表面拉曼增强效应在生物医药检测中的应用
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摘要
目的综述近年来的表面拉曼增强光谱在生物样品和药物检测方面的应用成果和研究进展。方法大量搜集最近几年国内外关于表面拉曼研究和应用的相关文献报道,尤其是有关生物医药方面的检测,从中归纳出表面拉曼的研究应用的现况并对其前景做出推断。结果表面拉曼增强光谱已成为分子领域检测技术的研究热点,在生物样品的检测方面,对蛋白质、核酸、药物等都具有很好的应用潜力;在实际应用的过程中,检测技术和理论在不断进步,应用的方向一直在适应人类生理和社会的需要。结论表面拉曼增强光谱由于其独特的优势,目前在生物医药检测中的运用越来越广泛,并显示出良好的研究和应用前景。
Objective To summarize the progress and application of surface-enhanced Raman scattering(SERS)in the detection of biological and pharmaceutical samples.Methods Documents or reports related to applying SERS to the detection of biological and pharmaceutical samples were reviewed and compared.Results SERS has become a detection technique in biomolecule field,which shows great potentiality to detect proteins,nucleic acids,drugs and so on.During the process of its application,the technology and theory of SERS are being improved to meet the humans′and social demands at the same time.Conclusion In recent years,the latest progress in research and application of SERS to the detection of biological and pharmaceutical samples has been made and its good prospects have been exhibited because of its unique advantages.
Objective To summarize the progress and application of surface-enhanced Raman scattering(SERS)in the detection of biological and pharmaceutical samples.Methods Documents or reports related to applying SERS to the detection of biological and pharmaceutical samples were reviewed and compared.Results SERS has become a detection technique in biomolecule field,which shows great potentiality to detect proteins,nucleic acids,drugs and so on.During the process of its application,the technology and theory of SERS are being improved to meet the humans′and social demands at the same time.Conclusion In recent years,the latest progress in research and application of SERS to the detection of biological and pharmaceutical samples has been made and its good prospects have been exhibited because of its unique advantages.
引文
[1]冯尚源,陈荣,李永增,等.党参煎剂表面增强拉曼光谱[J].中国激光,2010,37(1):121-124.
[2]杨昌虎,曾晓英,袁剑辉.激光拉曼光谱在水质分析中的应用[J].中国激光,2008,35(8):1169-1172.
[3]林文硕,陈荣,李永增,等.山药近红外拉曼光谱分析[J].光谱学与光谱分析,2008,28(5):1095-1097.
[4]高泽红,于晶功,刘福祥,等.结直肠癌组织中脂类伸缩振动的拉曼光谱[J].中国激光,2010,37(2):605-608.
[5]Feng Shangyuan,Pan Jianji,Wu Yan′an,et al.Study on gastric cancer blood plasma based on surface-enhanced Raman spectroscopy combined with multivariate analysis[J].Sci China Life Sci,2011,54(9):828-834.
[6]Fleischman M,Hendra P J,McQuillan A J.Raman spectra of pyridine adsorbed at a silver electrode[J].Chem Phys Lett,1974,26:163-166.
[7]Jeanmaire D L,Van Duyne R P.Surface Raman spectroelectrochemistry:PartⅠ.heterocyelic,aromatic,and aliphatic amines adsorbed on the anodized silver electrode[J].J Electron Chem,1977,84(1):1-20.
[8]Albrecht M G,Creighton J A.Anomalously intense Raman spectra of pyridine at a silver electrode[J].J Am Chem Soc,1977,99(15):5215-5217.
[9]席刚琴,陈燕坪,陈刚,等.基于表面增强拉曼光谱的结肠癌组织免疫分析[J].中国激光,2011,38(9):91-96.
[10]Janelle M Reyes-Goddard MSc,Hugh Barr,Nicholas Stone.Photodiagnosis using Raman and surface enhanced Raman scattering of bodily fluids[J].Photodiagn Photodyn Ther,2005,2:223-233.
[11]韩洪文,班戈,李珂.皮疹病人血清的表面增强拉曼光谱[J].光谱学与光谱分析,2010,30(1):102-104.
