中医药治疗卵巢巧克力囊肿作用机制研究
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摘要
卵巢巧克力囊肿是育龄期女性的常见妇科疾病,严重影响女性的生活质量。长期以来,中医药在缓解卵巢巧克力囊肿的不适症状和提高妊娠率的治疗过程中疗效显著,日益成为学术界关注的热点和焦点。现对中医药在卵巢巧克力囊肿治疗中的作用及其机制研究进行综述,期望为广大科研和临床工作者提供新的指导和启发,拓宽临证思路,提高卵巢巧克力囊肿的临床治疗疗效。
Ovarian chocolate cysts is a common gynecological disease in child-bearing period female and seriously affect women's quality of life. For a long time,traditional chinese medicine has been effective in relieving the symptoms of ovarian chocolate cysts and improving the pregnancy rate. It has increasingly become a hot point and focus in the academic community. This article summarizes the research on the effect and mechanism of traditional chinese medicine in the treatment of ovarian chocolate cysts. It is expected to provide new guidance and enlightenment for the majority of scientific research and clinicians,broaden the clinical thinking and improve the clinical curative effect of ovarian chocolate cysts.
Ovarian chocolate cysts is a common gynecological disease in child-bearing period female and seriously affect women's quality of life. For a long time,traditional chinese medicine has been effective in relieving the symptoms of ovarian chocolate cysts and improving the pregnancy rate. It has increasingly become a hot point and focus in the academic community. This article summarizes the research on the effect and mechanism of traditional chinese medicine in the treatment of ovarian chocolate cysts. It is expected to provide new guidance and enlightenment for the majority of scientific research and clinicians,broaden the clinical thinking and improve the clinical curative effect of ovarian chocolate cysts.
引文
[1]谢幸,苟文丽.妇产科学[M].北京:人民卫生出版社,2013:270.
[2]刘玉婷,史宏晖,于昕,等.卵巢子宫内膜异位囊肿合并感染32例临床分析[J].实用妇产科杂志,2017,33(1):39-42.
[3]Kim HS,Kim TH,Chung HH,et al. Risk and prognosis of o-varian cancer in women with endometriosis:a meta-analysis[J]. Br J Cancer,2014,110(7):1878-1890.
[4]王肖,尤昭玲.浅析尤昭玲教授对子宫内膜异位症的认识及中医治疗特色[J].中华中医药杂志,2014,29(8):2457.
[5]蔡宇萍,曹佃贵.陈颖异治疗子宫内膜异位症思路和方法[J].中华中医药杂志,2011,26(7):1552-1554.
[6]李晓丹,邵瑞萌,高俊华,等.易修珍扶正化瘀治疗子宫内膜异位性疾病[J].中华中医药杂志,2017,32(9):4032-4034.
[7]韩凤娟,盛霄燕,田苗,等.针刺疗法配合琥珀散加减治疗气滞血瘀型卵巢巧克力样囊肿30例[J].针灸临床杂志,2015,31(3):18-20.
[8]任洁宁.补肾化瘀汤联合米非司酮治疗卵巢子宫内膜异位症临床观察[J].四川中医,2017,35(12):170-173.
[9]杨红,齐聪,周华.益气活血方治疗卵巢子宫内膜异位囊肿术后复发118例[J].上海中医药杂志,2011,45(8):39-41.
[10]王娜娜,赵瑞华,夏文艳.活血消异方抑制盆腔子宫内膜异位症保守术后复发的病例研究[J].中华中医药杂志,2017,32(8):3861-3864.
[11]万凌屹,周凌娟,丁彩飞.血府逐瘀汤加减对卵巢子宫内膜异位囊肿术后卵巢功能及妊娠结局的影响[J].中华中医药学刊,2016,34(1):173-176.
[12]苏燕燕. GnRHa联合桂枝茯苓胶囊对卵巢巧克力囊肿腹腔镜剥除术后康复及卵巢功能和妊娠结局的影响[J].现代中西医结合杂志,2018,27(8):843-846.
[13]中国中西医结合学会妇产科专业委员会.子宫内膜异位症、妊娠高血压综合征及女性不孕症的中西医结合诊断标准[S].中国中西医结合杂志,1991,11(6):376-379.
[14]俞而慨,曹玲仙.中医药治疗子宫内膜异位症作用机制研究进展[J].上海中医药杂志,2010,44(2):76-80.
[15]梁雪芳,冉青珍,李燕钰.中药综合治疗对盆腔子宫内膜异位症患者盆腔状态的影响[J].时珍国医国药,2006,17(9):1767-1768.
[16]魏绍斌,杨心弦,郭蓉晓,等.内异康复栓直肠给药对子宫内膜异位症模型大鼠血液流变的影响[J].中华中医药学刊,2006,24(2):242-243.
[17]马小娜,刘丹彤,闫军堂,等.两种子宫内膜异位症大鼠模型的血液流变学及单胺类神经递质比较研究[J].中华中医药学刊,2012,30(1):179-181.
[18]张晓芳,张宜群.滋阴补阳中药对子宫内膜异位症合并不孕患者血清性激素水平与妊娠结局的影响研究[J].中国性科学,2016,25(4):129-132.
