益肾消痰通脉汤对高血压早期肾损伤患者尿微量白蛋白/肌酐比值及血清胱抑素C同型半胱氨酸的影响
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摘要
目的:探究益肾消痰通脉汤对高血压早期肾损伤患者尿mAlb/Cr比值及血清CysC、Hcy水平的影响。方法:选取本院收治的76例高血压早期肾损伤患者为研究对象,将患者按随机数字表法分为观察组和对照组,每组38例。对照组进行常规西医治疗,观察组在对照组基础上加用益肾消痰通脉汤治疗,3个月后统计疗效,并于治疗前后测定两组患者尿mAlb/C比值及血清CysC、Hcy水平,计录不良反应发生情况。结果:观察组患者临床总有效率为89. 5%,对照组患者总有效率为76. 3%,两组疗效比较差异具有统计学意义(P <0. 05);两组患者治疗后尿mAlb/Cr比值及血清CysC、Hcy水平较治疗前均显著下降,观察组患者治疗后三者均低于对照组,差异具有统计学意义(P <0. 05);两组患者治疗后不良反应发生率差异无统计学意义(P> 0. 05)。结论:益肾消痰通脉汤能够有效地治疗高血压早期肾损伤,降低患者尿mAlb/Cr比值及血清Cyst-C、Hcy水平,改善患者肾功能。
Objective: Discussing the effects of Yishen Xiaotan Tongmai Tang on urine mAlb/Cr and serum CysC and Hcy levels in hypertension patients with early renal injury. Methods: 76 Cases hypertension patients with early renal injury were selected and divided into observation and control groups according to random number table,each contained 38 cases. Control group was treated with routine Western medicine treatment,observation group was treated with Yishen Xiaotan Tongmai Tang on the basis of control group,curative effect was evaluated after treating for 3 months,urine mAlb/Cr and serum CysC and Hcy levels were determined before and after treatment,adverse reactions were recorded. Results: The total effective rate of observation group was 89. 5%,that was better than that of control group( 76. 3%),the difference between the two groups was statistical significance( P < 0. 05); the urine mAlb/Cr and serum CysC and Hcy levels in the two groups were lowered,the three indexes in observation group were significantly lower than those of control group( P < 0. 05); there was no statistical significance between the two groups in adverse reactions( P > 0. 05). Conclusion: Yishen Xiaotan Tongmai Tang can effectively treat hypertension patients with early renal injury,decreasing urine mAlb/Cr and serum CysC,Hcy levels,improving renal function.
Objective: Discussing the effects of Yishen Xiaotan Tongmai Tang on urine mAlb/Cr and serum CysC and Hcy levels in hypertension patients with early renal injury. Methods: 76 Cases hypertension patients with early renal injury were selected and divided into observation and control groups according to random number table,each contained 38 cases. Control group was treated with routine Western medicine treatment,observation group was treated with Yishen Xiaotan Tongmai Tang on the basis of control group,curative effect was evaluated after treating for 3 months,urine mAlb/Cr and serum CysC and Hcy levels were determined before and after treatment,adverse reactions were recorded. Results: The total effective rate of observation group was 89. 5%,that was better than that of control group( 76. 3%),the difference between the two groups was statistical significance( P < 0. 05); the urine mAlb/Cr and serum CysC and Hcy levels in the two groups were lowered,the three indexes in observation group were significantly lower than those of control group( P < 0. 05); there was no statistical significance between the two groups in adverse reactions( P > 0. 05). Conclusion: Yishen Xiaotan Tongmai Tang can effectively treat hypertension patients with early renal injury,decreasing urine mAlb/Cr and serum CysC,Hcy levels,improving renal function.
引文
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[11]汪江涛,丁伯平,柏松,等.钩藤碱对肾性高血压大鼠心肌中叶素及其受体表达的影响[J].中成药,2013,35(6):1129-1133.
[12]张勤,杨云梅,余国友.天麻素注射液对老年难治性高血压患者血压和血管活性物质影响的随机对照研究[J].中西医结合学报,2008,6(7):695-699.
[13]Singh R,Tandon I,Deo S,et al. Does microalbuminuria at mid-pregnancy predict development of subsequent preeclampsia?[J]. J Obstet Gynaecol Res,2013,39(2):478-483.
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[15]张清平,邹长进,张敏.高血压肾病患者血清NGAL与Cys-c水平探讨[J].中国卫生检验杂志,2013:23(9):2203-2204.
[16]张爱民,许莹.同型半胱氨酸在原发性高血压早期肾脏损伤中的诊断价值研究[J].临床合理用药杂志,2012,5(3):16.
[17]熊伟,司徒洁,王珉,等.血清胱抑素C和同型半胱氨酸在原发性高血压患者早期肾功能损害中的临床价值[J].中国医药科学,2016,6(9):204-206.
[2]包伟,黄晓佳,顾宁.高血压早期肾损害中西医研究进展[J].辽宁中医药大学学报,2018,20(3):166-169.
[3]中国高血压防治指南修订委员会.中国高血压防治指南[J].中华高血压杂志,2010,19(8):701-743.
[4]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:156.
[5]Pei XH,He J,Liu Q,et al. Evaluation of serum creatinine and cystatin C based equations for the estimation of glomerular filtration rate in a Chinese population[J]. Scand J Urol Nephrol,2012,46(3):223-231.
[6]任颖,王桂莲.联合检测血清胱抑素C、同型半胱氨酸和尿微量白蛋白对早期糖尿病肾病的诊断价值[J].中国中西医结合肾病杂志,2017,18(11):967-968.
[7]杨自更,郭勇,蔡冰冰,等. SPECT肾动态显像测定肾功能在原发性高血压早期肾损害中的应用价值[J].现代医药卫生,2009,25(19):2897-2898.
[8]关月.丹参-红花心脏保护及丹参-大黄肾脏保护的药效物质及作用机制研究[D].西安:第四军医大学,2015.
[9]姜凌宇,姜月华,郭金昊,等.杜仲治疗高血压研究进展[J].山东中医杂志,2017,36(3):249-252.
[10]徐婷,王微.川牛膝水煎液对自发性高血压大鼠血压和左心室肥厚的影响[J].长春中医药大学学报,2008,24(4):367.
[11]汪江涛,丁伯平,柏松,等.钩藤碱对肾性高血压大鼠心肌中叶素及其受体表达的影响[J].中成药,2013,35(6):1129-1133.
[12]张勤,杨云梅,余国友.天麻素注射液对老年难治性高血压患者血压和血管活性物质影响的随机对照研究[J].中西医结合学报,2008,6(7):695-699.
[13]Singh R,Tandon I,Deo S,et al. Does microalbuminuria at mid-pregnancy predict development of subsequent preeclampsia?[J]. J Obstet Gynaecol Res,2013,39(2):478-483.
[14]陈颖文.血清胱抑素与妊娠期高血压疾病预后的相关性研究[J].中华临床医师杂志:电子版,2014,8(20):3709-3711.
[15]张清平,邹长进,张敏.高血压肾病患者血清NGAL与Cys-c水平探讨[J].中国卫生检验杂志,2013:23(9):2203-2204.
[16]张爱民,许莹.同型半胱氨酸在原发性高血压早期肾脏损伤中的诊断价值研究[J].临床合理用药杂志,2012,5(3):16.
[17]熊伟,司徒洁,王珉,等.血清胱抑素C和同型半胱氨酸在原发性高血压患者早期肾功能损害中的临床价值[J].中国医药科学,2016,6(9):204-206.