[12]Juan Hu,Peng-Cheng Zheng,Jian-Hui Jiang,et al.Electrostatic interaction based approach to thrombin detection by surface-enhanced Raman spectroscopy[J].Anal Chem,2009,81(1):87-93.
[13]Ming Li,Scott K Cushing,Jianming Zhang,et al.Three-dimensional hierarchical plasmonic nano-architecture enhanced surface-enhanced Raman scattering immunosensor for cancer biomarker detection in blood plasma[J].ACS Nano,2013,7(6):4967-4976.
[14]Ruben Ahijado-Guzman,Paulino Go mez-Puertas,Ramon A Alvarez-Puebla,et al.Surface-enhanced Raman scattering-based detection of the interactions between the essential cell division FtsZ protein and bacterial membrane elements[J].ACS Nano,2012,6(8):7514-7520.
[15]Gufeng Wang,Robert J Lipert,Maneesh Jain,et al.Detection of the potential pancreatic cancer marker MUC4in serum using surface-enhanced Raman scattering[J].Anal Chem,2011,83:2554-2561.
[16]Gang Chen,Yanping Chen,Xiongwei Zheng,et al.Surface-enhanced Raman scattering study of carcinoembryonic antigen in serum from patients with colorectal cancers[J].Appl Phys B,2013,4(113):597-602.
[17]Ping Wu,Yang Gao,Hui Zhang,et al.Aptamerguided silver-gold bimetallic nanostructures with highly active surface-enhanced Raman scattering for specific detection and near-infrared photothermal therapy of human breast cancer cells[J].Anal Chem,2012,84:7692-7699.
[18]Christina M MacLaughlin,Nisa Mullaithilaga,Guisheng Yang,et al.Surface-enhanced Raman scattering dye-labeled Au nanoparticles for triplexed detection of leukemia and lymphoma cells and SERS flow cytometry[J].Langmuir,2013,29:1908-1919.
[19]Hu Juan,Zhang Chunyang.Surface-enhanced Raman scattering technology and its application to gene analysis[J].Prog Chem,2010,22(8):1641-1647.
[20]Justin L Abell,Jeonifer M Garren,Jeremy D Driskell,et al.Label-free detection of micro-RNA hybridization using surface-enhanced Raman spectroscopy and leastsquares analysis[J].J Am Chem Soc,2012,134(31):12889-12892.
[21]Aoune Barhoumi,Naomi J Halas.Detecting chemically modified DNA bases using surface-enhanced Raman spectroscopy[J].J Phys Chem Lett,2011,2(24):3118-3123.
[22]Ming Li,Scott K Cushing,Hongyan Liang,et al.Plasmonic nanorice antenna on triangle nanoarray for surface-enhanced Raman scattering detection of hepatitis B virus DNA[J].Anal Chem,2013,85(4):2072-2078.
[23]代剑华,彭贵勇,冉曾令,等.胃黏膜正常和癌变细胞基因组DNA的表面增强拉曼光谱研究[N].激光生物学报,2011,20(3):299-303.
[24]Sajanlal R Panikkanvalappil,Megan A Mackey,Mostafa A El-Sayed.Probing the unique dehydration-induced structural modifications in cancer cell DNA using surface enhanced Raman spectroscopy[J].J Am Chem Soc,2013,135(12):4815-4821.
[25]崔颜,任斌,田中群.基于纳米技术的表面增强拉曼光谱在细胞研究中的应用[N].东南大学学报:医学版,2011,30(1):254-262.
[26]He L,Deen B,Rodda T,et al.Rapid detection of ricin in milk using immunomagnetic separation combined with surface-enhanced Raman spectroscopy[J].J Food Sci,2011,76(5):49-53.
[27]常春,焦媛媛,方琪,等.蓖麻中毒与检测方法的研究进展[J].西北药学杂志,2012,27(4):394-397.
[28]Ming Li,Jianming Zhang,Savan Suri,et al.Detection of adenosine triphosphate with an aptamer biosensor based on surface-enhanced Raman scattering[J].Anal Chem,2012,84(6):2837-2842.
[29]Ansoon Kim,Steven J Barcelo,R Stanley Williams,et al.Melamine sensing in milk products by using surface enhanced Raman scattering[J].Anal Chem,2012,84(21):9303-9309.