[19]孙阿梅,刘长云,刘汉蓉,等.补肾祛瘀方联合丹那唑对子宫内膜异位症患者血清雌/孕激素、前列腺素的影响[J].世界中医药,2018,13(3):683-686,690.
[20]Brenner RM,Nayak NR,Slayden OD,et al. Premenstrual and menstrual changes in the macaque and human endometrium:relevance to en-dometriosis[J]. Ann N Y Acad Sci,2002,955(1):60-74,86-88,396-406.
[21]付金荣,郑锦,胡晓梅,等.盆痛灵直肠给药治疗子宫内膜异位症盆腔痛的临床观察[J].上海中医药杂志,2007,41(3):35-36.
[22]路云晶,吴亚男.当归芍药散对子宫内膜异位症型痛经患者前列腺素及孕激素影响[J].辽宁中医药大学学报,2017,19(4):139-141.
[23]魏玲,王军,张宗敏.宣郁通经汤与血府逐瘀胶囊治疗子宫内膜异位症痛经疗效观察[J].四川中医,2017,35(12):173-175.
[24]Lee SW,Liong ML,Yuen KH,et al. Acupuncture and immune function in chronic prostatitis/chronic pelvic pain syndrome:a randomized,controlled study[J]. Complement Ther Med,2014,22(6):965-969.
[25]Peng L,Wang Y,Chang X,et al. Effect of moxa-burning heat stimulating Liangmen(ST 21)and Zusanli(ST 36)on prolifera-tion and apoptosis signaling proteins in rats with stress-in-duced gastric ulcer[J]. J Tradit Chin Med,2016,36(3):340-346.
[26]周悦芳,范培红.中药免疫调节作用研究进展[J].时珍国医国药,2017,28(1):204-207.
[27]杨红,齐聪,曾惠.益气活血方治疗复发性卵巢子宫内膜异位囊肿的疗效及对IL-2、IL-6的影响[J].中华中医药学刊,2017,35(2):460-462.
[28]李淑萍,刘晨,薛茜,等.针刺疗法对子宫内膜异位症模型鼠免疫功能的影响[J].辽宁中医杂志,2008,35(4):595-596.
[29]曹立幸,司徒仪,黄健玲,等.化瘀消症散结法防治卵巢子宫内膜异位囊肿术后复发对免疫功能的影响[J].辽宁中医杂志,2008,35(3):357-359.
[30]Cho SH,Oh YJ,Nam A,et al. Evaluation of serum andurinary angiogenic factors in patients with endometriosis[J]. Am J Reprod Immunol,2007,6(58):497-504.
[31]黄映红,徐晓娟,秦旭华,等.内异康复片对EMT大鼠VEGF、MMP-9、HGF及Wnt4、Wnt5α的调控机制研究[J].新中医,2016,48(9):217-221.
[32]杨红,陈静,叶妮,等.益气活血方对子宫内膜异位症大鼠在位及异位内膜NF-κB及“3A”能力的影响[J].四川中医,2017,35(4):58-61.
[33]周华,齐聪,杨红,等.补肾活血方对大鼠子宫内膜细胞病理形态学及凋亡的影响[J].上海中医药大学学报,2012,22(6):96-100.
[34]姜虹,贺丰杰,朱虹丽,等.宫瘤消胶囊对子宫内膜异位症大鼠异位内膜组织病理学的影响[J].现代中医药,2018,38(2):87-89,92.
[2]刘玉婷,史宏晖,于昕,等.卵巢子宫内膜异位囊肿合并感染32例临床分析[J].实用妇产科杂志,2017,33(1):39-42.
[3]Kim HS,Kim TH,Chung HH,et al. Risk and prognosis of o-varian cancer in women with endometriosis:a meta-analysis[J]. Br J Cancer,2014,110(7):1878-1890.
[4]王肖,尤昭玲.浅析尤昭玲教授对子宫内膜异位症的认识及中医治疗特色[J].中华中医药杂志,2014,29(8):2457.
[5]蔡宇萍,曹佃贵.陈颖异治疗子宫内膜异位症思路和方法[J].中华中医药杂志,2011,26(7):1552-1554.
[6]李晓丹,邵瑞萌,高俊华,等.易修珍扶正化瘀治疗子宫内膜异位性疾病[J].中华中医药杂志,2017,32(9):4032-4034.
[7]韩凤娟,盛霄燕,田苗,等.针刺疗法配合琥珀散加减治疗气滞血瘀型卵巢巧克力样囊肿30例[J].针灸临床杂志,2015,31(3):18-20.
[8]任洁宁.补肾化瘀汤联合米非司酮治疗卵巢子宫内膜异位症临床观察[J].四川中医,2017,35(12):170-173.
[9]杨红,齐聪,周华.益气活血方治疗卵巢子宫内膜异位囊肿术后复发118例[J].上海中医药杂志,2011,45(8):39-41.
[10]王娜娜,赵瑞华,夏文艳.活血消异方抑制盆腔子宫内膜异位症保守术后复发的病例研究[J].中华中医药杂志,2017,32(8):3861-3864.
