中心体的结构与组装
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摘要
在动物细胞中,中心体是最主要的微管组织中心,对细胞运动和极性、纤毛生长以及细胞分裂都具有重要作用。该文总结了中心体的结构组成、组装过程,并具体阐述了中心体关键结构的组装等方面的研究进展,为更深入地了解中心体组装的过程及调控机制提供参考。
In animal cells, centrosome is the major microtubule organizing center(MTOC), which plays important role in cell motility and polarity, cilia biogenesis and cytokinesis. Here we summarize the centrosome structure, centrosome duplication process, and recent adavances in the assembly of centrosome key components,which may provide some cues in further study of centrosome assembly and the underlying regulation mechanism.
In animal cells, centrosome is the major microtubule organizing center(MTOC), which plays important role in cell motility and polarity, cilia biogenesis and cytokinesis. Here we summarize the centrosome structure, centrosome duplication process, and recent adavances in the assembly of centrosome key components,which may provide some cues in further study of centrosome assembly and the underlying regulation mechanism.
引文
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2 Fu J,Hagan IM,Glover DM.The centrosome and its duplication cycle.Cold Spring Harb Perspect Biol 2015;7(2):a015800.
3 Carvalho-Santos Z,Azimzadeh J,Pereira-Leal JB,BettencourtDias M.Evolution:Tracing the origins of centrioles,cilia,and flagella.J Cell Biol 2011;194(2):165-75.
4 Huang N,Xia YQ,Zhang DH,Wang S,Bao YT,He RS,et al.Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68.Nat Commun2017;doi:10.1038/ncomms15057.
5 Muller H,Fogeron ML,Lehmann V,Lehrach H,Lange BMH.Acentrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint.Science 2006;314(5799):654-7.
6 Xia YQ,Huang N,Chen ZQ,Li FY,Fan GL,Ma DD,et al.CCDC102B functions in centrosome linker assembly and centrosome cohesion.J Cell Sci 2018;doi:10.1242/jcs.222901.
7 Anderson RG.The three-dimensional structure of the basal body from the rhesus monkey oviduct.J Cell Biol 1972;54(2):246-65.
8 Yang TT,Chong WM,Wang WJ,Mazo G,Tanos B,Chen ZM,et al.Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components.Nat Commun 2018;9(1):2023.
9 Tanos BE,Yang HJ,Soni R,Wang WJ,Macaluso FP,Asara JM,et al.Centriole distal appendages promote membrane docking,leading to cilia initiation.Genes Dev 2013;27(2):163-8.
10 Kobayashi T,Dynlacht BD.Regulating the transition from centriole to basal body.J Cell Biol 2011;193(3):435-44.
11 Garcia-Gonzalo FR,Reiter JF.Scoring a backstage pass:mechanisms of ciliogenesis and ciliary access.J Cell Biol 2012;197(6):697-709.
12 Tateishi K,Yamazaki Y,Nishida T,Watanabe S,Kunimoto K,Ishikawa H,et al.Two appendages homologous between basal bodies and centrioles are formed using distinct Odf2 domains.JCell Biol 2013;203(3):417-25.
13 Debrabander M,Geuens G,Nuydens R,Willebrords R,Demey J.Microtubule stability and assembly in living cells-the influence of metabolic-inhibitors,taxol and Ph.Cold Spring Harb Sym1981;46(Pt 1):227-40.
14 Gorgidze LA,Vorobjev IA.Centrosome and microtubules behavior in the cytoplasts.J Submicr Cytol Path 1995;27(3):381-9.
15 Piel M,Meyer P,Khodjakov A,Rieder CL,Bornens M.The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells.J Cell Biol2000;149(2):317-29.
16 Delgehyr N,Sillibourne J,Bornens M.Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function.J Cell Sci 2005;118(Pt 8):1565-75.
17 Monnich M,Borgeskov L,Breslin L,Jakobsen L,Rogowski M,Doganli C,et al.CEP128 localizes to the subdistal appendages of the mother centriole and regulates TGF-beta/BMP signaling at the primary cilium.Cell Rep 2018;22(10):2584-92.
18 Mazo G,Soplop N,Wang WJ,Uryu K,Tsou MFB.Spatial control of primary ciliogenesis by subdistal appendages alters sensation-associated properties of cilia.Dev Cell 2016;39(4):424-37.
19 Mogensen MM,Malik A,Piel M,Bouckson-Castaing V,Bornens M.Microtubule minus-end anchorage at centrosomal and noncentrosomal sites:the role of ninein.J Cell Sci 2000;113(Pt 17):3013-23.
20 Guarguaglini G,Duncan PI,Stierhof YD,Holmstrom T,Duensing S,Nigg EA.The forkhead-associated domain protein Cep170 interacts with polo-like kinase 1 and serves as a marker for mature centrioles.Mol Biol Cell 2005;16(3):1095-107.
21 Gromley A,Jurczyk A,Sillibourne J,Halilovic E,Mogensen M,Groisman I,et al.A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase.J Cell Biol 2003;161(3):535-45.
22 Veleri S,Manjunath SH,Fariss RN,May-Simera H,Brooks M,Foskett TA,et al.Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.Nat Commun 2014;5:4207.
23 Chang P,Giddings TH,Winey M,Stearns T.epsilon-tubulin is required for centriole duplication and microtubule organization.Nat Cell Biol 2003;5(1):71-6.
24 Nishizawa M,Izawa I,Inoko A,Hayashi Y,Nagata K,Yokoyama T,et al.Identification of trichoplein,a novel keratin filamentbinding protein.J Cell Sci 2005;118(Pt 5):1081-90.
25 Gould R,Borisy G.The Pericentriolar material in Chinese hamster ovary cells nucleates microtubules formation.J Cell Biol1977;73(3):601-15.
26 Woodruff JB,Wueseke O,Hyman AA.Pericentriolar material structure and dynamics.Philos Trans R Soc Lond B Biol Sci2014;doi:10.1098/rstb.2013.0459.
27 Lawo S,Hasegan M,Gupta GD,Pelletier L.Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material.Nat Cell Biol 2012;14(11):1148-58.
28 Tsou MF,Wang WJ,George KA,Uryu K,Stearns T,Jallepalli PV.Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.Dev Cell 2009;17(3):344-54.
29 Uhlmann F,Wernic D,Poupart MA,Koonin EV,Nasmyth K.Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast.Cell 2000;103(3):375-86.
30 Schockel L,Mockel M,Mayer B,Boos D,Stemmann O.Cleavage of cohesin rings coordinates the separation of centrioles and chromatids.Nat Cell Biol 2011;13(8):966-72.
31 Tsou MF,Stearns T.Mechanism limiting centrosome duplication to once per cell cycle.Nature 2006;442(7105):947-51.
32 Mayor T,Stierhof YD,Tanaka K,Fry AM,Nigg EA.The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.J Cell Biol 2000;151(4):837-46.
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