[30]Yingyue Zhu,Hua Kuang,Liguang Xu,et al.Gold nanorod assembly based approach to toxin detection by SERS[J].J Mater Chem,2012,22(6):2387-2391.
[31]余国滔.拉曼光谱在医学上的应用(Ⅱ)[N].光散射学报,1996,8(3):174-183.
[32]Clement Yuen,Wei Zheng,Zhiwei Huang.Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates[J].Biosens Bioelectron,2010,26(2):580-584.
[33]Andrea Lucottia,Matteo Tommasinia,Michele Casellab,et al.TLC-surface enhanced Raman scattering of apomorphine in human plasma[J].Vib Spectrosc,2012,62:286-291.
[34]Stuart Farquharson a,Alan D Gift,Chetan Shende,et al.Detection of 5-fluorouracil in saliva using surface-enhanced Raman spectroscopy[J].Vib Spectrosc,2005,38:79-84.
[35]Igor Chourpa,Simone Cohen-Jonathan,Pierre Dubois.Mapping chemical and structural composition of pharmaceutical and biological samples by Raman,surface-enhanced Raman and fluorescence spectral imaging[J].Springer Ser Opt Sci,2012,168:243-255.
[36]Jing Yang,Yiping Cui,Shenfei Zong,et al.Tracking multiplex drugs and their dynamics in living cells using the label-free surface-enhanced Raman scattering technique[J].Mol Pharmaceutics,2012,9(4):842-849.
[37]Shenfei Zong,Zhuyuan Wang,Hui Chen,et al.Surface enhanced Raman scattering traceable and glutathione responsive nanocarrier for the intracellular drug delivery[J].Anal Chem,2013,85(4):2223-2230.
[38]Zhai Fu-Li,Huang Yi-Qun,Wang Xi-Chang,et al.Surface-enhanced Raman spectroscopy for rapid determination ofβ-agonists in swine urine[J].Chin J Anal Chem,2012,40(5):718-723.
[39]Chrysafis Andreou,Mehran R Hoonejani,Meysam R Barmi,et al.Rapid detection of drugs of abuse in saliva using surface enhanced Raman spectroscopy and microfluidics[J].ACS Nano,2013,7(8):7157-7164.
[40]Anne Mrz,Bettina Mnch,Petra Rsch,et al.Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy(LOC-SERS)[J].Anal Bioanal Chem,2011,400:2755-2761.
[41]Murat Kaya,Mürvet Volkan.New approach for the surface enhanced resonance Raman scattering(SERRS)detection of dopamine at picomolar(pM)levels in the presence of ascorbic acid[J].Anal Chem,2012,84:7729-7735.
[42]曾焕俊,韩莹,李莹,等.注射液拉曼光谱图谱制备及影响因素研究[J].今日药学,2011,21(3):170-173.
[43]黄浩,陈荣,陈伟炜,等.黄芪表面增强拉曼光谱研究[J].北京中医药大学学报,2012,35(12):843-847.
[44]梁瑾,封士兰,刘小花,等.黄芪药材的高效液相色谱指纹图谱及主要成分的含量测定方法研究进展[J].西北药学杂志,2012,27(5):490-493.
[2]杨昌虎,曾晓英,袁剑辉.激光拉曼光谱在水质分析中的应用[J].中国激光,2008,35(8):1169-1172.
[3]林文硕,陈荣,李永增,等.山药近红外拉曼光谱分析[J].光谱学与光谱分析,2008,28(5):1095-1097.
[4]高泽红,于晶功,刘福祥,等.结直肠癌组织中脂类伸缩振动的拉曼光谱[J].中国激光,2010,37(2):605-608.
[5]Feng Shangyuan,Pan Jianji,Wu Yan′an,et al.Study on gastric cancer blood plasma based on surface-enhanced Raman spectroscopy combined with multivariate analysis[J].Sci China Life Sci,2011,54(9):828-834.
[6]Fleischman M,Hendra P J,McQuillan A J.Raman spectra of pyridine adsorbed at a silver electrode[J].Chem Phys Lett,1974,26:163-166.
