可注射甘油磷酸钠-壳聚糖/海藻酸钠复合水凝胶的制备及性能研究
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摘要
通过物理交联方法,将海藻酸钠(SA)与甘油磷酸钠-壳聚糖(GP-CS)复合制备可注射GP-CS/SA复合水凝胶,考察了物料比(GP-CS与SA的质量比)对复合水凝胶凝胶化时间、溶胶含量、微观形态、热稳定性、平衡溶胀等物理化学性能的影响。结果表明,复合水凝胶中SA比例越大,凝胶化时间越短,溶胶含量越少;扫描电镜和红外光谱分析表明,GP-CS与SA通过物理交联形成三维网络结构的水凝胶;热重分析表明,复合水凝胶与GP-CS水凝胶的热稳定性没有很显著差异;平衡溶胀实验表明,随着SA比例的增大,复合水凝胶的溶胀率和平衡溶胀率升高。GP-CS/SA复合水凝胶比单一的GP-CS水凝胶具有更高的机械强度、更好的吸水性和平衡溶胀性能。
Using sodium alginate(SA)and sodium glycerophosphate-chitosan(GP-CS)as raw materials,we prepared injectable GP-CS/SA composite hydrogel by aphysical crossing method.Meanwhile,we investigated the effects of material ratio(the mass ratio of GP-CS and SA)on gelation time,sol content,micromorphology,thermal stability,and equilibrium swelling of composite hydrogel.The results show that the larger the SA proportion in the composite hydrogel is,the shorter the gelation time and the less the sol content will be.The SEM image and FTIR spectrum indicate that GP-CS/SA composite hydrogel has three-dimensional network structure through the physical crossing reaction of GP-CS with SA.Moreover,the thermogravimetric analysis shows that there is no significant difference between the thermal stability of composite hydrogel and GP-CS hydrogel.Furthermore,the equilibrium swelling experiment indicates that the swelling rate and the equilibrium swelling rate increase with the increase of SA proportion.The GP-CS/SA composite hydrogel has higher mechanical strength than single GP-CS hydrogel,and has better water absorption and equilibrium swelling property.
Using sodium alginate(SA)and sodium glycerophosphate-chitosan(GP-CS)as raw materials,we prepared injectable GP-CS/SA composite hydrogel by aphysical crossing method.Meanwhile,we investigated the effects of material ratio(the mass ratio of GP-CS and SA)on gelation time,sol content,micromorphology,thermal stability,and equilibrium swelling of composite hydrogel.The results show that the larger the SA proportion in the composite hydrogel is,the shorter the gelation time and the less the sol content will be.The SEM image and FTIR spectrum indicate that GP-CS/SA composite hydrogel has three-dimensional network structure through the physical crossing reaction of GP-CS with SA.Moreover,the thermogravimetric analysis shows that there is no significant difference between the thermal stability of composite hydrogel and GP-CS hydrogel.Furthermore,the equilibrium swelling experiment indicates that the swelling rate and the equilibrium swelling rate increase with the increase of SA proportion.The GP-CS/SA composite hydrogel has higher mechanical strength than single GP-CS hydrogel,and has better water absorption and equilibrium swelling property.
引文
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[2] 赵丽,王萍.甲壳素和壳聚糖在水处理中的应用[J].化工环保,2003,23(4):213-215.ZHAO L,WANG P.Application of chitin and chitosan in water treatment[J].Environmental Protection of Chemical Industry,2003,23(4):213-215.
[3] 李维静.甲壳素、壳聚糖的性质、制备及其在食品中的应用[J].安徽农学通报,2007,13(10):58-60.
[4] 郭开宇,赵谋明.甲壳素/壳聚糖的研究进展及其在食品工业中的应用[J].食品与发酵工业,2000,26(1):59-64.GUO K Y,ZHAO M M.The progress in chitin/chitosan research and its applications in food industry[J].Food and Fermentation Industries,2000,26(1):59-64.
[5] 廖戎.甲壳素制备壳聚糖脱乙酰度可控性的研究[J].四川化工,2007,10(2):14-17.LIAO R.The controllable degree of deacetylation and molecular weight prepare chitosan from chitin[J].Sichuan Chemical Industry,2007,10(2):14-17.
[6] 汪小乐,简晓顺,庞廷媛,等.叶酸偶联壳聚糖载多西他赛纳米粒的制备[J].中国药房,2014,25(29):2740-2743.WANG X L,JIAN X S,PANG T Y,et al.Preparation of docetaxel-loaded folate-conjugated chitosan nanoparticles[J].China Pharmacy,2014,25(29):2740-2743.
[7] 位晓娟,张长青,顾其胜.壳聚糖的性能、产品及应用[J].中国修复重建外科杂志,2010,24(10):1265-1270.WEI X J,ZHANG C Q,GU Q S.Properties,products,and applications of chitosan[J].Chinese Journal of Reparative and Reconstructive Surgery,2010,24(10):1265-1270.
[8] 车小琼,孙庆申,赵凯.甲壳素和壳聚糖作为天然生物高分子材料的研究进展[J].高分子通报,2008(2):45-49.CHE X Q,SUN Q S,ZHAO K.Progress in the research on chitin and chitosan as natural biopolymer[J].Chinese Polymer Bulletin,2008(2):45-49.
[9] 曹维强,王静,陈鹏.壳聚糖的构效关系及其在食品工业中的应用[J].食品研究与开发,2006,27(5):165-168.CAO W Q,WANG J,CHEN P.The relationship of chitosan and functional properties and its application in food industry[J].Food Research and Development,2006,27(5):165-168.
[10] 姚远,胡巧玲,谌凯.壳聚糖三维材料的制备及其应用研究进展[J].科技通报,2012,28(5):1-8,13.YAO Y,HU Q L,SHEN K.Progress in the preparation of threedimensional chitosan material[J].Bulletin of Science and Technology,2012,28(5):1-8,13.
[11] 王明力.具有抗菌功能的壳聚糖复合膜研究及应用[D].贵阳:贵州大学,2008.
[12] 孙斌,刘洪臣.可注射温敏壳聚糖/甘油磷酸钠基水凝胶在医学中应用进展[J].中华老年口腔医学杂志,2011,9(1):46-49.
[13] 章永望,赵会英,张娜.新型可注射温敏水凝胶的制备及其释药性能[J].北京化工大学学报,2007,34(5):535-539.ZHANG Y W,ZHAO H Y,ZHANG N.Thermo-oxidative aging mechanisms of carbon fiber/epoxy resin compound materials[J].Journal of Beijing University of Chemical Technology,2007,34(5):535-539.
[14] 魏宏亮,王连才,张爱英,等.可注射水凝胶的制备与应用[J].化学进展,2004,16(6):1008-1016.WEI H L,WANG L C,ZHANG A Y,et al.Preparation and applications of injectable hydrogels[J].Progress in Chemistry,2004,16(6):1008-1016.
[15] 王康,何志敏.海藻酸钠与钙或锌离子吸附平衡过程研究[J].化学工程,2004,32(4):5-7,17.WANG K,HE Z M.Study on adsorption equilibrium process of sodium alginate with calcium ions or zinc ions[J].Chemical Engineering,2004,32(4):5-7,17.
[16] 李红兵.海藻酸钠理化性质研究和特种品种制备[D].天津:天津大学,2005.LI H B.On the physicochemical properties of sodium alginate and preparation of its special specimens[D].Tianjin:Tianjin University,2005.
[17] 王淑勤,肖乐勤.热重分析曲线影响因素的研究与探索[J].河北化工,2005(4):78-79.