[11]万凌屹,周凌娟,丁彩飞.血府逐瘀汤加减对卵巢子宫内膜异位囊肿术后卵巢功能及妊娠结局的影响[J].中华中医药学刊,2016,34(1):173-176.
[12]苏燕燕. GnRHa联合桂枝茯苓胶囊对卵巢巧克力囊肿腹腔镜剥除术后康复及卵巢功能和妊娠结局的影响[J].现代中西医结合杂志,2018,27(8):843-846.
[13]中国中西医结合学会妇产科专业委员会.子宫内膜异位症、妊娠高血压综合征及女性不孕症的中西医结合诊断标准[S].中国中西医结合杂志,1991,11(6):376-379.
[14]俞而慨,曹玲仙.中医药治疗子宫内膜异位症作用机制研究进展[J].上海中医药杂志,2010,44(2):76-80.
[15]梁雪芳,冉青珍,李燕钰.中药综合治疗对盆腔子宫内膜异位症患者盆腔状态的影响[J].时珍国医国药,2006,17(9):1767-1768.
[16]魏绍斌,杨心弦,郭蓉晓,等.内异康复栓直肠给药对子宫内膜异位症模型大鼠血液流变的影响[J].中华中医药学刊,2006,24(2):242-243.
[17]马小娜,刘丹彤,闫军堂,等.两种子宫内膜异位症大鼠模型的血液流变学及单胺类神经递质比较研究[J].中华中医药学刊,2012,30(1):179-181.
[18]张晓芳,张宜群.滋阴补阳中药对子宫内膜异位症合并不孕患者血清性激素水平与妊娠结局的影响研究[J].中国性科学,2016,25(4):129-132.
[19]孙阿梅,刘长云,刘汉蓉,等.补肾祛瘀方联合丹那唑对子宫内膜异位症患者血清雌/孕激素、前列腺素的影响[J].世界中医药,2018,13(3):683-686,690.
[20]Brenner RM,Nayak NR,Slayden OD,et al. Premenstrual and menstrual changes in the macaque and human endometrium:relevance to en-dometriosis[J]. Ann N Y Acad Sci,2002,955(1):60-74,86-88,396-406.
[21]付金荣,郑锦,胡晓梅,等.盆痛灵直肠给药治疗子宫内膜异位症盆腔痛的临床观察[J].上海中医药杂志,2007,41(3):35-36.
[22]路云晶,吴亚男.当归芍药散对子宫内膜异位症型痛经患者前列腺素及孕激素影响[J].辽宁中医药大学学报,2017,19(4):139-141.
[23]魏玲,王军,张宗敏.宣郁通经汤与血府逐瘀胶囊治疗子宫内膜异位症痛经疗效观察[J].四川中医,2017,35(12):173-175.
[24]Lee SW,Liong ML,Yuen KH,et al. Acupuncture and immune function in chronic prostatitis/chronic pelvic pain syndrome:a randomized,controlled study[J]. Complement Ther Med,2014,22(6):965-969.
[25]Peng L,Wang Y,Chang X,et al. Effect of moxa-burning heat stimulating Liangmen(ST 21)and Zusanli(ST 36)on prolifera-tion and apoptosis signaling proteins in rats with stress-in-duced gastric ulcer[J]. J Tradit Chin Med,2016,36(3):340-346.
[26]周悦芳,范培红.中药免疫调节作用研究进展[J].时珍国医国药,2017,28(1):204-207.
[27]杨红,齐聪,曾惠.益气活血方治疗复发性卵巢子宫内膜异位囊肿的疗效及对IL-2、IL-6的影响[J].中华中医药学刊,2017,35(2):460-462.
[28]李淑萍,刘晨,薛茜,等.针刺疗法对子宫内膜异位症模型鼠免疫功能的影响[J].辽宁中医杂志,2008,35(4):595-596.
[29]曹立幸,司徒仪,黄健玲,等.化瘀消症散结法防治卵巢子宫内膜异位囊肿术后复发对免疫功能的影响[J].辽宁中医杂志,2008,35(3):357-359.
[30]Cho SH,Oh YJ,Nam A,et al. Evaluation of serum andurinary angiogenic factors in patients with endometriosis[J]. Am J Reprod Immunol,2007,6(58):497-504.
[31]黄映红,徐晓娟,秦旭华,等.内异康复片对EMT大鼠VEGF、MMP-9、HGF及Wnt4、Wnt5α的调控机制研究[J].新中医,2016,48(9):217-221.
[32]杨红,陈静,叶妮,等.益气活血方对子宫内膜异位症大鼠在位及异位内膜NF-κB及“3A”能力的影响[J].四川中医,2017,35(4):58-61.
[33]周华,齐聪,杨红,等.补肾活血方对大鼠子宫内膜细胞病理形态学及凋亡的影响[J].上海中医药大学学报,2012,22(6):96-100.
[34]姜虹,贺丰杰,朱虹丽,等.宫瘤消胶囊对子宫内膜异位症大鼠异位内膜组织病理学的影响[J].现代中医药,2018,38(2):87-89,92.