[7]Jeanmaire D L,Van Duyne R P.Surface Raman spectroelectrochemistry:PartⅠ.heterocyelic,aromatic,and aliphatic amines adsorbed on the anodized silver electrode[J].J Electron Chem,1977,84(1):1-20.
[8]Albrecht M G,Creighton J A.Anomalously intense Raman spectra of pyridine at a silver electrode[J].J Am Chem Soc,1977,99(15):5215-5217.
[9]席刚琴,陈燕坪,陈刚,等.基于表面增强拉曼光谱的结肠癌组织免疫分析[J].中国激光,2011,38(9):91-96.
[10]Janelle M Reyes-Goddard MSc,Hugh Barr,Nicholas Stone.Photodiagnosis using Raman and surface enhanced Raman scattering of bodily fluids[J].Photodiagn Photodyn Ther,2005,2:223-233.
[11]韩洪文,班戈,李珂.皮疹病人血清的表面增强拉曼光谱[J].光谱学与光谱分析,2010,30(1):102-104.
[12]Juan Hu,Peng-Cheng Zheng,Jian-Hui Jiang,et al.Electrostatic interaction based approach to thrombin detection by surface-enhanced Raman spectroscopy[J].Anal Chem,2009,81(1):87-93.
[13]Ming Li,Scott K Cushing,Jianming Zhang,et al.Three-dimensional hierarchical plasmonic nano-architecture enhanced surface-enhanced Raman scattering immunosensor for cancer biomarker detection in blood plasma[J].ACS Nano,2013,7(6):4967-4976.
[14]Ruben Ahijado-Guzman,Paulino Go mez-Puertas,Ramon A Alvarez-Puebla,et al.Surface-enhanced Raman scattering-based detection of the interactions between the essential cell division FtsZ protein and bacterial membrane elements[J].ACS Nano,2012,6(8):7514-7520.
[15]Gufeng Wang,Robert J Lipert,Maneesh Jain,et al.Detection of the potential pancreatic cancer marker MUC4in serum using surface-enhanced Raman scattering[J].Anal Chem,2011,83:2554-2561.
[16]Gang Chen,Yanping Chen,Xiongwei Zheng,et al.Surface-enhanced Raman scattering study of carcinoembryonic antigen in serum from patients with colorectal cancers[J].Appl Phys B,2013,4(113):597-602.
[17]Ping Wu,Yang Gao,Hui Zhang,et al.Aptamerguided silver-gold bimetallic nanostructures with highly active surface-enhanced Raman scattering for specific detection and near-infrared photothermal therapy of human breast cancer cells[J].Anal Chem,2012,84:7692-7699.
[18]Christina M MacLaughlin,Nisa Mullaithilaga,Guisheng Yang,et al.Surface-enhanced Raman scattering dye-labeled Au nanoparticles for triplexed detection of leukemia and lymphoma cells and SERS flow cytometry[J].Langmuir,2013,29:1908-1919.
[19]Hu Juan,Zhang Chunyang.Surface-enhanced Raman scattering technology and its application to gene analysis[J].Prog Chem,2010,22(8):1641-1647.
[20]Justin L Abell,Jeonifer M Garren,Jeremy D Driskell,et al.Label-free detection of micro-RNA hybridization using surface-enhanced Raman spectroscopy and leastsquares analysis[J].J Am Chem Soc,2012,134(31):12889-12892.
[21]Aoune Barhoumi,Naomi J Halas.Detecting chemically modified DNA bases using surface-enhanced Raman spectroscopy[J].J Phys Chem Lett,2011,2(24):3118-3123.
[22]Ming Li,Scott K Cushing,Hongyan Liang,et al.Plasmonic nanorice antenna on triangle nanoarray for surface-enhanced Raman scattering detection of hepatitis B virus DNA[J].Anal Chem,2013,85(4):2072-2078.
[23]代剑华,彭贵勇,冉曾令,等.胃黏膜正常和癌变细胞基因组DNA的表面增强拉曼光谱研究[N].激光生物学报,2011,20(3):299-303.
[24]Sajanlal R Panikkanvalappil,Megan A Mackey,Mostafa A El-Sayed.Probing the unique dehydration-induced structural modifications in cancer cell DNA using surface enhanced Raman spectroscopy[J].J Am Chem Soc,2013,135(12):4815-4821.
