女性患者泌尿生殖道支原体感染状况和耐药性分析
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摘要
目的了解本地区女性泌尿生殖道支原体感染的流行特征及对常用抗菌药物的耐药性,为临床合理用药提供依据。方法回顾性分析2014年-2017年本院就诊疑似泌尿生殖道支原体感染女性患者的临床资料。结果 3 769例疑似泌尿生殖道支原体感染患者,1 622例(43.0%)支原体培养阳性,Uu单独感染率最高(33.8%),本地区女性支原体感染率呈逐年上升趋势(P<0.01),不同季节间夏季感染率最高(57.6%),感染人群主要集中在21岁～39岁(52.0%),不同职业间服务业从业者感染率最高(56.2%),不同文化程度间小学及以下患者感染率最高(63.9%)。药敏试验结果表明,3种支原体感染类型对交沙霉素、多西环素和美满霉素的耐药率均<10.0%。结论支原体感染与季节、年龄、文化程度、职业等有关,本地区女性支原体感染率呈逐年上升趋势,并以Uu单独感染为主,交沙霉素、多西环素、美满霉素可作为本地区治疗支原体感染的首选药物。
Objective To understand the epidemiological characteristics of urogenital mycoplasma infection and the resistance to common antibiotics among female patients in the region to provide a basis for clinical rational drug use. Methods The clinical data of female patients with suspected genitourinary tract infections in our hospital from 2014 to 2017 were retrospectively analyzed. Results 3 769 patients were suspected genitourinary tract infection, 1 622(43.0%) were positive for mycoplasma culture, and Uu had the highest infection rate(33.8%). The infection rate of female mycoplasma in the region increased year by year(P<0.01), and the summer infection rate was the highest(57.6%) in different seasons. The infected population was mainly concentrated in 21 to 39 years old(52.0%). The infection rate of service practitioners in different occupations was the highest(56.2%), and the infection rate of primary school and below was the highest(63.9%) among different educational levels. The results of drug susceptibility test showed that the resistance rates of three mycoplasma infection types to josamycin, doxycycline and minocycline were all <10.0%. Conclusion Mycoplasma infection was related to season, age, education level, occupation and so on, the infection rate of Mycoplasma in the area was increasing year by year, and Uu single infection was the main infection. Josamycin, doxycycline and minocycline can be used as the drug of choice for the treatment of mycoplasma infection in the region.
Objective To understand the epidemiological characteristics of urogenital mycoplasma infection and the resistance to common antibiotics among female patients in the region to provide a basis for clinical rational drug use. Methods The clinical data of female patients with suspected genitourinary tract infections in our hospital from 2014 to 2017 were retrospectively analyzed. Results 3 769 patients were suspected genitourinary tract infection, 1 622(43.0%) were positive for mycoplasma culture, and Uu had the highest infection rate(33.8%). The infection rate of female mycoplasma in the region increased year by year(P<0.01), and the summer infection rate was the highest(57.6%) in different seasons. The infected population was mainly concentrated in 21 to 39 years old(52.0%). The infection rate of service practitioners in different occupations was the highest(56.2%), and the infection rate of primary school and below was the highest(63.9%) among different educational levels. The results of drug susceptibility test showed that the resistance rates of three mycoplasma infection types to josamycin, doxycycline and minocycline were all <10.0%. Conclusion Mycoplasma infection was related to season, age, education level, occupation and so on, the infection rate of Mycoplasma in the area was increasing year by year, and Uu single infection was the main infection. Josamycin, doxycycline and minocycline can be used as the drug of choice for the treatment of mycoplasma infection in the region.
引文
[1] 陈丽婷,陈垂婉.2011～2013年支原体感染流行特征及耐药性分析[J].国际检验医学杂志,2015,36(10):1402-1406.
[2] 郭燕峰,董虹.4 694例宫颈分泌物Uu、Mh检出率及药敏探析[J].中国妇幼健康研究,2014,25(1):113-115.
[3] 肖淑珍,韩立中,王文奎.279株泌尿生殖道分离解脲脲原体的药敏分析[J].上海交通大学学报:医学版,2016,36(4):546-549.
[4] 邱悦,付玉荣,伊正君.山东省日照市2012年至2014年非淋球菌性尿道炎支原体感染及耐药分析[J].中华传染病杂志,2016,34(1):41-43.
[5] 徐峰.2013至2015年泌尿生殖道支原体感染的耐药性变迁[J].检验医学,2016,31(7):630-631.
