摘要
目的分析多索茶碱与布地奈德联合治疗急性发作的支气管哮喘效果。方法选取支气管哮喘急性发作患者134例,随机分为两组,各67例。对照组给予布地奈德吸入,2吸(200μg)/次,2次/d;在此基础上,观察组给予多索茶碱片口服,200μg(1片)/次,2次/d。观察比较两组治疗前后FEV1、FVC、FEV1/FVC及IL-23、总有效率及不良反应发生情况。结果观察组总有效率为94.0%,显著高于对照组的82.1%(P<0.05),而口干、恶心、呕吐、面红等总发生率为10.4%,与对照组的7.5%比较,差异无统计学意义。治疗前两组FEV1/FVC等指标及血清IL-23水平比较,差异无统计学意义;治疗后两组均显著改善,且观察组改善幅度较大,组间比较差异有统计学意义(P<0.05)。结论对于支气管哮喘急性发作患者,多索茶碱与布地奈德联合有着显著效果,且口干、恶心、呕吐、面红等发生率增加不明显,值得推广。
Objective To observe the clinical efficacy of doxofylline combined with budesonide on the treatment of bronchial asthma.Methods134 patients with bronchial asthma were randomly distributed into two groups.Control group(67 patients) was treated withbudesonide,and observation group(67 patients) was treated with doxofylline on the base of controlgroup.The treated time of two groups was 14 days.The total effective rate,changes of lung function and IL-23,and incidences of adverse effect were observed.Results The total effective rate of observation group was94.0%,and control group was 82.1%.There was a significant difference between the groups.The pulmonary function and IL-23 after treatment in observation group was more relieved than that of controlgroup after treatment.The incidences of adverse effect in observation group was 10.4%,and control group was 7.5%.There was no significant difference between the groups.Conclusion The treatment of doxofylline combined with budesonide on the treatment of bronchial asthma had a good effect and more safety,and worthy to be popularized.
引文
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