[25]崔颜,任斌,田中群.基于纳米技术的表面增强拉曼光谱在细胞研究中的应用[N].东南大学学报:医学版,2011,30(1):254-262.
[26]He L,Deen B,Rodda T,et al.Rapid detection of ricin in milk using immunomagnetic separation combined with surface-enhanced Raman spectroscopy[J].J Food Sci,2011,76(5):49-53.
[27]常春,焦媛媛,方琪,等.蓖麻中毒与检测方法的研究进展[J].西北药学杂志,2012,27(4):394-397.
[28]Ming Li,Jianming Zhang,Savan Suri,et al.Detection of adenosine triphosphate with an aptamer biosensor based on surface-enhanced Raman scattering[J].Anal Chem,2012,84(6):2837-2842.
[29]Ansoon Kim,Steven J Barcelo,R Stanley Williams,et al.Melamine sensing in milk products by using surface enhanced Raman scattering[J].Anal Chem,2012,84(21):9303-9309.
[30]Yingyue Zhu,Hua Kuang,Liguang Xu,et al.Gold nanorod assembly based approach to toxin detection by SERS[J].J Mater Chem,2012,22(6):2387-2391.
[31]余国滔.拉曼光谱在医学上的应用(Ⅱ)[N].光散射学报,1996,8(3):174-183.
[32]Clement Yuen,Wei Zheng,Zhiwei Huang.Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates[J].Biosens Bioelectron,2010,26(2):580-584.
[33]Andrea Lucottia,Matteo Tommasinia,Michele Casellab,et al.TLC-surface enhanced Raman scattering of apomorphine in human plasma[J].Vib Spectrosc,2012,62:286-291.
[34]Stuart Farquharson a,Alan D Gift,Chetan Shende,et al.Detection of 5-fluorouracil in saliva using surface-enhanced Raman spectroscopy[J].Vib Spectrosc,2005,38:79-84.
[35]Igor Chourpa,Simone Cohen-Jonathan,Pierre Dubois.Mapping chemical and structural composition of pharmaceutical and biological samples by Raman,surface-enhanced Raman and fluorescence spectral imaging[J].Springer Ser Opt Sci,2012,168:243-255.
[36]Jing Yang,Yiping Cui,Shenfei Zong,et al.Tracking multiplex drugs and their dynamics in living cells using the label-free surface-enhanced Raman scattering technique[J].Mol Pharmaceutics,2012,9(4):842-849.
[37]Shenfei Zong,Zhuyuan Wang,Hui Chen,et al.Surface enhanced Raman scattering traceable and glutathione responsive nanocarrier for the intracellular drug delivery[J].Anal Chem,2013,85(4):2223-2230.
[38]Zhai Fu-Li,Huang Yi-Qun,Wang Xi-Chang,et al.Surface-enhanced Raman spectroscopy for rapid determination ofβ-agonists in swine urine[J].Chin J Anal Chem,2012,40(5):718-723.
[39]Chrysafis Andreou,Mehran R Hoonejani,Meysam R Barmi,et al.Rapid detection of drugs of abuse in saliva using surface enhanced Raman spectroscopy and microfluidics[J].ACS Nano,2013,7(8):7157-7164.
[40]Anne Mrz,Bettina Mnch,Petra Rsch,et al.Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy(LOC-SERS)[J].Anal Bioanal Chem,2011,400:2755-2761.
[41]Murat Kaya,Mürvet Volkan.New approach for the surface enhanced resonance Raman scattering(SERRS)detection of dopamine at picomolar(pM)levels in the presence of ascorbic acid[J].Anal Chem,2012,84:7729-7735.
[42]曾焕俊,韩莹,李莹,等.注射液拉曼光谱图谱制备及影响因素研究[J].今日药学,2011,21(3):170-173.
[43]黄浩,陈荣,陈伟炜,等.黄芪表面增强拉曼光谱研究[J].北京中医药大学学报,2012,35(12):843-847.
[44]梁瑾,封士兰,刘小花,等.黄芪药材的高效液相色谱指纹图谱及主要成分的含量测定方法研究进展[J].西北药学杂志,2012,27(5):490-493.