[6] 王莉,江志红,徐静,等.1438例泌尿生殖道支原体感染情况及耐药分析[J].检验医学与临床,2016,13(10):1382-1384.
[7] 贾双荣,胡萌,蒋琳华,等.重庆地区4414例泌尿生殖道支原体检测及药敏分析[J].重庆医学,2017,46(5):609-611.
[8] 孙红岗,何丽钦,朱莹.2013-2015年绍兴地区非淋菌性尿道炎支原体感染及药敏结果分析[J].国际流行病学传染病学杂志,2017,44(2):141-142.
[9] 杨崇勤,郭小乐.731份女性泌尿生殖道支原体感染及药敏状况分析[J].现代预防医学杂志,2017,44(5):812-814.
[10] 毛丽芬.女性泌尿生殖道支原体感染的调查与耐药性分析[J].中国卫生检验杂志,2016,26(17):2561-2563.
[11] 倪小平,雷丽红,戴凌红,等.温州市城区已婚妇女生殖道解脲脲支原体感染的致病危险因素分析[J].中华医院感染学杂志,2013,23(5):1076-1156.
[12] 汪洪,巴玲丽,舒南北,等.8 297例可疑泌尿生殖道疾病患者支原体感染状况及1 012例药敏分析[J].安徽医药,2014,18(12):2317-2319.
[13] 尧荣凤,李智,沈菊英,等.泌尿生殖道支原体药物敏感性试验结果动态分析[J].检验医学,2016,31(12):1050-1054.
[14] Gunyeli I,Abike F,Dunder I,et al.Chlamydia,Mycoplasma and Ureaplasma infections in infertile couples and effects of these in-fections on fertility[J].Arch Gynecolobstet,2011,283(2):379-385.
[15] 陈吉林,石玲,谢华,等.泌尿系统解脲脲原体感染耐药性分析[J].中国感染控制杂志,2015,34(6):820-822.
[2] 郭燕峰,董虹.4 694例宫颈分泌物Uu、Mh检出率及药敏探析[J].中国妇幼健康研究,2014,25(1):113-115.
[3] 肖淑珍,韩立中,王文奎.279株泌尿生殖道分离解脲脲原体的药敏分析[J].上海交通大学学报:医学版,2016,36(4):546-549.
[4] 邱悦,付玉荣,伊正君.山东省日照市2012年至2014年非淋球菌性尿道炎支原体感染及耐药分析[J].中华传染病杂志,2016,34(1):41-43.
[5] 徐峰.2013至2015年泌尿生殖道支原体感染的耐药性变迁[J].检验医学,2016,31(7):630-631.
[6] 王莉,江志红,徐静,等.1438例泌尿生殖道支原体感染情况及耐药分析[J].检验医学与临床,2016,13(10):1382-1384.
[7] 贾双荣,胡萌,蒋琳华,等.重庆地区4414例泌尿生殖道支原体检测及药敏分析[J].重庆医学,2017,46(5):609-611.
[8] 孙红岗,何丽钦,朱莹.2013-2015年绍兴地区非淋菌性尿道炎支原体感染及药敏结果分析[J].国际流行病学传染病学杂志,2017,44(2):141-142.
[9] 杨崇勤,郭小乐.731份女性泌尿生殖道支原体感染及药敏状况分析[J].现代预防医学杂志,2017,44(5):812-814.
[10] 毛丽芬.女性泌尿生殖道支原体感染的调查与耐药性分析[J].中国卫生检验杂志,2016,26(17):2561-2563.
[11] 倪小平,雷丽红,戴凌红,等.温州市城区已婚妇女生殖道解脲脲支原体感染的致病危险因素分析[J].中华医院感染学杂志,2013,23(5):1076-1156.
[12] 汪洪,巴玲丽,舒南北,等.8 297例可疑泌尿生殖道疾病患者支原体感染状况及1 012例药敏分析[J].安徽医药,2014,18(12):2317-2319.
[13] 尧荣凤,李智,沈菊英,等.泌尿生殖道支原体药物敏感性试验结果动态分析[J].检验医学,2016,31(12):1050-1054.
[14] Gunyeli I,Abike F,Dunder I,et al.Chlamydia,Mycoplasma and Ureaplasma infections in infertile couples and effects of these in-fections on fertility[J].Arch Gynecolobstet,2011,283(2):379-385.
[15] 陈吉林,石玲,谢华,等.泌尿系统解脲脲原体感染耐药性分析[J].中国感染控制杂志,2015,34(6):820-822.