ahlin Grabnar P.Thermoreversible in situ gelling poloxamer-based systems with chitosan nanocomplexes for prolonged subcutaneous delivery of heparin:Design and in vitro evaluation[J].Eur J Pharm Sci,2013,50(1):93-101.
[41]Sun Chuandi,Wang Ji,Liu Jianping,et al.Liquid Proliposomes of Nimodipine Drug Delivery System:Preparation,Characterization,and Pharmacokinetics[J].AAPS Pharm Sci Tech,2013,14(1):332-338.
[42]Chu Chang,Tong Shanshan,Xu Ying,et al.Proliposomes for oral delivery of dehydrosilymarin:preparation and evaluation in vitro and in vivo[J].Acta Pharmacol Sin,2011,32(7):973-980.
[43]Xiao Yanyu,Song Yunmei,Chen Zh-peng,et al.Preparation of silymarin proliposome:A new way to increase oral bioavailability of silymarin in beagle dogs[J].Inter J Pharm,2006,319(1-2):162-168.
[44]林薇,姚静,周建平.川陈皮素自组装前体脂质体的制备及其大鼠体内药代动力学研究[J].药学学报,2009,44(2):192-196.
[45]Zhao Liping,Hua Xiong,Peng Hailong,et al.PEG-coated lyophilized proliposomes:preparation,characterizations and in vitro release evaluation of vitamin E[J].Eur Food Res Technol,2011,232(4):647-654.
[46]蒲俊勇,吴酮,李勤耕.水溶性紫杉醇前体药物的合成及其药动学、药效学[J].光谱实验室,2013,30(2):995-999.
[47]Yu Lin,Chang Guangtao,Zhang Huan,et al.Injectable block copolymer hydrogels for sustained release of a PEGylated drug[J].Int J Pharm,2008,348(1-2):95-106.
[48]Greenwald RB,Conover CD,Pendri A,et al.Drug delivery of anticancer agents:water soluble 4-poly(ethylene glycol)derivatives of the lignan,podophyllotoxin[J].J Controlled Release,1999,61(3):281-294.
[49]Xie Zhigang,Guan Huili,Chen Xuesi,et al.A novel polymerpaclitaxel conjugate based on amphiphilic triblock copolymer[J].J Controlled Release,2007,117(2):210-216.